(S)-3-Methylamino-1-(thiophene-2-yl)Propan-1-ol

(S) -3-methylamino-1- (thiophene-2-yl) propane-1-ol, whose molecules are composed of carbon, hydrogen, nitrogen, oxygen, sulfur and other elements. Looking at its name, " (S) " indicates that it has a specific chiral configuration, which is a key feature of spatial arrangement. "3-methylamino", indicating that it is connected to the amino group at the third position of the main chain of propanol. The amino group is a nitrogen-containing functional group, which is basic and can participate in many chemical reactions. " 1 - (thiophene-2 -yl) ", showing that the thiophene ring is connected to the first position of the main chain of propanol. Thiophene is a sulfur-containing five-membered heterocycle with aromatic properties, giving the compound unique chemical activity. The main chain of propanol contains three carbon atoms, and the hydroxyl group is connected to the first place, which is a characteristic functional group of alcohols, which can undergo substitution, oxidation and other reactions.
Its overall chemical structure is based on the propanol chain, and the side chain is modified with methylamino and thiophene groups. Each group affects each other to determine the physical and chemical properties of the compound. This structure may have unique application value in the fields of organic synthesis and medicinal chemistry, due to its chiral, amino, thiophene ring, alcohol hydroxyl and other structural characteristics, or it can be used as a key intermediate for the synthesis of complex biologically active molecules, or it has specific biological activity in itself, acting on specific targets to demonstrate pharmacological efficacy.

(S) - 3 -methylamino-1 - (thiophene-2-yl) propane-1 - alcohol This substance has various physical properties. Under normal conditions, it is a colorless to light yellow oily liquid, and its quality can be seen from the perspective of uniform and clear.
Smell, it has a weak and specific smell, not pungent and intolerable, but also has its unique smell. The cause of this smell is related to the existence of thiophene groups and amino and hydroxyl groups in the molecular structure.
As for the melting boiling point, its melting point is very low, and it cannot solidify at room temperature, while the boiling point is relatively high, about [specific boiling point value] ℃. Due to the existence of hydrogen bonds and van der Waals forces between molecules, the molecules are relatively tightly bound, and high energy is required to make them boil.
In terms of solubility, this substance has a certain solubility in water and common organic solvents such as ethanol and ether. In water, due to the hydrophilicity of hydroxyl groups, it can form hydrogen bonds with water molecules, so it can be dissolved to a certain extent. In organic solvents, the presence of thiophenyl groups and methyl groups and other non-polar parts makes it soluble with non-polar organic solvents. This property is crucial in many chemical processes and applications. < Br >
The density is slightly smaller than that of water, about [specific density value] g/cm ³. When placed in water, it can float on the water surface. This density characteristic is of great significance in separation and mixing operations. In addition, its refractive index also has a specific value, which is [specific refractive index value]. This parameter can be used as an important indicator in optical correlation research and quality identification.

(S) -3 -methylamino-1 - (thiophene-2-yl) propane-1-ol, which is an important intermediate in organic synthesis and has a wide range of uses in the field of medicinal chemistry.
In the process of the creation of Guanfu Pharmaceutical, this compound is often used as a key starting material. Due to its unique molecular structure, it contains thiophene ring, alcoholic hydroxyl group and amino group, and these structures endow it with diverse reactivity. With various techniques of organic synthesis, its functional groups can be skillfully modified to construct compounds with complex structures and specific biological activities.
In many drug development examples, based on it, through multi-step reaction, drug molecules can be synthesized to target specific disease-related targets. For example, in the field of neurological disease drug research, using this as a starting material, through delicate chemical transformation, compounds with regulatory effects on neurotransmitter receptors can be obtained, which is expected to provide novel strategies for the treatment of epilepsy, Parkinson's disease and other diseases.
Furthermore, in the development of antibacterial drugs, it can also be seen. By modifying and modifying its structure, the synthesized new compounds may exhibit unique antibacterial mechanisms to deal with the increasingly serious problem of drug-resistant bacteria.
In summary, (S) -3-methylamino-1- (thiophene-2-yl) propyl-1-ol, with its special structure, provides a key opportunity and material basis for the creation of new drugs and the solution of various diseases in the process of pharmaceutical research and development.

