What is the chemical structure of methyl 5-chloro-n- (methoxycarbonylmethyl) -3-sulfamoylthiophene-2-carboxylate

Methyl-5-chloro-N- (methoxycarbonyl methyl) -3-aminosulfonyl thiophene-2-carboxylic acid ester, this is an organic compound. To clarify its chemical structure, it is necessary to analyze the parts of its name. "Methyl" indicates a hydrocarbon group -CH < unk >. "5-chloro" refers to the presence of a chlorine atom at the 5th carbon position of the thiophene ring. The thiophene ring is a sulfur-containing five-membered heterocycle. "N- (methoxycarbonyl methyl) " means that the nitrogen atom is connected to a methoxycarbonyl methyl group, and the structure of this group is -CH < unk > COOCH < unk >. " 3-Aminosulfonyl "indicates that there is an aminosulfonyl-SO _ 2O NH _ 2 attached to the 3-carbon position of the thiophene ring." 2-carboxylate "refers to the 2-carbon position of the thiophene ring with a carboxylate-COOCH. Its chemical structure can be roughly depicted as: with the thiophene ring as the core, the No. 5 carbon is connected to a chlorine atom, the No. 3 carbon is connected to an aminosulfonyl group, the No. 2 carbon is connected to a carboxylate group containing a methoxy group, and the nitrogen atom is connected to a methoxy carbonyl methyl group. The structure of this compound is complex, and the characteristics and interactions of each group will affect its chemical and physical properties.

What are the main uses of methyl 5-chloro-n- (methoxycarbonylmethyl) -3-sulfamoylthiophene-2-carboxylate

Methyl 5-chloro-N- (methoxycarbonyl methyl) -3-aminosulfonyl thiophene-2-carboxylic acid ester, an organic compound. It has a wide range of uses in the field of medicine and is often an intermediate in drug synthesis. Drug developers take advantage of the unique structure of this compound to construct molecules with specific biological activities or act on specific targets to treat various diseases, such as inflammation and tumors. Due to the active groups such as aminosulfonyl and carboxyl esters in the molecular structure, the physical and chemical properties and biological activities of the compound can be changed by chemical modification, which meets the needs of drug design.

In the field of materials science, this compound may participate in the preparation of functional materials. Due to its structural properties, it may endow materials with special electrical, optical or chemical properties. For example, in organic optoelectronic materials, or improve the charge transport performance of materials and improve the photoelectric conversion efficiency, it is used in the manufacture of Light Emitting Diodes, solar cells and other devices.

In the field of agricultural chemistry, or provide key raw materials for the creation of pesticides. After rational structure optimization, or develop pesticides that have high-efficiency inhibition or killing effects on specific pests or pathogens, and are relatively friendly to the environment, contributing to sustainable agricultural development. This compound has important application value in many fields due to its diverse chemical activities and structural modifiability, providing key support for scientific research and industrial production.

What is the synthesis method of methyl 5-chloro-n- (methoxycarbonylmethyl) -3-sulfamoylthiophene-2-carboxylate

To prepare methyl 5-chloro-N- (methoxycarbonyl methyl) - 3-aminosulfonyl thiophene-2-carboxylic acid ester, the method is as follows:

First, various raw materials need to be prepared, such as compounds containing thiophene structure, chlorination reagents, reagents containing methoxycarbonyl methyl, aminosulfonylation reagents, etc. The purity and quality of raw materials are related to the effectiveness of the reaction, so they need to be carefully selected.

First take the substrate containing thiophene structure, put it in a suitable reaction vessel, and add an appropriate amount of solvent. This solvent needs to be able to dissolve the substrate well and not interfere with the reaction. Then, under the appropriate temperature and stirring conditions, slowly add the chlorination reagent dropwise. Temperature control is extremely critical. If it is too high, side reactions will occur, and if it is too low, the reaction will be slow. After adding dropwise, continue to stir, so that the chlorination reaction can be fully carried out. The reaction process can be monitored by thin-layer chromatography until the raw material point almost disappears, and the reaction is complete.

After the chlorination reaction is completed, the reaction solution should be properly handled, or extracted or distilled to remove the unreacted reagents and by-products to obtain a pure 5-chlorothiophene derivative.

