Methyl 5-chloro-3-(chlorosulfonyl)-2-thiophenecarboxylate

Methyl 5-chloro-3- (chlorosulfonyl) -2-thiophenecarboxylate, this is an organic compound with unique physical properties. Its appearance is often white to light yellow crystalline powder, fine texture, under specific light or weak luster.
Looking at its melting point, it is about [X] ° C. This characteristic makes it gradually melt from solid to liquid at the corresponding temperature, and the temperature is relatively stable, which is an important basis for identifying and purifying the compound. In terms of boiling point, it is about [X] ° C. At this temperature, the compound is rapidly converted from liquid to gas, and the intermolecular force overcomes the external pressure to achieve phase transition.
Solubility is also a key physical property. It has good solubility in organic solvents, such as dichloromethane, chloroform, N, N-dimethylformamide (DMF) and other organic solvents, and can be dissolved in a suitable ratio to form a homogeneous solution. This is due to the existence of specific intermolecular forces between the compound and the organic solvent, such as van der Waals force, hydrogen bond, etc., which promote the mutual fusion of the two. However, its solubility in water is poor, because there are few hydrophilic groups in the molecular structure of the compound, and the hydrophobic thiophene ring and chlorine atoms account for a large proportion, making it difficult to form an effective interaction with water molecules, so it is difficult to dissolve in water.
In addition, the density of this compound is about [X] g/cm ³, which reflects its mass characteristics per unit volume, and has a great influence on material separation, storage and transportation. And because of its chlorine and sulfur atoms, it presents characteristic absorption peaks in infrared spectroscopy, nuclear magnetic resonance and other spectra, which can be used to accurately determine its molecular structure and purity. All these physical properties lay a solid foundation for the in-depth study and rational application of methyl 5-chloro-3- (chlorosulfonyl) -2-thiophenecarboxylate.

The chemical synthesis method of 5-chloro-3- (chlorosulfonyl) -2-thiophene carboxylic acid ester covers many ways. One method can first take the appropriate thiophene derivative as the starting material. If the thiophene containing a specific substituent is used as the group, the chlorosulfonyl group is first introduced in a suitable reaction environment. This step requires the selection of an appropriate sulfonation reagent, such as chlorosulfonic acid, and is carried out at a suitable temperature and reaction time, so that the chlorosulfonyl group can be precisely introduced at a specific position in the thiophene ring.
Then, in the subsequent reaction, the methyl ester group is introduced. The corresponding carboxylic acid and methanol can often be used, and the esterification reaction can be carried out in the presence of the catalyst. The catalyst can be selected as a protonic acid such as sulfuric acid, or a specific Lewis acid. By controlling the reaction conditions, such as temperature and the proportion of reactants, the reaction proceeds in the direction of generating the target product.
Another method can first construct the thiophene ring structure. Using small molecules containing sulfur atoms and suitable substituents as raw materials, thiophene rings are formed by cyclization reaction, and chlorosulfonyl groups and formyl groups are introduced in sequence during or after cyclization. Among these, the control of cyclization reaction conditions is extremely critical, and factors such as reactant activity, solvent selection, and pH of the reaction system must be considered.
Furthermore, other heterocyclic compounds are used as the starting point, and the structure of the target molecule is gradually constructed through a series of functional group transformations. This process requires familiarity with the mechanisms and conditions of various organic reactions, and careful design of reaction routes to efficiently synthesize methyl 5-chloro-3- (chlorosulfonyl) -2-thiophene carboxylate. In short, the method of chemical synthesis is expensive to design and precisely control the reaction conditions.

Methyl 5-chloro-3- (chlorosulfonyl) -2-thiophenecarboxylate is an important chemical substance in the field of organic synthesis. Its main uses are quite extensive, and it is often a key intermediate in the synthesis of specific drugs in the field of medicinal chemistry. Because the thiophene ring is connected to many active groups, it gives it unique chemical properties and can participate in various chemical reactions to construct complex molecular structures with biological activity, which helps to create new drugs and is of great significance for the treatment of diseases.
In the field of materials science, this compound may be used to prepare special functional materials. The chlorosulfonyl group and other groups contained in it can be modified by chemical reactions to give the material special properties, such as improving the stability and solubility of the material or giving it specific optical and electrical properties, etc., which play an important role in the research and development of advanced materials.
In addition, in the field of fine chemicals, it is also an important raw material for the synthesis of high value-added fine chemicals. Through ingenious design of chemical reactions and the use of their structural properties, a series of fine chemicals with unique functions can be prepared to meet the needs of different industrial and consumer markets. In summary, methyl 5-chloro-3-chlorosulfonyl-2-thiophenecarboxylate plays an indispensable role in many key areas due to its unique structure and reactivity, and is of great significance for promoting technological progress and industrial development in related fields.

Methyl 5-chloro-3- (chlorosulfonyl) -2-thiophenecarboxylate This product needs to pay attention to many key matters during storage and transportation.
It may have certain chemical activity. When storing, it should be placed in a cool, dry and well-ventilated place. Avoid direct exposure to strong light, which may cause photochemical reactions and cause it to deteriorate. Temperature also needs to be strictly controlled. Excessive temperature may cause it to decompose or accelerate chemical reactions, and too low temperature may cause its physical state to change, affecting quality.
The storage environment must be kept away from fire and heat sources, because it may be flammable or contact with fire and heat sources will cause a violent reaction, which may cause fire or explosion. And it should be stored separately from oxidizing agents, reducing agents, alkalis, etc. Contact with these substances can easily trigger chemical reactions and endanger safety.
During transportation, the packaging must be solid and reliable to prevent material leakage caused by damage to the container. When handling, it should be handled lightly and unloaded lightly, and it must not be operated brutally to avoid damage to the packaging. The means of transportation also need to be clean and dry, free of residual impurities and substances that may react with them. And the environmental conditions such as temperature and humidity should be closely monitored during transportation, and adjusted in time according to the actual situation. Therefore, the safety and quality of 5-chloro-3- (chlorosulfonyl) -2-thiophenecarboxylate during storage and transportation.

Methyl 5-chloro-3- (chlorosulfonyl) -2-thiophene carboxylate is difficult to determine in the market price range. Due to changes in the market, it is fickle, and many factors can affect its price.
The market of chemical raw materials in the past, the rise and fall of the price often depends on the supply and demand ends. If there are many demand for this product, and the supply is small, the price will rise; on the contrary, if the supply exceeds the demand, the price will be depressed.
In addition, the cost of production is also the key. The price of raw materials, energy consumption, and labor can all cause the cost to rise and fall, which in turn affects the market price. And the difficulty of the process is also related to the cost. If the process is complicated and the required technology and equipment are all fine, the cost will be high and the price will be high.
Furthermore, the direction of policy and the stability of the current situation are also related to the price. Policy encouragement or restrictions can affect production and sales; the current situation is turbulent, the logistics will be blocked, and the price will also change.
In summary, the market price of methyl 5-chloro-3- (chlorosulfonyl) -2-thiophenecarboxylate may vary from time to time, or from place to place, and it is difficult to have a fixed number. It is necessary to carefully observe the current market situation in order to obtain a more accurate price.