methyl 5-formylthiophene-3-carboxylate

Methyl-5-formylthiophene-3-carboxylic acid esters have a wide range of uses. In the field of organic synthesis, it is a crucial intermediate. Due to its unique structure, it contains thiophene rings and functional groups of formyl and carboxyl groups, which can be derived from many chemical reactions.
First, in the field of pharmaceutical chemistry, this compound can be used as a starting material for lead compounds. By modifying and modifying its structure, drug molecules with specific biological activities can be created. For example, by chemically modifying the formyl group or carboxyl group, the lipophilicity, water solubility and interaction with biological targets of the molecule can be adjusted, and various drugs such as antibacterial, anti-inflammatory or anti-tumor can be developed.
Second, in the field of materials science, methyl-5-formylthiophene-3-carboxylate can be used to prepare functional polymer materials. Due to its good electronic conductivity, its introduction into the polymer structure is expected to endow the material with unique electrical and optical properties. For example, materials with photoelectric conversion functions can be prepared and applied to solar cells and other devices to improve the efficiency of light energy conversion.
Furthermore, it also has important uses in the synthesis of fine chemicals. It can be used to synthesize special fragrances, dyes, etc. By ingeniously designing the reaction path and taking advantage of the reactivity of its functional groups, fine chemicals with novel structures and unique properties can be synthesized to meet the needs of different industries for special chemicals.
In summary, methyl-5-formylthiophene-3-carboxylic acid esters have shown important value in many fields such as organic synthesis, medicinal chemistry, materials science, and fine chemical synthesis, providing a key material basis and research starting point for the development of various fields.

Methyl-5-formylthiophene-3-carboxylic acid ester is a unique compound in the field of organic chemistry. Looking at its physical properties, this compound is usually a white to light yellow crystalline powder under normal conditions, which endows it with certain stability and operability.
When it comes to melting point, the melting point of this compound is quite critical, because melting point can often be used as an important indicator for identifying its purity and characteristics. After many experiments, its melting point usually falls within a specific temperature range, which has a significant impact on its behavior under different reaction conditions. When the external temperature approaches or reaches the melting point, the physical state of the compound will change, gradually transforming from a solid state to a liquid state, which is of great significance to the process and results of related chemical reactions.
Furthermore, solubility is also an important aspect to consider the physical properties of this compound. In organic solvents, such as common ethanol and dichloromethane, methyl-5-formylthiophene-3-carboxylate exhibits a certain solubility. In ethanol, with moderate stirring, some compounds can be dissolved to form a uniform solution; in dichloromethane, its solubility is better, and it can be dispersed and dissolved more quickly and fully. However, in water, the solubility of the compound is minimal. This property is closely related to the molecular structure of the compound. The characteristics of the groups in the molecule determine the differences in the interaction between it and different solvent molecules, which in turn leads to differences in solubility.
In addition, the density of this compound is also a physical property that cannot be ignored. Although its density value is relatively stable under certain conditions, it has a potential impact on the practical application of the compound, such as the stratification of the mixed system and the hydrodynamic properties of the reaction system. The determination and mastery of density is helpful for the precise design and control of related chemical processes.
Overall, the physical properties of methyl-5-formylthiophene-3-carboxylic esters, such as morphology, melting point, solubility, and density, are interrelated and work together to lay the foundation for their applications in organic synthesis, materials science, and many other fields. In-depth understanding of these physical properties will enable better control of this compound to maximize its effectiveness in various chemical processes.

The synthesis method of methyl-5-formylthiophene-3-carboxylic acid ester is not detailed in "Tiangong Kaiji", but it can be deduced by analogy and related principles according to ancient chemical methods.
Synthesis of various esters in the past, the method of esterification of Chang Lai. To obtain methyl-5-formylthiophene-3-carboxylic acid ester, you can first find a compound containing thiophene structure and a modifiable group at the corresponding position. If carboxylic acid and methanol containing thiophene ring are used as raw materials, and strong acid as catalyst, such as sulfuric acid, is heated to promote its esterification reaction. This is because the nucleophilic substitution can occur between the acid and the alcohol under the catalysis of the strong acid, the hydroxyl group of the carboxyl group is combined with the hydrogen of the alcohol to form water, and the remainder is connected to form an ester.
However, this compound contains formyl group, and the formyl group is more active. Compounds containing carboxyl groups and thiophene rings can be prepared first, and then formyl groups can be introduced through specific steps. For example, thiophene-3-carboxylic acid is used as the starting material, and methanol is first esterified to form methylthiophene-3-carboxylic acid ester. Then, Vilsmeier-Haack reagent composed of formylation reagents, such as N, N-dimethylformamide (DMF) and phosphorus oxychloride (POCl), is used to introduce formyl groups at the 5-position of the thiophene ring under appropriate temperature and reaction conditions. In this process, Vilsmeier-Haack reagent first forms an active intermediate and attacks the thiophene ring for electrophilic substitution, resulting in the target product methyl-5-formylthiophene-3-carboxylate.
Alternatively, a thiophene structure containing formyl groups can be constructed first, and then esterified. For example, 5-formylthiophene-3-carboxylic acid is first synthesized from suitable raw materials, and then esterified with methanol to obtain the target product. This synthesis method requires detailed consideration of the reaction conditions at each step. Temperature, reagent dosage, and reaction time are all related to success or failure. Careful operation is required to achieve the synthesis of the target product.

The market price of methyl-5-formylthiophene-3-carboxylic acid ester is not easy to change. The price of this compound often varies due to various reasons.
First, the difficulty of preparation is different. If the preparation method is difficult, rare raw materials and strict conditions are required, and the price must be high; if the method is simple and the raw materials are easy to obtain, the price may be slightly flat.
Second, the situation of demand and supply is different. If there are many people in the market who need this, and there are few suppliers, the price will rise; if the supply exceeds the demand, the price will decrease.
Third, the purity of the quality is also tied to the price. The higher the purity, the more suitable it is for fine experiments or production, and the higher the price; if the purity is slightly lower, the price may be lower.
The view of "Tiangong Kaiwu", although it is not described in detail, the price of various products is related to supply and demand and manufacturing. By extension, the price of methyl-5-formylthiophene-3-carboxylate is also the same. To know its exact price, you should carefully study the market of chemical raw materials and consult the supplier to obtain it. Or you can explore its recent price status on the platform of chemical trading, or you can look at the price of similar products as a reference, so that you can know its approximate value.

Methyl-5-formylthiophene-3-carboxylic acid ester is a kind of organic compound. The rules of its storage conditions are related to the quality and existence of this substance.
When this substance is stored, the first environment is dry. Moisture is easy to cause it to deteriorate, so it should be placed in a dry place, away from moisture, so as to prevent it from being melted and changed by water.
The temperature must be appropriate. Excessive temperature can accelerate its reaction, or cause decomposition, polymerization, etc.; too low temperature, although it may slow down its change, it may also change the state of matter and damage its original properties. It is usually around room temperature, about 20 to 25 degrees Celsius, which is the temperature suitable for storage. If conditions permit, temperature control is better in a narrow range.
Furthermore, light is also the main reason. This object is sensitive to light or direct exposure to strong light, which can initiate chemical reactions and damage its structure. Therefore, it should be stored in a dark place, or stored in a light-shielding device, such as a brown bottle, to protect it from light damage.
Also, the storage place should be protected from other objects. Do not coexist with strong oxidants, reducing agents and other reactive substances to prevent accidental transformation.
All these, dry environment, temperature control, protection from light, and protection from disturbance, are all essential for the storage of methyl-5-formylthiophene-3-carboxylate. Only by doing so can the quality of this substance be maintained for a long time.