Subsequently, this derivative is mixed with a reagent containing methoxycarbonyl methyl and an appropriate amount of alkali is added to provide a suitable environment for the reaction. The type and dosage of alkali need to be determined by exploration to achieve the best reaction effect. When heating up to a specific temperature and the number of reactions, pay close attention to the reaction phenomenon during this process, and take samples regularly for testing.

After the reaction is completed, the crude product can be obtained through separation and purification steps. The crude product is refined by means of recrystallization, column chromatography, etc., and finally the pure methyl 5-chloro-N- (methoxycarbonyl methyl) -3-aminosulfonylthiophene-2-carboxylate is obtained.

This method of synthesis involves many steps, and the reaction conditions at each step need to be precisely controlled. A slight difference in the pool will affect the yield and purity of the product. Therefore, when operating in practice, be cautious and adhere to the procedures.

What are the physical and chemical properties of methyl 5-chloro-n- (methoxycarbonylmethyl) -3-sulfamoylthiophene-2-carboxylate

Methyl 5-chloro-N- (methoxycarbonyl methyl) -3-aminosulfonyl thiophene-2-carboxylic acid ester, which is an organic compound. Looking at its structure, it contains a thiophene ring, and there is a carboxylic acid methyl ester group at the 2nd position of the thiophene ring, an aminosulfonyl group at the 3rd position, a chlorine atom at the 5th position, and a nitrogen atom is connected to a methoxycarbonyl methyl group.

In terms of physical properties, because of its many polar groups, such as aminosulfonyl groups, ester groups, etc., it is speculated that it may have a certain solubility in water. However, because the molecule contains aromatic thiophene rings and chlorine atoms, hydrophobicity also exists, resulting in its solubility or limited. Its melting point and boiling point are affected by the intermolecular force, and the polar groups can form hydrogen bonds, which enhances the intermolecular force, causing the melting point and boiling point to be higher.

When it comes to chemical properties, the sulfur atoms in aminosulfonyl groups have lone pairs of electrons and are nucleophilic to a certain extent, which can participate in reactions such as nucleophilic substitution. When the ester group encounters an acid or a base, it can be hydrolyzed. The hydrolysis is reversible under acid catalysis, and the hydrolysis is complete under alkali catalysis, resulting in corresponding carboxylic salts and alcohols. Although the thiophene ring is aromatic, it is more active than the benzene ring. Under specific conditions, an electrophilic substitution reaction can occur, and due to the presence of substituents at the 3rd and 5th positions, the substitution check point may be affected. Chlorine atoms can be used as leaving groups to participate in nucleophilic substitution reactions and are replaced by other groups.

Methyl 5-chloro-n- (methoxycarbonylmethyl) -3-sulfamoylthiophene-2-carboxylate market prospects

Methyl 5-chloro-N- (methoxycarbonyl methyl) -3-aminosulfonylthiophene-2-carboxylate, this is an organic compound. In today's market, its prospects are quite promising.

The development of the Guofu chemical industry has created a growing demand for fine chemicals. Due to its unique chemical structure, this compound is widely used in the fields of medicine and pesticides. In pharmaceutical research and development, it may be used as a key intermediate to help create new drugs to deal with various diseases, so pharmaceutical companies are paying more and more attention to it.

In the field of pesticides, with its special properties, high-efficiency and low-toxicity pesticide products may be developed, which can not only ensure the harvest of crops, but also meet the needs of environmental protection. Therefore, pesticide manufacturers have also considered incorporating it into the production chain.

Furthermore, with the continuous advancement of science and technology, the process of synthesizing this compound is also improving day by day, and the production cost is expected to gradually decrease, which will undoubtedly further expand its market application scope. The innovation of production technology has enabled the production to be improved and the quality to be more stable, thus enhancing its competitiveness in the market.

However, although the market prospect is good, it also faces some challenges. For example, special reaction conditions and raw materials may be required in the synthesis process, which requires high professional quality of production equipment and technicians. And market competition should not be underestimated. Many chemical companies have laid out related fields to seize market share.

Overall, methyl 5-chloro-N- (methoxycarbonyl methyl) - 3-aminosulfonylthiophene-2-carboxylic acid esters have both opportunities and challenges in the market. If we can overcome technical problems and grasp market trends, we will be able to emerge in related industries and seek broad development space.