methyl 5-bromothiophene-2-carboxylate

Methyl-5-bromothiophene-2-carboxylic acid ester, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to its unique structure, it contains bromine atoms and carboxylic acid ester groups, which can be derived by various chemical reactions.
First, in nucleophilic substitution reactions, bromine atoms are very active and easily replaced by nucleophilic reagents. Such as reacting with alcohols and amines, ether or amine derivatives can be formed. This property allows chemists to build complex organic molecular structures based on it, laying the foundation for the creation of new drugs and the development of new materials.
Second, it also plays an important role in the construction of carbon-carbon bond reactions. Such as participating in palladium-catalyzed coupling reactions, combining with various olefins, aromatics and other coupling reagents to achieve efficient construction of carbon-carbon bonds, thereby extending the carbon chain, enriching the diversity of molecular structures, and providing a powerful way for the preparation of functional materials and total synthesis of natural products.
Furthermore, because carboxylic acid ester groups can be converted by hydrolysis, alcoholysis and other reactions, they become important starting materials in the synthesis of carboxylic acids and esters with specific structures, meeting the needs of specific structural compounds in different fields. In short, methyl-5-bromothiophene-2-carboxylic acid esters are of great significance in the field of organic synthesis and promote the continuous progress of chemical science and related industries.

The synthesis methods of methyl-5-bromothiophene-2-carboxylic acid esters vary, and the details are as follows.
First, thiophene is used as the initial raw material. After the bromination reaction of shilling thiophene, under appropriate reaction conditions, such as using liquid bromine as the brominating agent, in a suitable solvent (such as dichloromethane), at low temperature and with the help of a catalyst (such as iron powder), thiophene can be introduced into the bromine atom at the 5-position to obtain 5-bromothiophene. Subsequently, 5-bromothiophene is reacted with carbon dioxide under specific conditions. For example, in the presence of a strong base (such as n-butyllithium), an organolithium reagent is first formed, then reacted with carbon dioxide, and then acidified to obtain 5-bromothiophene-2-carboxylic acid. Finally, 5-bromothiophene-2-carboxylic acid and methanol are catalyzed by concentrated sulfuric acid, esterified, heated and refluxed to obtain methyl-5-bromothiophene-2-carboxylic acid ester.
Second, 2-thiophene carboxylic acid is used as the starting material. Methyl 2-thiophenecarboxylate was obtained by esterification of 2-thiophenecarboxylic acid with methanol, and then brominated with N-bromosuccinimide (NBS) as brominating agent. Under the initiation of benzoyl peroxide (BPO), bromine atoms were refluxed in a suitable solvent (such as carbon tetrachloride), and bromine atoms were introduced at the 5-position of the thiophene ring to obtain the target product, methyl-5-bromothiophene-2-carboxylate. Third, if 5-bromo-2-halothiophene is used as raw material, methyl-5-bromothiophene-2-carboxylate can be synthesized by carbonylation reaction with carbon monoxide and methanol under the action of transition metal catalyst (such as palladium catalyst) under certain pressure and temperature conditions. This process requires strict control of the reaction conditions to ensure the safe use of carbon monoxide and the smooth progress of the reaction.

Methyl-5-bromothiophene-2-carboxylic acid ester, which is a kind of organic compound. Its physical properties are as follows:
Under normal temperature and pressure, it often takes the form of a colorless to light yellow liquid, or a crystalline solid, which is related to the specific purity and the ambient temperature. Its melting point and boiling point are important physical constants. Generally speaking, the melting point is within a specific temperature range, which varies slightly depending on the specific structure and purity of the compound. The boiling point also has a corresponding value. At standard atmospheric pressure, the substance will change from liquid to gaseous at a specific boiling temperature.
In terms of solubility, it exhibits different solubility properties in organic solvents. Organic solvents such as ether, dichloromethane, and chloroform are well miscible with them. This is because the molecular structure of the compound contains groups that interact with organic solvents, so it is easy to disperse in organic solvents. However, the solubility in water is poor, because water is a polar solvent, and the polarity of the compound is relatively weak. According to the principle of "similar miscibility", it is difficult to dissolve in water.
Density is also one of its physical properties. Its density is either greater than or less than that of water compared with water, depending on the mass of the molecule and the way it is deposited between the molecules. This property is of great significance in practical applications when operations such as delamination are involved.
In addition, the compound may have a specific odor. Although the description of your mileage may vary, it can usually be perceived as having a certain smell of organic compounds. And its stability to light and heat is also a key physical property. Under light or heat conditions, chemical reactions such as decomposition and isomerization may occur, affecting its chemical properties and applications. Understanding these physical properties is crucial for the synthesis, purification, storage and application of the compound.

Methyl-5-bromothiophene-2-carboxylic acid ester, the price of this product in the market is difficult to break. The price of the market is often changed due to many reasons, such as the source of the material, the skill of the process, the state of supply and demand, and even the change of time.
If the source of the material, the abundance of the production area, and the quality of the minerals can all make the price different. Those who are easy to obtain and of high quality may have a slightly lower price; those who are difficult to harvest and of poor quality will have a higher price.
The skill of the process is also a major reason. Making good use of new technologies and being proficient in the process can save labor and materials, reduce its cost, and reduce the price accordingly. If the old law is followed, the cost of complex materials will be high.
The state of supply and demand is particularly critical. If there are many seekers and few suppliers, the price will rise; if the supply exceeds the demand, and the stock of goods is difficult to sell, the price will drop.
The change of times also has an impact. Current political regulations, business policies, and changes in exchange rates can all make the price state different.
Therefore, in order to know the price of methyl-5-bromothiophene-2-carboxylate in the market, it is necessary to consider various factors in detail, or consult industry experts, and explore the market to obtain a more accurate number. It is difficult to determine its price based on a few words.

Methyl-5-bromothiophene-2-carboxylic acid ester is an important compound in organic chemistry. Its storage conditions are related to the stability and quality of this substance, which cannot be ignored.
This substance should be stored in a cool, dry and well-ventilated place. If it is cool, it is easy to exacerbate its chemical reaction due to high temperature, or cause the risk of decomposition and deterioration. If the temperature is too high, the molecular movement will increase, and the stability of chemical bonds will be damaged. Therefore, it should be controlled at an appropriate low temperature. Generally speaking, 15 ° C to 25 ° C is appropriate.
Dry environment is also critical. Moisture in the air, or hydrolysis and other reactions with methyl-5-bromothiophene-2-carboxylic acid ester, cause its structure to change, affecting its chemical properties and uses. Therefore, the humidity of the storage place should be low, and the relative humidity should generally be maintained between 40% and 60%.
Well ventilated to avoid local accumulation of volatile gas to prevent the formation of flammable and explosive mixed gases. Methyl-5-bromothiophene-2-carboxylic acid ester may have certain volatility. If the ventilation is not smooth, the volatile gas will accumulate in a limited space, and it will be dangerous in case of open flame or static electricity.
and must be stored separately from oxidizing agents, acids, alkalis and other substances. Due to the chemical properties of methyl-5-bromothiophene-2-carboxylic acid ester, it is prone to chemical reaction with the above substances, resulting in safety accidents or product deterioration. When storing, a specific area should be planned, each substance should be placed in sections, and obvious signs should be set up.
In addition, storage containers should not be ignored. Corrosion-resistant materials, such as glass or specific plastic containers, should be selected to ensure that the containers are well sealed and prevent leakage. During storage, regular inspections should also be made to see if there is any leakage or deterioration, so that they can be dealt with in time. Only in this way can methyl-5-bromothiophene-2-carboxylate be properly stored to ensure its quality and safety.