methyl 6-bromo-1-benzothiophene-2-carboxylate

Methyl 6-bromo-1-benzothiophene-2-carboxylic acid ester is a key compound in the field of organic synthesis. It has a wide range of uses and has important applications in medicine, pesticides, materials science and many other fields.
In pharmaceutical chemistry, this compound is often used as a key intermediate for the synthesis of new drugs. Due to its unique chemical structure, the combination of benzothiophene ring with bromine atom and ester group endows it with specific biological activity and molecular recognition ability. Through chemical modification and reaction, complex molecular structures with specific pharmacological activities can be constructed to develop therapeutic drugs for specific diseases, such as anti-cancer, anti-inflammatory and neurological diseases.
In the field of pesticides, methyl 6-bromo-1-benzothiophene-2-carboxylate can be used to create new pesticides. Its structural properties may enable it to have biological activities such as insecticidal, bactericidal or weeding. After appropriate derivatization and formula optimization, high-efficiency, low-toxicity and environmentally friendly pesticide products can be developed, providing a powerful tool for agricultural pest control.
In the field of materials science, this compound may be used to prepare functional materials. Its special electronic structure and chemical properties may make it exhibit unique properties in the field of organic optoelectronic materials, such as in organic Light Emitting Diode (OLED), organic solar cells and other devices, providing new opportunities and possibilities for the development of materials science. By chemically modifying and assembling it, the electrical, optical and thermal properties of materials can be adjusted to meet the needs of different application scenarios.

The synthesis method of methyl 6-bromo-1-benzothiophene-2-carboxylic acid ester is not contained in the ancient book "Tiangong Kaiwu", but it contains the wisdom of creation and synthesis, which can open up the idea of synthesis.
In this case, one method can be to synthesize this product by co-heating 6-bromo-1-benzothiophene-2-carboxylic acid and methanol under acid catalysis, and carry out esterification reaction. If sulfuric acid is used as the catalyst, the two are mixed in a reaction vessel in an appropriate proportion, heated to a certain temperature, and the reaction is maintained for a period of time. Sulfuric acid can promote the dehydration and condensation of the carboxyl group in formic acid and the hydroxyl group in methanol. This process needs to be controlled by temperature. If it is too high, the side reaction will be raw, and if it is too low, the reaction will be slow.
The second method can first prepare 6-bromo-1-benzothiophene-2-formyl chloride, which is obtained by the action of sulfinyl chloride with 6-bromo-1-benzothiophene-2-formic acid. Then formyl chloride reacts with methanol in the presence of a base, which can bind the acid and shift the reaction to the right. Commonly used bases such as pyridine can obtain the target product methyl 6-bromo-1-benzothiophene-2-carboxylic acid ester.
Or a benzothiophene skeleton can be constructed by multi-step reaction of suitable halogenated aromatics and sulfur-containing reagents, and then a carboxyl group can be introduced, and then esterified. This approach has many steps, but it can be flexibly adjusted according to the raw materials and conditions. The synthesis method is not one, and the optimal method needs to be selected according to the actual situation, considering factors such as raw materials, cost, yield and purity.

Methyl-6-bromo-1-benzothiophene-2-carboxylic acid ester, this is an organic compound. Its physical properties are crucial and are related to many chemical applications.
Looking at its properties, under normal temperature and pressure, it is mostly solid or crystalline. This form gives it a certain stability and is easier to store and operate. Its melting point is of great significance for identification and purification. After many experiments, the melting point is roughly in a specific temperature range. This characteristic becomes an important indicator when identifying the authenticity and purity of the compound.
When it comes to solubility, it shows different solubility behaviors in organic solvents. In common organic solvents, such as dichloromethane, chloroform and other halogenated hydrocarbon solvents, it has good solubility. This property provides convenience for organic synthesis reactions. Because many reactions need to be carried out in homogeneous solution, good solubility can ensure that the reactants are fully contacted, accelerate the reaction process, and improve the reaction efficiency. However, the poor solubility in water is mainly due to the large proportion of hydrophobic groups in its molecular structure, and the weak interaction between water molecules and the compound.
Furthermore, its density is also an important physical property. Although the exact value varies slightly due to measurement conditions, it is generally within a specific range. Density information is crucial in operations such as separation and extraction involving the compound. Knowing its density, you can choose a suitable separation method. If the density is significantly different from other liquids, you can use liquid separation and other means to achieve separation.
In addition, the compound also has a specific refractive index. Refractive index is one of the characteristic constants of substances, and can be used as an important reference when identifying and analyzing the compound. Different purity methyl-6-bromo-1-benzothiophene-2-carboxylic acid esters have subtle changes in refractive index, so their purity can be evaluated.

The market price of methyl-6-bromo-1-benzothiophene-2-carboxylate is difficult to say exactly. The price of this substance often varies due to many factors.
First, the price of raw materials has a great impact. If the price of the starting materials required for the synthesis of this compound, such as specific thiophenols and halogenated aromatics, fluctuates, the price of the product will also fluctuate. If the supply of raw materials is tight, the price will rise; on the contrary, if the supply is sufficient, the price may stabilize or decline.
Second, the preparation process is also key. If the process used is complex, requiring multi-step reactions, special catalysts or harsh reaction conditions, the cost will be high, and the product will be sold at a high price. And if there is a newly created efficient and simple process, the cost will be reduced, and the price is expected to drop.
Third, the market supply and demand situation determines the price. If the demand for this compound in the fields of medicine, materials and other fields increases sharply, but the supply is limited, the price will rise. On the contrary, if the market is saturated and there is little demand, merchants may reduce prices to clear inventory.
Fourth, the price varies from manufacturer to manufacturer. Well-known large factories may have higher prices than ordinary manufacturers due to strict product quality control and high brand reputation. Small factories compete for market share or attract customers at low prices.
Looking at the theory of "Tiangong Kaiwu", everything is related to the production, supply and demand of things. The price of methyl-6-bromo-1-benzothiophene-2-carboxylate follows this principle. It is uncertain with the changes of the above factors, and it is difficult to say the exact market price.

Methyl-6-bromo-1-benzothiophene-2-carboxylic acid ester, this is a fine chemical substance. Its storage conditions are quite critical, which is related to the stability and quality of the substance.
According to the ancient method, a cool, dry and well-ventilated place should be used as a storage place. Those who are cool should avoid the disturbance of high temperature. If they are under the hot summer sun, high temperature can easily cause chemical reactions of the substance, damage its chemical structure, reduce its purity and performance. Dry place can prevent the erosion of humid air. Water vapor can easily cause adverse reactions such as hydrolysis, which can cause the substance to deteriorate. As for good ventilation, it can disperse volatile gases in time to prevent them from accumulating and causing danger, and keep the air fresh and do not mix impurities.
Furthermore, store the substance away from fire sources, heat sources and strong oxidants. Fire sources and heat sources can cause it to heat up, or cause disasters such as combustion and explosion. Strong oxidants have strong oxidizing properties. Contact with the substance or trigger a violent oxidation reaction, destroying its properties.
When storing, it should also be separated from acids, bases and other substances. Acids and bases are chemically active, contact with them, or reactions such as acid-base neutralization occur, changing the chemical composition.
Packaging must be tight. Sealed containers can be selected, such as glass bottles, plastic bottles, etc., to block air and moisture intrusion and ensure that the substance is stable and intact during storage.
Follow the above storage conditions to properly store methyl-6-bromo-1-benzothiophene-2-carboxylate, so that it can maintain good quality and performance for a long time.