What is the chemical structure of methyl-n- (methoxycarbonylmethyl) -3-sulfamoylthiophene-2-carboxylate?

This is the chemical structure of "methyl-N- (methoxycarbonyl methyl) -3 -aminosulfonylthiophene-2 -carboxylic acid ester". According to the classical style of "Tiangong Kaiwu", let me explain in detail.

In this compound, the "methyl" is a group formed by one carbon and three hydrogens, which is active and often the basic component of organic molecules. "N- (methoxycarbonyl methyl) ", this part is quite critical. "Methoxycarbonyl" is a methoxy group connected to a carbonyl group, which has unique chemical properties. The carbonyl group is a carbon-oxygen double bond, which is rich in reactivity, and the methoxy group affects its electron cloud distribution. The "methyl" is attached to the nitrogen atom, and this structure affects the polarity and steric resistance of the molecule.

Furthermore, "3-aminosulfonylthiophene-2-carboxylate". "Thiophene" is a sulfur-containing five-membered heterocyclic ring with aromatic properties. The electron cloud distribution on the ring is unique, giving the molecule special stability and reactivity. "3-aminosulfonyl", aminosulfonyl group is -SO -2 NH -2, connected to the No. 3 position of the thiophene ring, affects the electron cloud density of the thiophene ring, and then affects the nucleophilic and electrophilic reactivity of the whole molecule. " 2-Carboxylic acid ester ", indicating that it has a carboxylic acid ester structure at position 2 of the thiophene ring, and the carboxylic acid ester has the characteristics of hydrolysis. This structure also plays an important role in the solubility and reactivity of the molecule as a whole.

In this way, the chemical structure of methyl-N- (methoxycarbonyl methyl) -3-aminosulfonylthiophene-2-carboxylic acid ester interacts with each other to jointly determine its chemical properties and reactivity, and may have important uses in organic synthesis and pharmaceutical chemistry.

What are the main uses of methyl-n- (methoxycarbonylmethyl) -3-sulfamoylthiophene-2-carboxylate?

Methyl - N - (methoxycarbonylmethyl) -3 - sulfamoylthiophene - 2 - carboxylate is an organic compound. It has a wide range of uses in the field of medicinal chemistry, or is a key intermediate. Due to the various functional groups contained in its structure, such as carboxyl esters, sulfonamide groups, etc., it can be chemically modified to create compounds with specific biological activities. In the process of drug development, or by adjusting its structure to improve the affinity and selectivity of drugs to specific targets, it lays the foundation for the development of new drugs.

In the field of materials science, it may also have potential uses. Due to its unique molecular structure, it may endow materials with specific physical and chemical properties. For example, in the preparation of some functional polymer materials, the introduction of this compound may improve the solubility, thermal stability or optical properties of the material.

In the field of organic synthesis, as an important raw material, it can participate in many chemical reactions, and construct more complex organic molecular structures through various reaction pathways. Its rich functional groups provide organic synthesis chemists with a variety of reaction check points, helping to build a diverse library of compounds, and contributing to the exploration of novel organic compounds and the expansion of organic synthesis methodologies.

What is the preparation method of methyl-n- (methoxycarbonylmethyl) -3-sulfamoylthiophene-2-carboxylate?

To prepare methyl-N- (methoxycarbonyl methyl) -3 -aminosulfonylthiophene-2 -carboxylic acid ester, the method is as follows:

First take an appropriate amount of 3-aminosulfonylthiophene-2 -carboxylic acid and place it in a clean reaction vessel. Dissolve it in an organic solvent such as dichloromethane or N, N -dimethylformamide (DMF) to form a homogeneous solution.

Take another methoxycarbonyl methylation reagent, such as methyl bromoacetate, and slowly drop it into the above solution according to the appropriate stoichiometric ratio. At the same time, add an appropriate amount of base, such as potassium carbonate or triethylamine, to promote the reaction. The function of alkali is to capture the acidic hydrogen produced in the reaction system and promote the positive progress of the reaction.

During the reaction process, the reaction needs to be maintained at an appropriate temperature. Generally speaking, it can be adjusted between room temperature and 50 ° C according to the specific reaction situation. During this period, stirring is continued to make the reactants fully contact and speed up the reaction rate.

After the reaction continues for a period of time, the reaction process is monitored by thin chromatography (TLC) or other suitable analytical methods. When the raw material point is basically eliminated, the reaction is considered to be roughly completed.

After the reaction is completed, pour the reaction solution into an appropriate amount of water and extract the product with an organic solvent. Combine the organic phases and wash them with water and saturated salt water successively to remove impurities. Subsequently, the organic phase is dried with anhydrous sodium sulfate or magnesium sulfate, and the desiccant is filtered off.

Finally, the organic solvent is removed by reduced pressure distillation to obtain a crude product. After refining by column chromatography or recrystallization, pure methyl-N- (methoxycarbonyl methyl) -3 -aminosulfonylthiophene-2 -carboxylate is obtained. The whole process needs to pay attention to the control of reaction conditions, the dosage of reagents, and the standardization of operation to obtain satisfactory yield and purity.

What are the physical properties of methyl-n- (methoxycarbonylmethyl) -3-sulfamoylthiophene-2-carboxylate

Methyl-N- (methoxycarbonyl methyl) -3 -aminosulfonylthiophene-2 -carboxylic acid ester, this is an organic compound. Its physical properties are quite important and are related to many practical applications.

This compound is mostly solid at room temperature, and its appearance is usually white to off-white crystalline powder. Looking at its texture, it is delicate and uniform, and it feels smooth to touch.

Melting point is of great significance for determining its purity and stability. Experiments have determined that the melting point of this compound is in a specific range. This property helps to precisely control the conditions in the synthesis and purification process to ensure the quality of the product.

Solubility is also a key property. In common organic solvents, such as ethanol, acetone, etc., it exhibits a certain solubility, but its solubility in water is limited. This solubility difference is widely used in the field of drug research and development and chemical production. For example, it can be separated, purified or prepared into a specific dosage form by selecting a suitable solvent.

Its density is slightly larger than that of water, and it will settle at the bottom in a liquid system. This property needs to be considered in operations involving mixed systems.

In addition, the compound has certain stability. Under normal storage conditions, its chemical properties are relatively stable, and it is not easy to react with common components in the air. In case of extreme chemical environments such as strong acids and strong bases, chemical reactions may occur, resulting in structural changes and physical properties.

In summary, the physical properties of methyl-N- (methoxycarbonyl methyl) -3 -aminosulfonylthiophene-2 -carboxylic acid esters are rich and diverse, and each property is interrelated. It plays a unique role in different fields, laying the foundation for its practical application.

What is the price range of methyl-n- (methoxycarbonylmethyl) -3-sulfamoylthiophene-2-carboxylate in the market?

I don't know the price range of "methyl - n -%28methoxycarbonylmethyl%29 - 3 - sulfamoylthiophene - 2 - carboxylate" in the market. This is a specific compound in the chemical industry, and its price is affected by many factors. First, the difficulty of preparation. If the synthesis steps are complicated, special raw materials and conditions are required, the cost will be high, and the price will also rise. Second, the amount of market demand. If an industry has strong demand for this product, the supply will exceed the demand, and the price may rise; if the demand is low, the price may decline. Third, the purity requirements are high. High purity is difficult to prepare, and the price is often higher.

However, I do not have past transaction records and current market data on hand, so it is difficult to determine its price range. If you want to know the exact price of this product, you can consult chemical product suppliers, relevant trading platforms, or ask industry insiders in chemical professional forums. They may be able to provide a more accurate price range based on their own experience and information.