Methyl 4-(aminosulfonyl)-5-methylthiophene-3-carboxylate

The Chinese name of this compound is "methyl 4- (aminosulfonyl) -5-methylthiothiophene-3-carboxylate". Its chemical structure can be analyzed step by step from the name. "Thiophene" is a five-membered heterocyclic ring containing a sulfur atom and is the core skeleton of this compound. "4- (aminosulfonyl) " indicates that an aminosulfonyl group (-SO -2 NH -2) is connected at position 4 of the thiophene ring, which is composed of a sulfonyl group connected to an amino group. "5-methylthio" indicates that there is a methylthio group (-SCH 🥰) at position 5 of the thiophene ring, that is, a sulfur atom is connected to a methyl group. " 3-Carboxylate "pointed out that the carboxylate structure at the 3rd position of the thiophene ring is a carboxylic acid ester structure, here specifically the methyl ester group (-COOCH 😉), that is, the ester group formed by the carboxyl group and methanol. The whole structure is centered on the thiophene ring, and specific groups are connected at different positions, which together constitute the unique chemical structure of" methyl 4- (aminosulfonyl) -5-methylthiophene-3-carboxylate ".

Methyl 4- (aminosulfonyl) -5-methylthiothiophene-3-carboxylic acid ester has a wide range of uses. In the field of pharmaceutical and chemical industry, it can be used as a key intermediate to create many specific drugs. For example, when developing drugs with antibacterial and anti-inflammatory effects, this compound can closely fit with specific biological targets due to its unique chemical structure, and undergo a series of reaction transformations to obtain final drugs with specific pharmacological activities, providing powerful weapons for human beings to fight diseases.
In the field of materials science, it has also emerged. Because it contains special functional groups, it can participate in material synthesis reactions, giving materials unique properties. For example, in the preparation of conductive polymer materials, the addition of this substance in an appropriate amount may improve the electrical conductivity of the material, making it useful in the field of electronic devices, such as the manufacture of better electrode materials.
In agricultural chemistry, there are also potential uses. After reasonable modification and transformation, new pesticides may be developed. By interacting with specific biomolecules in pests or plants, the purpose of efficient insecticide or plant growth can be achieved, escorting agricultural harvests, and it is expected to reduce the adverse impact on the environment, which is in line with the development of green agriculture.

To prepare methyl 4- (aminosulfonyl) -5 -methylthiophene-3 -carboxylic acid ester, there are many methods, and the above is one or two.
First, it can be started from raw materials containing the corresponding thiophene structure. First, modify the specific position on the thiophene ring with appropriate reagents and introduce methylthiophenyl groups. This step can be achieved by nucleophilic substitution reaction. The nucleophilic reagent containing methylthio groups reacts with suitable halogenated thiophene derivatives in a suitable solvent in the presence of a base. For example, using potassium carbonate as a base and acetonitrile as a solvent, heat and stir to make the nucleophilic reagent attack the halogenated site to generate 5-methylthio-substituted thiophene derivatives.
Then, the derivative is subjected to aminosulfonylation. Aminosulfonyl chloride reagents can be used to react in organic solvents such as dichloromethane in the presence of an organic base such as triethylamine. Triethylamine can neutralize the hydrogen chloride generated by the reaction, promoting the forward progress of the reaction, thereby introducing an aminosulfonyl group at a specific position in the thiophene ring.
Finally, an esterification reaction is carried out to obtain the target product. Methanol is selected as the esterification reagent. Under the action of concentrated sulfuric acid or p-toluenesulfonic acid and other catalysts, the thiophene carboxylic acid is heated and refluxed to form methyl 4- (aminosulfonyl) -5 -methylthiophene-3 -carboxylic acid After the reaction is completed, the pure product can be obtained by separation and purification methods, such as column chromatography.
Second, there are also other paths. Starting from simple raw materials, thiophene rings are constructed through multi-step reactions. First, thiophene rings are formed by condensation reaction with sulfur-containing and carbon-source reagents, and then methylthio groups, aminosulfonyl groups and ester groups are introduced in turn. Although this path is slightly complicated, the raw materials are easily available, and the reaction conditions of each step are relatively mild, it is also one way to synthesize the compound.

The physical properties of methyl 4- (aminosulfonyl) -5-methylthiothiophene-3-carboxylic acid esters are especially crucial for chemical study. This compound is in a solid state and is relatively stable at room temperature and pressure. Looking at its appearance, it is mostly white or off-white powder, delicate and uniform, like a light snow falling in the early winter, light and pure.
Its melting point is quite characteristic, and after fine determination, it is about within a specific temperature range. This melting point characteristic is very important in the identification and purification of this substance. When covering the compound with different purity, the melting point is slightly different, like a human fingerprint, which is its unique identification.
In addition, this substance also has unique solubility. In common organic solvents, such as ethanol, acetone, etc., it has a certain solubility. However, in water, its solubility is quite limited. The difference in solubility is just like walking in different waters, and the process is different. In an organic solvent, the interaction between molecules allows the compound to disperse and dissolve; in water, due to the poor compatibility of molecular structure and water molecules, it is difficult to dissolve.
Its density is also one of the physical properties. The density value obtained by accurate measurement reflects the compactness of its molecular accumulation. In practical application scenarios such as chemical production and preparation, this value is related to the measurement and mixing ratio of materials. It is like the cornerstone of a building. Although it is small, it is related to the stability of the whole.
In summary, the physical properties of methyl 4- (aminosulfonyl) -5 -methylthiophene-3 -carboxylate are useful and related. They are all indispensable elements in the research and application fields of chemistry.

Methyl-4- (aminosulfonyl) -5-methylthiophene-3-carboxylate, this is an organic compound. Looking at its market prospects, it needs to be considered many times.
First discuss its application field. In the field of medicine, or a key intermediate for the synthesis of specific drugs. Today's pharmaceutical industry is booming, and the demand for novel and highly effective drugs is increasing. If this compound can help develop drugs with good efficacy and few side effects, the market demand may be considerable. For example, in the synthesis of anti-tumor drugs or anti-infective drugs, if it is an indispensable link, pharmaceutical companies must demand it in order to ensure production and supply, and with the deepening of research and development and the approval of new drugs for the market, the dosage may increase steadily.
In the field of pesticides, it may also play an important role. At present, the demand for high-efficiency, low-toxicity, and environmentally friendly pesticides in agriculture is on the rise. If this compound can participate in the synthesis of pesticides with such properties, such as products that can accurately kill pests, inhibit pathogens, and have little impact on the ecological environment, it will be favored by pesticide manufacturers. With the promotion of green agriculture, the demand for such pesticide raw materials is expected to increase, and the market for this compound may expand accordingly.
However, there are also many challenges. First, the synthesis process may be complex. If the synthesis steps are cumbersome and the conditions are harsh, the production cost will remain high, affecting its market competitiveness. Second, regulations and supervision are becoming increasingly strict. Whether it is a pharmaceutical or pesticide-related product, it needs to go through strict regulatory review from research and development to marketing. When this compound is used in the production of related products, it must meet various regulatory requirements. If it cannot meet the standards, its market application will be limited.
Furthermore, the market competition situation cannot be ignored. If there are alternatives with similar functions and lower cost and better performance on the market, the road to promotion of this compound may be full of thorns. However, if the company can make efforts in technological innovation, optimize the synthesis process, improve product quality, and actively explore the market to meet customer needs, methyl-4- (aminosulfonyl) -5-methylthiophene-3-carboxylate still has considerable market prospects and has found a place in the organic synthesis-related industries.