Methyl 2-methylthiophene-3-carboxylate

Methyl-2-methylthiophene-3-carboxylic acid ester is one of the organic compounds. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
In medicinal chemistry, this compound can be used as a starting material for the synthesis of many drug molecules. Due to the characteristics of thiophene ring and carboxylic acid ester structure, it is endowed with specific chemical activity and spatial structure, and can interact with targets in organisms to help build a molecular structure with biological activity, and then develop new drugs.
In the field of materials science, it also has important functions. Or it can be used to prepare polymer materials with special properties, through which it participates in polymerization reactions, giving the materials unique electrical, optical or mechanical properties. For example, in the preparation of organic optoelectronic materials, its structural properties can be used to improve the charge transport capacity and luminous efficiency of the materials, which can contribute to the development of organic Light Emitting Diodes (OLEDs), organic solar cells and other fields.
Furthermore, in the field of fine chemicals, it can be used as a raw material for the synthesis of fine chemicals such as fragrances and dyes. Due to its unique chemical structure, it can give products special odor or color characteristics to meet the special needs of different industries for fine chemicals. In conclusion, methyl-2-methylthiophene-3-carboxylic acid esters play an important role in many fields such as medicine, materials, and fine chemicals due to their unique chemical structure, and have made great contributions to promoting technological innovation and Product Research & Development in various fields.

The synthesis method of methyl-2-methylthiophene-3-carboxylic acid ester, although not detailed in "Tiangong Kaiji", can be deduced according to today's chemical principles and past synthesis ideas.
First, 2-methylthiophene is used as the starting material to carboxylate a specific position on the thiophene ring. This carboxylation step is often used with a suitable electrophilic reagent, such as carbon dioxide, under basic conditions and the action of a suitable catalyst, to react with 2-methylthiophene to generate 2-methylthiophene-3-carboxylic acid. For example, in an environment with a low temperature and a strong base such as butyl lithium, the lithium of 2-methylthiophene is first introduced, and then carbon dioxide is introduced, which can promote the carboxylation reaction.
Second, after obtaining 2-methylthiophene-3-carboxylic acid, convert it into the corresponding ester. For this esterification process, methanol can be selected as the alcohol source, and strong acids such as concentrated sulfuric acid are used as the catalyst. Under the condition of heating and reflux, the carboxylic acid and methanol undergo esterification reaction to form methyl-2-methylthiophene-3-carboxylic acid esters. Pay attention to controlling the temperature and time during the reaction to increase the yield and reduce side reactions. At the same time, higher active methanol derivatives such as diazomethane can also be used to achieve esterification under mild conditions. This method can avoid many problems caused by strong acid catalysis and is conducive to improving product purity.
In addition, another synthesis idea can be started from the construction of thiophene rings. With appropriate sulfur and carbon-containing raw materials, thiophene rings are constructed through multi-step reactions, and methyl and carboxyl ester groups are introduced at the same time. For example, thiophene rings are constructed by reacting 1,4-dicarbonyl compounds with vulcanization reagents, and then the substituents on the rings are modified to achieve the purpose of generating the target product. Although this process is complicated, the structure of the product can be precisely regulated to meet different synthesis needs.