To prepare (S) -3-methylamino-1- (thiophene-2-yl) propane-1-ol, there are many methods, and the following are common preparation methods.
First, a suitable enol derivative can be started. First, an enol with a specific substitution is taken, and a halogenation reaction is carried out to introduce a halogen atom. This halogen atom is active and easy to attack by a nucleophilic reagent. Subsequently, a nucleophilic substitution reaction is carried out with methylamine as a nucleophilic reagent to replace the halogen atom with a methylamino group. Then, the double bond of the obtained product is hydrogenated and reduced, and other reducible groups in the molecule are properly protected and de-protected, and the final target product can be obtained. Although this approach is complex, the reaction conditions of each step are relatively mild, and the yield is relatively considerable.
Second, thiophene-2-formaldehyde can also be used as a raw material. Schilling thiophene-2-formaldehyde and diethyl malonate undergo a condensation reaction under basic conditions to generate the corresponding unsaturated ester. The unsaturated ester is then selectively reduced to reduce the carbon-carbon double bond, while the ester group is retained. After that, the ester group is hydrolyzed into a carboxyl group, which is then converted into an acid chloride by reacting with sulfoxide chloride. The acid chloride reacts with methylamine to form an amide. Finally, the amide is reduced to an alcohol by using a strong reducing agent such as lithium aluminum hydride to obtain (S) -3-methylamino-1 - (thiophene-2-yl) propane-1-ol. The raw materials for this method are easy to obtain, but some reactions require strict anhydrous and anaerobic conditions, which requires quite high operation.
Third, the chiral source can also be started. The compound with a suitable chiral center is selected, and the target molecular structure is gradually constructed through a series of functional group transformations. For example, selecting a chiral alcohol, introducing thiophene-2-yl through the conversion of hydroxyl groups, and then introducing methylamino through the amination reaction to obtain the target product. This approach can effectively control the stereochemistry of the product, but the selection and acquisition of chiral sources may be difficult.
All production methods have advantages and disadvantages. The actual synthesis needs to be carefully selected according to factors such as raw material availability, reaction conditions, cost, and requirements for product purity and optical purity.

(S) - 3-Methylamino-1 - (thiophene-2-yl) propane-1-ol. When using this substance, there are many things to pay attention to and need to be cautious.
The first thing to bear the brunt is the issue of safety protection. This substance may be toxic and irritating, so when using it, you must wear suitable protective equipment, such as gloves, goggles, protective clothing, etc., to prevent it from coming into contact with the skin and eyes, and to avoid inhaling its dust and steam. If you come into contact accidentally, rinse with plenty of water immediately, and seek medical treatment quickly according to the specific situation.
Furthermore, the method of storage should not be underestimated. It needs to be stored in a cool, dry and well-ventilated place, away from fire and heat sources, to prevent its properties from changing due to environmental factors such as temperature and humidity, or even cause danger. And it should be stored separately from oxidants and acids to avoid mutual reactions and endanger safety.
The operation process also needs to be rigorous. Before use, be sure to clarify its physical and chemical properties and strictly follow the established operating procedures. Weighing, transfer and other steps need to be accurate, and the temperature and humidity of the experimental environment and ventilation conditions should be properly regulated to ensure the accuracy of experimental results and the safety of operation.
In addition, waste disposal should not be sloppy. After use, the remaining substances and related waste must not be discarded at will, and must be treated harmlessly in accordance with relevant regulations to prevent pollution to the environment.
In short, when using (S) -3-methylamino-1- (thiophene-2-yl) propyl-1-ol, all the details are related to safety and effectiveness, and we must pay full attention and be careful.