Methyl 3-methylthiophene-2-carboxylate

Methyl-3-methylthiophene-2-carboxylic acid ester, this substance has a wide range of uses. In the field of pharmaceutical synthesis, it is often a key intermediate. Gein thiophene has a special structure and can significantly change the physical, chemical and biological activities of compounds when introduced into specific molecules. Such as the preparation of some antibacterial and anti-inflammatory drugs, methyl-3-methylthiophene-2-carboxylic acid esters can be reacted in a series to build a core structure of drug activity and help the development of new drugs.
It also has important functions in the field of materials science. Because of its unique electronic properties and chemical stability, it can participate in the synthesis of organic optoelectronic materials. For example, in the development of organic Light Emitting Diode (OLED) materials, this material can be used as a raw material to synthesize substances with specific luminous properties, improve the luminous efficiency and stability of OLED devices, and contribute to the progress of display technology.
Furthermore, in the field of fine chemicals, it is an important raw material for the preparation of high-end fragrances and special coatings. With its special odor and chemical properties, unique fragrances can be tuned; for coating preparation, it can give coatings excellent chemical corrosion resistance and wear resistance, meeting high-end industrial and civilian needs. In summary, methyl-3-methylthiophene-2-carboxylic acid esters play an important role in many fields such as medicine, materials, and fine chemicals, and are of great significance for promoting technological innovation and development in related industries.

The method of preparing methyl 3-methylthiophene-2-carboxylic acid ester has been explored by many scholars in the past, but now it is detailed by you.
First, 3-methylthiophene-2-carboxylic acid and methanol are used as raw materials, and concentrated sulfuric acid is used as a catalyst to carry out the esterification method. This reaction needs to be carried out at a suitable temperature, usually in a heated reflux state. Concentrated sulfuric acid can promote the reaction to move in the direction of ester formation, but it is highly corrosive, and the post-reaction treatment is slightly more complex, so careful separation and purification are required.
Second, 3-methylthiophene-2-formyl chloride is reacted with methanol. First, 3-methylthiophene-2-formyl chloride is prepared, which is often obtained by reacting thionyl chloride with 3-methylthiophene-2-carboxylic acid. Then it is mixed with methanol, the reaction is more rapid, and the side reactions are relatively few, and the yield is also observable. However, formyl chloride is irritating and corrosive, so it must be handled with caution and in a well-ventilated place.
Third, 3-methylthiophene-2-carboxylic acid anhydride is reacted with methanol. The reaction activity of carboxylic acid anhydride with alcohol is quite high, and it can be carried out under mild conditions. The use of strong acids or strong corrosive reagents can be avoided, and the purity of the product can be easily improved. However, the preparation of carboxylic anhydride may require additional steps, and the cost may increase.
All these methods have advantages and disadvantages. In actual preparation, when the availability of raw materials, cost considerations, equipment conditions and product purity requirements and many other factors, the appropriate method can be carefully selected to achieve the purpose of preparation.

The physical properties of methyl-3-methylthiophene-2-carboxylic acid ester are unique. At room temperature, this substance is mostly in a liquid state, with a clear and transparent appearance, like water in a mirror, slightly fluid, and can flow freely in a container.
Its density is larger than that of common water. If you compare water with it, it is like a stone to water, and it will sink to the bottom when placed in water. Looking at its color, it is almost colorless, just like the pure emptiness in the morning, without the slightest variegated color.
Smell it, it has a unique smell, although it is not pungent and intolerable, but it is also different from ordinary tasteless things. This smell is specific and indescribable. It is like the unique smell of precipitation over time, and it cannot be known without smelling.
Solubility is also one of its significant physical properties. In organic solvents, such as common ethanol and ether, it is quite compatible, just like fish in water, miscible without hindrance, showing good solubility characteristics. However, in water, it is extremely insoluble, and the two are like ice and fire, repelling each other, and there is almost no appearance of fusion.
In addition, its boiling point is also an important physical parameter. Under certain pressure conditions, when the corresponding boiling point is reached, it will evaporate like a cloud and transform from liquid to gaseous state. The value of this boiling point is its inherent physical property, which plays an important guiding role in the identification and separation of substances. Its melting point is also fixed. When the temperature drops to a certain value, it will condense into ice like water on a cold night, changing from a flowing state to a solid state. This melting point is also the key to identify this substance. All these physical properties are important ways to understand methyl-3-methylthiophene-2-carboxylic acid esters, helping us to understand the essence and characteristics of this substance.

Methyl 3-methylthiophene-2-carboxylic acid ester is one of the organic compounds. It has many unique chemical properties.
Looking at its structure, the thiophene ring is connected to the ester group, giving the compound a specific chemical activity. In terms of reactivity, the ester group is prone to hydrolysis. Under acidic or basic conditions, this hydrolysis can be carried out. In an acidic medium, 3-methylthiophene-2-carboxylic acid and methanol can be obtained by hydrolysis; in an alkaline environment, alkali-catalyzed hydrolysis will produce carboxylic acid and methanol, and subsequent acidification treatment can obtain the corresponding carboxylic acid.
thiophene ring also exhibits unique chemical behavior. Due to its aromatic properties, electrophilic substitution reactions can occur. For example, in halogenation reactions, halogen atoms can replace hydrogen atoms on thiophene rings under the action of suitable catalysts. In view of the fact that methyl is the power supply group, the electron cloud density of thiophene rings will increase, which in turn makes electrophilic substitution reactions more likely to occur, and the substitution positions tend to be ortho or para-sites of methyl groups.
In addition, the compound can also participate in the reverse reaction of esterification reactions, that is, transesterification reactions with alcohols under specific conditions to generate new ester compounds. This transesterification reaction has a wide range of uses in organic synthesis, allowing the preparation of esters with different structures. At the same time, because of its sulfur-containing atoms, it may play a unique role in some reactions involving sulfur atoms, such as participating in the construction of complex organic molecular structures containing sulfur, providing more possible paths for organic synthetic chemistry.

I searched for all kinds of goods in the market, but I didn't get the exact price of "Methyl 3 - methylthiophene - 2 - carboxylate". This may be due to the lack of supply and demand of this product in the market and the lack of wide circulation, so it is difficult to find its price. Or it is a special product for fresh use, and merchants rarely have reserves, so it is difficult to determine the price.
In the past, as stated in "Tiangong Kaiwu", the price of the product varies depending on the place of origin, season, cost of work, and supply and demand. By extension, if "Methyl 3 - methylthiophene - 2 - carboxylate" has a wide range of production, low cost of work, and more supply than demand, the price may be cheap; if the place of origin is rare, the production is complex, and the demand is more than the supply, the price will be high.
However, if you want to know the price, or you should consult a business that specializes in this industry, or visit a platform for trading chemical materials, or seek information from a chemical research institution, they may have this price.