methyl 3-chloro-1-benzothiophene-2-carboxylate

Methyl-3-chloro-1-benzothiophene-2-carboxylic acid ester, this is an organic compound. Its chemical properties are unique and contain many wonders.
Looking at its structure, the benzothiophene ring endows it with certain stability and special electronic effects. The thiophene ring is inherently aromatic. After fusing with the benzene ring, the aromatic system can be expanded, which makes the electron cloud distribution of the compound more complex. The chlorine atom is substituted at the 3rd position, and the chlorine atom has strong electronegativity, which will affect the electron cloud density on the benzothiophene ring, so that the electron cloud density of its adjacent and para-potential is relatively reduced, thus affecting the reactivity of the compound.
In terms of reactivity, the methyl ester part of its carboxyl group is active. The ester group can undergo hydrolysis reaction, and under the catalysis of acid or base, it can react with water to form corresponding carboxylic acids and methanol. Under alkaline conditions, the hydrolysis reaction is more rapid and thorough, because the hydroxide ion has a strong nucleophilic attack on ester carbonyl carbons.
In addition, in view of the electron cloud distribution of the benzothiophene ring, it can participate in the electrophilic substitution reaction. However, due to the electron-absorbing effect of the chlorine atom, the reaction check point is different from that of the unsubstituted benzothiophene, and the reaction tends to occur at a relatively high electron cloud density.
At the same time, various chemical bonds contained in this compound, such as C-Cl bonds, C-O bonds, etc., can be broken and rearranged under specific conditions, triggering a variety of chemical reactions, exhibiting unique chemical charm.

Methyl 3-chloro-1-benzothiophene-2-carboxylic acid ester, which is an important compound in the field of organic synthesis. Its common uses involve many aspects.
In the field of medicinal chemistry, it is often used as a key intermediate to create various drugs. Due to the unique structure of benzothiophene, it has good biological activity and pharmacological properties. By modifying and derivatizing the structure of this compound, drugs with specific curative effects can be developed, such as antibacterial, anti-inflammatory, and anti-tumor drugs.
In the field of materials science, it also has its uses. Due to its special chemical structure, it can participate in the preparation of materials with specific photoelectric properties. For example, it is used in the synthesis of organic semiconductor materials, which have broad application prospects in devices such as organic Light Emitting Diode (OLED) and organic solar cells, and can impart unique electrical and optical properties to the materials.
In addition, in the field of pesticide chemistry, it also plays an important role. It can be used as a raw material to synthesize new pesticides, and by virtue of its structural characteristics, it can inhibit or kill certain pests or pathogens, helping to control pests and diseases in agricultural production.
In short, methyl 3-chloro-1-benzothiophene-2-carboxylate is widely used in many fields such as medicine, materials, and pesticides, and has made great contributions to promoting the development of related fields.

To prepare methyl 3-chloro-1-benzothiophene-2-carboxylic acid ester, the following ancient method can be used.
First take 1-benzothiophene-2-carboxylic acid and place it in an appropriate reaction vessel. With an appropriate amount of methanol as the solvent, add a catalyst amount of concentrated sulfuric acid, this concentrated sulfuric acid can promote the esterification reaction. After mixing the two evenly, heat to reflux. During the heating process, the carboxyl group of 1-benzothiophene-2-carboxylic acid is esterified with the hydroxyl group of methanol, and a molecule of water is removed to form methyl 1-benzothiophene-2-carboxylic acid ester.
Subsequently, the resulting methyl 1-benzothiophene-2-carboxylic acid ester is chlorinated. The methyl 1-benzothiophene-2-carboxylic acid ester is dissolved in a suitable organic solvent, such as dichloromethane. Chlorine gas is slowly introduced at low temperature and in the presence of a suitable catalyst, such as iron powder or iron chloride. Chlorine gas undergoes a substitution reaction with methyl 1-benzothiophene-2-carboxylic acid ester, and the chlorine atom replaces the hydrogen atom at position 3 on the benzothiophene ring to obtain methyl 3-chloro-1-benzothiophene-2-carboxylic acid ester.
After the reaction is completed, the product needs to be separated and purified. The reaction mixture is first washed with a suitable alkali solution, such as sodium carbonate solution, to neutralize the unreacted sulfuric acid and possible acidic impurities. Then the organic phase is separated with a separation funnel, and the organic phase is dried with anhydrous sodium sulfate to remove the moisture. Finally, the pure methyl 3-chloro-1-benzothiophene-2-carboxylate was obtained by vacuum distillation or column chromatography.

