N-tert-Butyl-2-thiophenesulfonamide

N-tert-butyl-2-thiophenesulfonamide has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to its unique structure, it can participate in a variety of chemical reactions, assisting chemists in constructing complex organic molecular structures.
In the field of pharmaceutical research and development, its importance cannot be underestimated. Or it can be modified to become a compound with specific biological activities, contributing to the creation of new drugs. For example, in the synthesis path of drugs for the treatment of certain diseases, it may act as a starting material or a key reaction intermediate to help synthesize drug molecules with targeted therapeutic effects.
In the field of materials science, it can also play a role. For example, in the preparation of some functional materials, it may participate in the reaction, endowing the material with unique physical and chemical properties, such as improving material stability, conductivity and other properties, and then expanding the application range of materials.
In the field of pesticide chemistry, N-tert-butyl-2-thiophenesulfonamide is also useful. Through rational design and reaction, high-efficiency, low-toxicity and environmentally friendly pesticide products can be prepared, providing strong support for agricultural pest control.

N-tert-butyl-2-thiophenesulfonamide is an organic compound, and its physical properties are worth exploring.
The appearance of this compound is often white to quasi-white solid, and it is quite stable at room temperature and pressure. Looking at its color and morphology, this white to quasi-white solid is one of the remarkable characteristics of this substance, which is convenient for preliminary identification in practical application and research.
When it comes to melting point, N-tert-butyl-2-thiophenesulfonamide has a specific melting point value. Melting point is an important physical property of a substance. By measuring the melting point, its purity can be identified. The presence of impurities often causes the melting point range to change or the melting point to decrease. Accurately knowing the melting point is crucial in experimental operations such as purification and identification of the substance.
Furthermore, solubility is also its key physical property. This compound exhibits different solubility characteristics in specific organic solvents. In some organic solvents such as dichloromethane and chloroform, it may have good solubility, but in water, it may have poor solubility. Such a difference in solubility is of great significance in the separation and purification steps of organic synthesis. It can be achieved by selecting a suitable solvent to achieve effective separation and purification of the target product.
Its density is also an inherent physical property. The determination of density helps to accurately calculate the relationship between substance dosage and volume in chemical production and experimental operations, ensuring that the reaction proceeds as expected, and avoiding unsatisfactory experimental or production results due to dosage deviations.
In addition, the stability of N-tert-butyl-2-thiophene sulfonamide is also an important consideration in many scenarios. Under normal conditions, the stability is good, and extreme conditions such as high temperature, strong acid and alkali may occur, or chemical reactions may occur, resulting in structural changes. Therefore, when storing and using, it is necessary to choose the appropriate environment and conditions according to its stability characteristics to prevent its deterioration from affecting the use effect.

The chemical properties of N-tert-butyl-2-thiophene sulfonamide are quite stable at room temperature. This compound has a unique molecular structure, which is cleverly connected by tert-butyl, thiophene ring and sulfonamide group.
Looking at its structure, tert-butyl is a group with steric hindrance, which exists in the molecule and can cause steric hindrance effect. This effect can affect the interaction between molecules in many chemical reactions, causing changes in reaction activity and selectivity. As a sulfur-containing five-membered heterocycle, thiophene ring is rich in electrons and exhibits aromaticity, which makes it have specific activity and regioselectivity in electrophilic substitution reactions. The sulfonamide group has a certain polarity and can participate in the formation of hydrogen bonds, which also has an important impact on the physical and chemical properties of the compound.
Under normal conditions, N-tert-butyl-2-thiophene sulfonamide can maintain stability to common weak acids and bases and mild oxidative reducing agents. However, when encountering strong acids and bases, the sulfonamide bond may be destroyed. It can also initiate reactions at high temperatures or in the presence of specific catalysts, such as substitution reactions on thiophene rings, or removal reactions of tert-butyl groups.
Overall, although the chemical properties of N-tert-butyl-2-thiophenesulfonamide are relatively stable, under specific conditions, the structure of each part of the molecule can exhibit different reactivity, resulting in a variety of chemical reactions.

The synthesis of N-tert-butyl-2-thiophenesulfonamide is an important topic in the field of organic synthesis. There are many methods, each with its own advantages and disadvantages, and should be selected according to the actual situation.
One is the method of using 2-thiophenesulfonyl chloride and tert-butylamine as raw materials. First take 2-thiophenesulfonyl chloride and dissolve it in suitable organic solvents, such as dichloromethane and chloroform. At low temperature and stirring state, tert-butylamine is slowly dripped. Among them, the control of low temperature is very important, and side reactions are caused by reaction or heat generation. After dripping, gradually raise to room temperature, and continue to stir for a while to make the reaction complete. After the reaction is completed, wash it with sodium bicarbonate solution, water, etc., and remove impurities. Then purified by distillation, column chromatography, etc., pure N-tert-butyl-2-thiophene sulfonamide can be obtained. The raw materials are easy to obtain, and the operation is not complicated. However, the reaction conditions need to be strictly controlled, and the by-products or purification is difficult.
The second is formed by the condensation reaction of 2-thiophene sulfonic acid and tert-butylamine. 2-thiophene sulfonic acid is first mixed with a condensing agent, such as dicyclohexyl carbodiimide (DCC), to activate the carboxyl group. After adding tert-butylamine, it is reacted with the solvent at an appropriate temperature. The choice and dosage of the condens After the reaction, the urea by-products generated by the condensation reaction are filtered out, and then the products are refined by extraction and recrystallization. This method can avoid the inconvenience of sulfonyl chloride, but the price of the condensation agent may be high, and the post-treatment also needs to be fine.
The third is to use thiophene as the starting material, which is obtained by sulfonation and amination. Thiophene is first treated with a sulfonating agent, such as concentrated sulfuric acid and fuming sulfuric acid, to obtain 2-thiophene sulfonic acid. Then 2-thiophene sulfonic acid is converted into sulfonyl chloride, which is then reacted with tert-butylamine. There are a little more steps in this path, but the starting material is cheap. However, the selectivity of the sulfonation reaction is poor, and isomers are prone to form, which affects the purity and yield of the product, so each step of the reaction needs to be fine-tuned and optimized.

Today there are N - tert - Butyl - 2 - thiophenesulfonamide this product, the price range in the market is difficult to determine. The price often varies due to many reasons, such as the source of materials, the supply and demand situation, the simplicity of the manufacturing process, or the competitive situation of the market.
Looking at the past chemical market, similar fine chemicals, if the material is easy to produce, the preparation method is still simple, and the market supply is oversupplied, the price may be slightly cheaper, the price per gram may be between a few yuan and several dozen yuan. On the contrary, if the material is rare, the preparation requires complicated processes, and the market is seeking a lot, the price must be high, the price per gram may reach more than 100 yuan, or even higher.
However, N - tert - Butyl - 2 - thiophenesulfonamide has not been able to study the source of materials, the difficulty of production, and the details of supply and demand in the market, so it is difficult to determine its price. It is necessary to consider all factors in detail, consult industry experts, or visit various chemical materials trading platforms, to get a more accurate price range.