Methyl 5-amino-1-benzothiophene-2-carboxylate

Methyl-5-amino-1-benzothiophene-2-carboxylate is an important member of organic compounds. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry. Due to its special molecular structure, it can provide a unique structural basis for drug synthesis and help create drug molecules with specific biological activities.
In the field of materials science, it has also made a name for itself. Or it can be modified by specific chemical reactions to have special optical and electrical properties, and then applied to the research and development of materials such as organic Light Emitting Diodes and sensors. The structural properties of this compound give it the possibility to exhibit diverse reactivity under different reaction conditions, providing rich options for material performance optimization.
also has its uses in pesticide chemistry. With the specific impact on the physiological activities of harmful organisms, through rational design and synthesis, high-efficiency, low-toxicity and environmentally friendly pesticide products may be developed, which can help agricultural pest control and ensure crop yield and quality. In short, methyl-5-amino-1-benzothiophene-2-carboxylate has important application value in many scientific fields, providing an important material basis for related research and industrial development.

Methyl-5-amino-1-benzothiophene-2-carboxylic acid ester is one of the organic compounds. Its physical properties are of great value for investigation.
Looking at its properties, it is mostly in a solid state at room temperature. This is due to the intermolecular force, which makes its structure relatively stable, so it is a solid state. The value of its melting point is extremely critical for the identification of this substance. After precise experimental determination, a specific melting point can be obtained. By virtue of the melting point, the purity can be judged. The higher the purity, the more stable and accurate the melting point.
When it comes to solubility, it shows a certain solubility in organic solvents, such as ethanol, acetone, etc. This is due to the specific interactions between the molecular structure of the compound and the organic solvent molecules, such as van der Waals forces, hydrogen bonds, etc., which make the two blend with each other. However, in water, the solubility is quite limited, because the polarity of the water molecule is quite different from the molecular polarity of the compound, it is difficult to form an effective interaction.
Furthermore, its density is also one of the important physical properties. The determination of density can help to understand its material properties and behavior in different media. Through experimental means, the exact density value can be obtained, which is of reference significance in chemical production, material applications and other fields.
In addition, the color state of this substance also needs attention. Usually white or off-white, this color characteristic may be related to the absorption and reflection characteristics of molecular structure, which can provide intuitive basis for practical application and identification. In short, the many physical properties of methyl-5-amino-1-benzothiophene-2-carboxylate are indispensable for its research and application.

To prepare methyl-5-amino-1-benzothiophene-2-carboxylate, the method is as follows:
First take an appropriate amount of 5-nitro-1-benzothiophene-2-carboxylic acid and place it in the reactor. In the kettle, an alcohol solvent, such as anhydrous ethanol, is used as the medium, and an appropriate amount of catalyst, such as palladium-carbon catalyst, is added. Seal the reactor, introduce hydrogen gas, maintain a certain pressure and temperature, such as hydrogen pressure of 3-5 atm and 50-70 ℃, carry out catalytic hydrogenation reaction. This reaction aims to reduce nitro groups to amino groups. After several hours, the reaction progress is monitored by thin-layer chromatography. When the raw material point disappears, it shows that 5-nitro-1-benzothiophene-2-carboxylic acid has been mostly converted to 5-amino-1-benzothiophene-2-carboxylic acid.
Then, the resulting 5-amino-1-benzothiophene-2-carboxylic acid is transferred into another reaction vessel, an appropriate amount of methanol is added, and then thionyl chloride or concentrated sulfuric acid is added dropwise as an esterification reagent. At an appropriate temperature, such as 60-80 ° C, when the reaction number is refluxed. During this period, pay close attention to the reaction phenomenon. When the reaction is completed, cool the reaction liquid. Then, pour the reaction liquid into ice water, extract the product with an organic solvent, collect the organic phase, dry it with anhydrous sodium sulfate, and remove the organic solvent by distillation under reduced pressure to obtain the crude product of methyl-5-amino-1-benzothiophene-2-carboxylic acid.
Finally, the crude product is refined by recrystallization with a suitable organic solvent, such as a mixed solvent of ethyl acetate and petroleum ether, for recrystallization operation, multiple washes of crystals, and after drying, pure methyl-5-amino-1-benzothiophene-2-carboxylate can be obtained.

I don't know the price range of "Methyl 5 - amino - 1 - benzothiophene - 2 - carboxylate" in the market. There are many traditional processes in "Tiangong Kaiwu", which rarely involve the price of these chemicals. In today's market, the price of this chemical may vary depending on purity, output, supply and demand, and manufacturers. In the chemical raw material market, the price of high purity is high or high, and the price of low purity is low. If the demand for this substance is strong and the output is small, the price will rise; on the contrary, if the supply exceeds the demand, the price will drop. To know the exact price, you should consult the chemical raw material supplier, the chemical product trading platform, or the chemical market survey report to get the price range.

The Quality Standard of methyl-5-amino-1-benzothiophene-2-carboxylic acid ester is of great significance in many fields such as chemical industry and medicine. The Quality Standard covers a number of key elements.
The first is the appearance. The appearance of this substance should be a specific form, such as white to off-white crystalline powder, without impurities or foreign matter visible to the naked eye, so as to ensure its purity and uniformity, which has a profound impact on subsequent processing and application.
The second is purity. The purity of this substance is extremely critical and usually requires a very high level, such as not less than 98% or even higher. High purity can ensure the accuracy and stability of chemical reactions, and in the field of medicine, it is also a core indicator of drug efficacy and safety. A common method for determining purity is high-performance liquid chromatography (HPLC), which uses precise analysis to determine the impurity content to determine whether the purity is up to standard.
Melting point is also an important indicator. The melting point of methyl-5-amino-1-benzothiophene-2-carboxylate should be within a specific range, such as [specific melting point range]. The determination of this range can assist in the determination of the purity and crystal structure of the substance. If the melting point deviates from the established range, or implies that there are impurities interfering with the crystal structure and affecting the properties of the substance.
In addition, the inspection of relevant substances is indispensable. It is necessary to carefully detect the intermediates, by-products and other related substances that may remain in the production process, and strictly limit their content to prevent adverse effects on product quality and application results. In addition to HPLC, the detection method may also use gas chromatography (GC), etc., to fully control the status of the relevant substances. < Br >
Moisture content cannot be ignored. Moderate moisture content is critical to maintaining material stability and physical properties. Moisture is generally required to be controlled within a certain limit. If it does not exceed [specific moisture content value], the Karl Fischer method is often used to determine the moisture content to ensure that the moisture content meets Quality Standards.