What you are inquiring about is the market price range of "methyl 3 - chloro - 1 - benzothiophene - 2 - carboxylate". This compound, called methyl 3 - chloro - 1 - benzothiophene - 2 - carboxylate, is used in the market of chemical raw materials, and its price often changes due to many reasons.
First, purity is essential. If the purity is extremely high, it is close to analytical purity, and there are few impurities, it can be used in fine chemical experiments, high-end pharmaceutical synthesis, etc., and the price must be high. Or up to tens to hundreds of gold per gram. However, if the purity is slightly lower, it is only suitable for ordinary chemical production, and the price should be sharply reduced, or only a few gold per gram.
Second, the trend of supply and demand is also heavy. If the demand for this product in the fields of pharmaceutical research and development increases greatly, but the supply is limited, the price will rise. On the contrary, if the supply exceeds the demand, the price will decline.
Third, the production process is related to the cost. If the preparation method is complicated, the raw materials are rare, the energy consumption is quite large, the cost is high, and the price is not low.
Furthermore, the impact of the purchase quantity is very small. Bulk procurement, due to economies of scale, the unit price may be discounted. Small retail, the price is often high.
Overall, its market price range, small retail and high purity, per gram or more than 100 yuan; bulk purchase and purity suitable for general chemicals, per gram or a few yuan to tens of yuan. However, this is only a rough estimate, the actual price, but also need to carefully observe the market conditions, merchants offer and other factors.

Methyl-3-chloro-1-benzothiophene-2-carboxylic acid esters are organic compounds, and there are indeed many key matters to be paid attention to during storage and transportation.
Bear the brunt, and the temperature and humidity of the storage environment are of paramount importance. This compound should be stored in a cool, dry and well-ventilated place. High temperatures can easily cause its chemical properties to change and even trigger decomposition reactions; high humidity environments may cause it to be damp and affect its quality. If placed in direct sunlight or humid places, the compound may deteriorate rapidly and be difficult to use for subsequent chemical synthesis and other purposes.
Secondly, because it is an organic compound, it is mostly flammable, so it is necessary to keep it away from fire and heat sources. Even if there is a slight spark, if it comes into contact with this compound, under suitable conditions, it may also cause severe combustion, causing a fire disaster and endangering the safety of personnel and property.
Furthermore, this compound may be toxic or irritating. During storage and transportation, direct contact with the human body should be strictly avoided. Operators should wear appropriate protective equipment, such as gloves, protective glasses and protective clothing, to prevent accidental contact, causing damage to the skin, eyes, etc. If it accidentally leaks, it should not be touched directly by hand, and proper cleaning measures should be taken immediately.
In addition, the choice of storage and transportation containers is also critical. Containers with good sealing performance and corrosion resistance should be used to prevent compound leakage and volatilization. If the container is not well sealed, the compound will evaporate into the air, which will not only cause material loss, but also cause pollution to the environment and may also endanger the health of surrounding personnel. At the same time, if the container material is not resistant to corrosion, it will react with the compound, which will also change the properties of the compound.
In short, methyl-3-chloro-1-benzothiophene-2-carboxylate should be treated with caution in terms of temperature and humidity, fire source heat source, personnel protection and container selection during storage and transportation, and must not be taken lightly to ensure its safety and quality.