Methyl 2-methylthiophene-3-carboxylic acid ester, this is an organic compound. Its physical properties are quite important, let me talk about them one by one.
Looking at its appearance, it is often a colorless to light yellow liquid. This color characteristic is quite meaningful when it is intuitively identified. Its smell, although it does not have a specific strong irritating smell, but it also has a unique smell. This smell characteristic may help the smell person to distinguish.
Talking about the melting point, this substance has a low melting point and is presented as a liquid under normal temperature. The boiling point varies depending on the specific ambient pressure, and is roughly within a specific temperature range. This melting boiling point characteristic requires careful consideration when storing, transporting, and using it.
In terms of solubility, methyl 2-methylthiophene-3-carboxylate exhibits good solubility in organic solvents, such as common organic solvents such as ethanol and ether, which can be fused with it. This property makes it possible to select suitable solvents for specific experimental purposes or production requirements in related chemical operations.
Density is also one of its important physical properties. Compared with water, its density may be different. This difference is crucial when it comes to operations such as liquid-liquid separation, and can provide a basis for the choice of operation methods.
In addition, the volatility of this substance also needs to be paid attention to. Although it is not a highly volatile substance, under specific conditions, its volatilization degree cannot be ignored. This characteristic is related to the choice of storage environment. It is necessary to ensure that the conditions such as environmental temperature and humidity are suitable to prevent the loss of substances due to volatilization or cause other problems.
All these physical properties are of value that cannot be ignored in chemical research, industrial production and related application fields. Researchers and practitioners should understand them in detail in order to make good use of this substance.

Methyl 2-methylthiophene-3-carboxylate (methyl 2-methylthiophene-3-formate) is an organic compound with the following chemical properties:
First, hydrolysis. Under the catalysis of acid or base, the hydrolysis reaction can occur. In case of alkali, if co-heated with sodium hydroxide solution, the ester group will break the bond to form 2-methylthiophene-3-formate sodium and methanol. During the reaction, the hydroxide ion attacks the carbon of the carbonyl group in the ester group, and after a series of changes, the corresponding product is finally obtained. Under acidic conditions, 2-methylthiophene-3-carboxylic acid and methanol are hydrolyzed to form 2-methylthiophene-3-carboxylic acid and methanol. In this process, protons first combine with carbonyl oxygen in the ester group to enhance the positive electricity of carbonyl carbon, promote water attack, and finally realize hydrolysis.
Second, esterification is reversible. As an ester, it can undergo ester exchange reaction with alcohol under acid catalysis and heating conditions. If it is co-heated with ethanol under sulfuric acid catalysis, a new ester 2-methylthiophene-3-carboxylic acid ethyl ester and methanol can be formed. This reaction is a reversible reaction, and the equilibrium needs to be shifted towards the formation of the target product by means of continuous removal of the product.
Third, substitution reaction. The hydrogen atom on the thiophene ring has a certain activity due to the distribution of the ring electron cloud and the influence of methyl and ester groups. Under appropriate catalyst and reaction conditions, an electrophilic substitution reaction can occur. If catalyzed by ferric chloride, it can be substituted with bromine, and the bromine atom can replace the hydrogen at a specific position on the thiophene ring to form a bromogenic product. The specific substitution position is related to the localization effect of the substituent on the ring.
Fourth, reduction reaction. The ester group in the molecule can be reduced by a specific reducing agent. In the case of a strong reducing agent, lithium aluminum hydride, the ester group can be reduced to an alcohol, that is, 2-methylthiophene-3-methanol. Lithium aluminum hydride provides hydrogen negative ions and attacks the ester carbonyl carbon. After a complex process, the ester group is converted into an alcohol hydroxyl group.

I don't know what the market price of "Methyl 2 - methylthiophene - 3 - carboxylate" is. This is a more professional chemical substance, and its price fluctuates or is affected by many factors.
First, the difficulty of production has a great impact. If the preparation requires complex processes, special raw materials or harsh reaction conditions, the cost will be high, and the price will also rise.
Second, the market supply and demand relationship is also critical. If demand is strong and supply is limited, merchants may raise prices because of it; conversely, when supply exceeds demand, the price may decrease.
Third, purity is also an important factor in determining price. The price of this substance with high purity is often much higher than that of low purity due to the high cost of separation and purification.
Fourth, the price varies depending on the source. The price of imported products or due to customs duties, transportation and other costs is different from that of domestic products.
Because I have not found the exact price information, it is difficult to give an accurate quotation. If you want to know the details, you can consult chemical product suppliers, relevant chemical trading platforms, or search on professional chemical reagent sales websites to get more accurate prices.