Methyl 4-bromo-3-hydroxythiophene-2-carboxylate

Methyl 4-bromo-3-hydroxythiophene-2-carboxylic acid ester is one of the organic compounds. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
First, in the field of pharmaceutical chemistry, molecular structures with specific biological activities can be constructed through specific reaction paths, laying the foundation for the development of new drugs. Because thiophene rings and their associated functional groups can interact specifically with targets in organisms, or help to find lead compounds with antibacterial, anti-inflammatory, anti-tumor and other pharmacological activities.
Second, in the field of materials science, it can participate in the preparation of functional materials. With its unique chemical structure, it is expected to impart special photoelectric properties to materials through polymerization or compounding with other materials, such as being used in organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices to improve the properties of materials.
Third, in the fine chemical industry, it can be used to synthesize fine chemicals, such as special fragrances, dyes, etc. Because its structure can provide rich reaction check points, through chemical modification, fine chemicals with specific colors, odors or other special properties can be prepared to meet the needs of different industrial and consumer fields.

The method of preparing methyl 4-bromo-3-hydroxythiophene-2-carboxylate has not been detailed in ancient books, but there are several ways to find it in today's chemical understanding.
First, the corresponding thiophene derivative can be started. First, a suitable carboxylating agent, such as carbon dioxide, works synergistically with a metal agent to introduce the carboxyl group at the 2-position of the thiophene ring, and then form a methyl ester. Then find a suitable brominating agent, such as N-bromosuccinimide (NBS), to introduce the bromine atom at the 4-position. As for the hydroxyl group, it can be introduced at an appropriate stage by means of protection and deprotection strategies without disturbing other functional groups.
Second, the thiophene ring can also be constructed by multi-step reaction from the raw materials containing suitable substituents. First, based on the compound containing carboxyl and bromine atoms, the thiophene skeleton is constructed through cyclization reaction, and at the same time, the hydroxyl group is introduced at the 3-position, and the methyl ester is formed. This process requires fine regulation of the reaction conditions, such as temperature, solvent, catalyst, etc., to achieve the ideal yield and selectivity.
Preparation of this product requires careful investigation of the mechanism of each step of the reaction, careful selection of reagents and conditions, and consideration of the feasibility and economy of the reaction. Although it is difficult to find its details in ancient books, the chemical knowledge today is extensive, and the preparation method can be explored according to this reason.

Methyl 4 - bromo - 3 - hydroxythiophene - 2 - carboxylate is an organic compound. Its physical properties are crucial for the application of this compound in many fields.
This compound has a specific melting point, and the value of the melting point is extremely important for the identification and purification of this compound. Due to the different purity of the compound, the melting point may vary. Knowing the exact melting point, in laboratory synthesis and industrial production processes, the purity of the product can be determined by the melting point.
Its boiling point is also an important physical property. The boiling point reflects the temperature required for the compound to change from liquid to gas under a specific pressure. This is of great significance for setting suitable temperature conditions when using separation and purification methods such as distillation. By controlling the temperature near the boiling point, the compound can be effectively separated from the mixture.
The solubility of the compound in common organic solvents is also a key physical property. If it is easily soluble in some organic solvents, such as ethanol, acetone, etc., it is convenient to select a suitable solvent in the organic synthesis reaction to promote the smooth progress of the reaction. Because the suitable solvent can ensure that the reactants are fully mixed, the reaction rate and yield can be improved.
In addition, its appearance is usually solid or liquid, and physical characteristics such as color and odor can also be used as the basis for preliminary identification. Appearance descriptions such as white solid or colorless liquid can help researchers preliminarily judge the state and purity of the compound. The physical properties of Methyl 4 - bromo - 3 - hydroxythiophene - 2 - carboxylate, such as melting point, boiling point, solubility and appearance, play an important role in organic synthesis, drug discovery, materials science and many other fields, laying the foundation for the preparation, separation, identification and application of compounds.

Methyl 4-bromo-3-hydroxythiophene-2-carboxylic acid ester, this is an organic compound with multiple unique chemical properties.
Among its structures, the thiophene ring is the core, which endows the compound with certain aromaticity. The conjugation system of the thiophene ring makes the electron cloud distributed uniformly, which in turn affects its chemical activity and stability. The characteristics of the aromatic ring make the compound exhibit a unique reaction path in many reactions, such as electrophilic substitution reactions.
Bromine atoms are attached to the fourth position of the thiophene ring, and bromine is a strong electron-absorbing group. The electron cloud density of the thiophene ring is affected by induction and conjugation effects. This change decreases the electron cloud density at a specific position on the ring. During the electrophilic substitution reaction, the electron cloud density of the adjacent and para-position bromine atoms is relatively high, and the electrophilic reagents are easy to attack this position. Therefore, the bromine atom has a positioning and guiding effect on the reaction check point. At the same time, the bromine atom can participate in a variety of nucleophilic substitution reactions, which is an important active check point for the construction of new chemical bonds. If it is substituted with nucleophilic reagents, a variety of compounds containing different functional groups can be derived. The hydroxyl group at the
3 position has an active hydrogen atom and is somewhat acidic. The hydroxyl oxygen atom has a lone pair of electrons and can form hydrogen bonds with other molecules, which has a great impact on the physical properties of the compound In chemical reactions, hydroxyl groups can undergo esterification, etherification, oxidation and other reactions. For example, reacting with carboxylic acids or acyl chlorides to form esters is a common method for constructing ester bonds in organic synthesis; oxidation can be converted into carbonyl groups, expanding the reaction type and derivation direction of compounds.
2-position carboxylic acid methyl ester group, the carbonyl group in the methyl ester group has certain electrophilicity, and α-hydrogen has a certain acidity, which can occur reactions such as ester condensation. Under alkaline conditions, α-hydrogen can be removed by bases to form carbon negative ions, which can then react with other electrophilic reagents to construct more complex molecular structures. The carboxylic acid methyl ester group can be converted into carboxylic acid by hydrolysis reaction or alcohol by reduction reaction, which provides a variety of ways for the structural modification and functional expansion of compounds.
Methyl 4-bromo-3-hydroxythiophene-2-carboxylate presents rich chemical properties due to the interaction and synergy of various functional groups, and has broad application prospects in the field of organic synthesis.

I have not heard the exact price of "Methyl 4 - bromo - 3 - hydroxythiophene - 2 - carboxylate" in the market. The price of this compound may vary due to difficulty in preparation, different needs, and changes in market conditions.
To know its price, you can visit the official website of chemical reagent suppliers, such as Sinopharm Group Chemical Reagent Co., Ltd., search banner reagent network, etc., and consult their customer service to get a recent quotation. Or refer to relevant scientific research literature, check past purchases, or be able to know the price range. However, the price listed in the literature may vary depending on time and place, and is for reference only. < Br >
If it is a rare and difficult compound to synthesize, the price may be high; if it is easy to prepare, abundant in yield, and widely demanded, the price may be close to the people. And bulk purchase, the price may also be discounted. Therefore, it is difficult to determine the exact price of its price. Only by carefully checking the market conditions can we get a near-real price.