methyl 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylate

Methyl-3-amino-5- (4-chlorophenyl) thiophene-2-carboxylic acid esters have a wide range of uses. This compound is often used as a lead compound in the field of medicine to develop new drugs. Due to its specific chemical structure or unique biological activity, it can act on specific targets in the human body, which in turn is helpful for disease treatment.
In the field of pesticides, it also has important applications. With its inhibitory effect on certain pests or pathogens, it can be developed into an efficient pesticide to help agricultural production, improve crop yield, and ensure food security. Due to its structural characteristics, it can precisely act on the physiological process of pests or pathogens and inhibit their growth and reproduction.
Furthermore, in the field of materials science, methyl-3-amino-5- (4-chlorophenyl) thiophene-2-carboxylate can be used as a raw material for the synthesis of functional materials. Through chemical modification and polymerization, materials with special optical, electrical or mechanical properties can be prepared, which can be used in electronic devices, optical devices and other fields to promote the development of materials science. From this perspective, methyl-3-amino-5- (4-chlorophenyl) thiophene-2-carboxylic acid esters have shown important uses in many fields such as medicine, pesticides, and materials science, and are of great significance to the progress of related industries.

There are currently methyl-3-amino-5- (4-chlorophenyl) thiophene-2-carboxylic acid esters, and there are various methods for preparing them. In the method of "Tiangong Kaiji", although this material is not detailed, it can be deduced according to its reasons and similar methods.
To make this product, or you can first take a suitable raw material containing thiophene structure, such as a compound containing thiophene ring, after ingenious reaction, an amino group is introduced. The introduction of amino groups can be done by means of nucleophilic substitution, and ammonia or an amino-containing reagent can be reacted with the raw material under appropriate conditions. The setting of conditions requires detailed observation of temperature, pressure, solvent, etc. If the temperature is too high, it may cause a cluster of side reactions; if the temperature is too low, the reaction will be delayed.
Then (4-chlorophenyl) is introduced. This step may be achieved by arylation, with the help of catalysts, the reaction occurs between a halide containing 4-chlorophenyl and a thiophene intermediate containing an amino group. The choice of catalyst depends on the rate and yield of the reaction. Choose a catalyst with suitable activity to make the reaction proceed efficiently.
As for the formation of carboxylic acid esters, thiophene derivatives containing carboxyl groups can be prepared first, and then esterified with methanol under the catalysis of acid or base. In acid catalysis, sulfuric acid is commonly used; in alkali catalysis, corresponding alkalis are also available. During the reaction, pay attention to the proportion of reactants and reaction time, so that the reaction is sufficient and the purity and yield of the product are improved.
Although there is no such exact preparation method in "Tiangong Kaizi", according to the ingenuity of the ancients and based on the principles of chemistry, a feasible method can also be deduced to form methyl-3-amino-5- (4-chlorophenyl) thiophene-2-carboxylate.

Methyl-3-amino-5- (4-chlorophenyl) thiophene-2-carboxylic acid ester, this is an organic compound. Looking at its physical properties, under normal temperature and pressure, it is mostly in the form of a solid state, and its melting point may vary due to factors such as intermolecular forces and crystal structure. Its color may be almost colorless or slightly white, due to the characteristics of chromophore groups in the molecular structure.
The solubility of this substance may be good in organic solvents such as dichloromethane and chloroform. Due to the principle of similar miscibility, the molecular structure of the compound and the molecules of the organic solvent can form interactions such as van der Waals force and hydrogen bonds, so it can be better miscible. However, in water, because its molecules contain hydrophobic aryl groups and other groups, the solubility is not good.
Its density is slightly larger than that of water. This is determined by the type of atoms in the molecule and the degree of close arrangement. The molecular mass is large and the structure is relatively compact, resulting in an increase in density. In addition, the stability of this compound may also be quite high. The structure of its thiophene ring and benzene ring is relatively stable. Although the amino group and carboxyl ester group have certain reactivity, it can maintain a relatively stable state under conventional conditions without specific reagents and conditions triggering. These are all methyl-3-amino-5- (4-chlorophenyl) thiophene-2-carboxylic acid esters.

Methyl 3-amino-5- (4-chlorophenyl) thiophene-2-carboxylic acid ester, this is an organic compound. Its chemical properties are quite rich and interesting.
Looking at its structure, it contains a thiophene ring, which endows the compound with unique electronic properties and stability. The conjugated system of the thiophene ring makes the electron cloud distributed evenly and enhances the stability of the molecule. At the same time, 4-chlorophenyl is connected to the fifth position of the thiophene ring, and the chlorine atom has an electron-absorbing effect, which affects the electron cloud density of the molecule and changes its chemical activity.
Furthermore, the amino group is connected to the 3 position, and the amino group is the electron supplier group, which can improve the electron cloud density of the thiophene ring, making the compound prone to electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. Because it can provide electrons to the reaction check point, it is conducive to the attack of electrophilic reagents.
And the carboxylic acid methyl ester group is at the 2 position. The carbonyl group of this ester group has an electron-absorbing conjugation effect and an induction effect, which can affect the electron cloud density of surrounding atoms, resulting in a decrease in the electron cloud density of its ortho and para-position. The ester group can undergo hydrolysis, alcoholysis, aminolysis and other reactions, and the corresponding carboxylic acid can be obtained by hydrolysis. Alcoholysis As a whole, the chemical properties of methyl 3-amino-5- (4-chlorophenyl) thiophene-2-carboxylic acid esters are determined by the interaction of functional groups. The interaction of functional groups makes the compound exhibit various chemical activities, which may have potential application value in organic synthesis, medicinal chemistry and other fields.

The price range of methyl-3-amino-5- (4-chlorophenyl) thiophene-2-carboxylic acid ester in the market is difficult to say exactly. The price of this compound fluctuates indefinitely due to various reasons such as difficulty in preparation, the price of raw materials required, and the amount of market demand.
Looking at the price of various materials in the past, if the preparation process of this compound is simple, and the raw materials are easy to obtain and cheap, its price in the market may be relatively easy. On the contrary, if the preparation process is complicated, the raw materials are scarce and expensive, or the market demand for it is strong, its price will rise.
However, it is difficult to determine the exact price range without detailed investigation of conclusive market data. To know the exact price of this compound, you need to consult the chemical raw material supplier and consult the professional chemical product trading platform information.