N-tert-butylthiophene-2-sulfonamide

N-tert-butylthiophene-2-sulfonamide is an organic compound with interesting chemical properties. In this compound, the sulfonamide group is connected to the tert-butyl and thiophene rings, and the structure is unique, giving it specific chemical properties.
From the perspective of acidity and alkalinity, the sulfonamide group is weakly acidic. Because the nitrogen atom is connected to the sulfonyl group, the electron cloud is biased towards the sulfonyl group, so that the hydrogen atom on nitrogen is easier to dissociate and exhibits weak acidity.
On the discussion of nucleophilic and electrophilic reactivity, the thiophene ring is rich in electrons and prone to electrophilic substitution. The electron cloud density on the thiophene ring is high, which is attractive The electrophilic reagents tend to attack a specific position of the thiophene ring, and the reactivity is related to the localization effect of the substituent.
The sulfonamide part of N-tert-butyl thiophene-2-sulfonamide, the nitrogen atom has a lone pair electron, which can be used as a nucleophilic reagent to participate in the nucleophilic reaction. When it reacts with the electrophilic reagent, the lone pair electron attacks the electrophilic center and builds a new chemical bond.
In terms of thermal stability, tert-butyl is a large volume group, which has a certain stabilizing effect on the molecular structure. Under normal circumstances, this compound has a certain thermal stability, and can maintain structural stability in a moderate temperature range. In case of high temperature, or decomposition
In terms of solubility, there is a difference in solubility between polar and non-polar solvents due to the presence of polar sulfonamide groups and non-polar tert-butyl and thiophene rings. Generally, it has a certain solubility in polar organic solvents such as ethanol and acetone, but poor solubility in non-polar solvents such as n-hexane.
In addition, the compound may have certain biological activity. Sulfonamide compounds are often biologically active in the fields of medicine and pesticides, and N-tert-butyl thiophene-2-sulfonamide or interact with biological targets due to its unique structure, showing biological activities such as antibacterial and anti-inflammatory.

To prepare N-tert-butylthiophene-2-sulfonamide, various procedures are often followed. First, thiophene-2-sulfonyl chloride and tert-butylamine are used as materials. In a reaction kettle at a suitable temperature, first inject an appropriate amount of organic solvents, such as dichloromethane and tetrahydrofuran, to help the materials dissolve and promote the smooth reaction. After adding thiophene-2-sulfonyl chloride, tert-butylamine is slowly added, and acid binding agents, such as triethylamine and pyridine, are used to remove the acid generated by the reaction and prevent it from disturbing the reaction. During the reaction, it is necessary to control the temperature. It is usually done in an ice-water bath or an oil bath to stabilize the temperature within a certain range, generally about 0-30 ° C. After several times of reaction, the process is checked by thin-layer chromatography (TLC) or high-performance liquid chromatography (HPLC). After the raw materials are exhausted, the reaction is stopped. After extraction, washing, drying, column chromatography and other post-treatment processes, a pure product can be obtained.
Second, thiophene-2-sulfonic acid and tert-butylamine are used as the starting materials, and thiophene-2-sulfonic acid is first converted into its active ester, such as oxalyl chloride, dichlorosulfoxide, etc., to form the corresponding acid chloride. This step needs to be in an anhydrous environment, and the temperature is properly controlled to prevent side reactions. After obtaining acid chloride, react with tert-butylamine in an organic solvent according to the previous method, and purify it through a post-treatment process.
Or with other sulfur sources and amine sources, prepared by multi-step reaction. However, the above two methods, the raw materials are easy to obtain and the operation is relatively simple. They are commonly used in laboratory and industrial preparation, and each has its own suitability. According to the actual situation, such as raw material cost, product purity requirements, etc., choose and use them well.

N-tert-butylthiophene-2-sulfonamide is one of the organic compounds and is useful in many fields.
In the field of medicine, this compound is often a key intermediate in drug research and development. Because of its unique chemical structure, it can participate in the construction of drug molecules and help create new drugs with specific biological activities. Taking some antibacterial drugs as an example, by introducing N-tert-butylthiophene-2-sulfonamide structural fragments, it can optimize the affinity and selectivity of the drug to specific bacterial targets, enhance the antibacterial efficacy, and reduce the adverse effects on human normal cells.
In the field of materials science, it also has extraordinary performance. In the preparation of functional polymer materials, it can participate in the polymerization reaction as a functional monomer. Through this, polymer materials are endowed with special electrical, optical or thermal properties. For example, the synthesis of polymer materials with specific electrical conductivity or fluorescence properties is expected to be applied to organic Light Emitting Diode (OLED), sensors and other devices to improve the functionality and practicality of materials.
Furthermore, in the field of agricultural chemistry, N-tert-butylthiophene-2-sulfonamide may be used as an important raw material for the creation of pesticides. After rational structural modification and optimization, new pesticides with high efficiency, low toxicity and environmental friendliness have been created. Such pesticides may have highly selective inhibitory or killing effects on specific crop pests and pathogens, ensuring crop growth, improving agricultural production efficiency, and reducing pressure on the ecological environment.
In summary, N-tert-butylthiophene-2-sulfonamide has shown important application value in the fields of medicine, materials science and agricultural chemistry, providing strong support for technological innovation and development in various fields.

I look at the "N-tert-butylthiophene-2-sulfonamide" you are asking about. This is an organic compound, and its market price often varies depending on many factors.
The first to bear the brunt is the purity of the product. If the purity is very high, it reaches the scientific research level, and it is suitable for high-end experiments and precise synthesis, its price will be high. Because the purification process requires exquisite methods, expensive tools and exquisite skills, and costs a lot, the price will also rise. However, if it is only an ordinary purity commonly used in industry to meet general production needs, the price will be relatively easy.
Furthermore, the market supply and demand trend also affects its price. If at a certain time, in a certain field, many industries have a surge in demand for it, and the supply is limited, just like less water and more boats, the price will rise; on the contrary, if there is little demand and abundant supply, just like less boats and more water, the price will inevitably fall.
Origin and source are also key. Produced from a place with mature technology and exquisite cost control, or through an efficient supply chain, the price may be advantageous. For those who are shipped far away, or have scarce sources, the price will be affected due to the cost of transportation and difficulty in obtaining.
There is market competition. If there are many congeneric products in the market, the merchants may compete for a share, or they will compete on the price, so that the price stabilizes or decreases; if this product is an exclusive production and there are few competing products, the producer can price it according to the situation.
However, it is difficult for me to determine its specific price. To know the exact market price of this product, you can consult chemical product suppliers, trading platforms, or check relevant industry reports and market survey data to get an accurate number.

N-tert-butylthiophene-2-sulfonamide is one of the organic compounds. Its storage conditions are of paramount importance, and it is related to the quality and stability of this substance.
Cover this substance should be placed in a cool and dry place. A cool place can avoid the disturbance of high temperature. High temperature can accelerate its chemical reaction, or cause the risk of decomposition and deterioration. For example, during summer, if exposed to hot sun or a high temperature chamber, its molecular structure may be damaged and lose its inherent nature.
A dry environment is also indispensable. Water vapor in the air is easy to interact with the compound. If the moisture is too heavy, it may cause reactions such as hydrolysis. If you are in a humid place for a long time, the metal is easy to rust, and this compound is also easy to change due to moisture.
Furthermore, the storage must be well ventilated. Good ventilation can remove volatile gases that may accumulate. If the gas accumulates, one may cause the concentration to be too high, and there is a risk of explosion; the other may react with the compound for a second time, which will damage its quality.
and must be kept away from fire and heat sources. Fire and heat sources are both dangerous factors, which can make the compound react violently in an instant and endanger safety.
should also be stored separately from oxidizing agents, acids, bases and other substances. These kinds of substances have high chemical activity and coexist with N-tert-butylthiophene-2-sulfonamide, which can easily trigger chemical reactions and lead to unpredictable consequences.
In short, in order to properly store N-tert-butylthiophene-2-sulfonamide, the above conditions must be followed to ensure its stable properties and safe use.