methyl 2-amino-4-(4-chlorophenyl)thiophene-3-carboxylate

Methyl 2-amino-4- (4-chlorophenyl) thiophene-3-carboxylic acid ester, which has a wide range of uses. In the field of medicine, it is a key intermediate for the synthesis of specific drugs. The unique chemical properties of the structure of geinthiophene and chlorophenyl can give the prepared drugs specific physiological activities, such as antibacterial, anti-inflammatory or anti-tumor effects. For example, it may act on specific metabolic pathways of bacteria, interfere with their growth and reproduction, and achieve antibacterial purposes; in the inflammatory response, regulate relevant signaling pathways and reduce inflammatory symptoms.
In the field of materials science, methyl 2-amino-4- (4-chlorophenyl) thiophene-3-carboxylate also has potential applications. Because its molecular structure contains a variety of active groups, it can be chemically modified to connect to the main chain or side chain of polymer materials to improve the properties of materials. For example, to enhance the stability of materials and improve their optical properties, materials can be used in optical devices, such as Light Emitting Diodes, sensors, etc., to achieve sensitive detection of specific substances or physical quantities by interacting with the external environment through specific structures.
In addition, in the field of organic synthetic chemistry, as an important synthetic building block, with its multi-activity check point characteristics, it can participate in a variety of organic reactions, build more complex organic molecular structures, provide rich raw materials and synthetic paths for the development of organic synthetic chemistry, help scientists explore new organic compounds, and expand the research boundaries of organic chemistry.

To prepare methyl 2-amino-4- (4-chlorophenyl) thiophene-3-carboxylic acid ester, there are many methods, which can be selected as described below.
First, the thiophene derivative containing the corresponding substituent can be started. First, a suitable thiophene raw material is taken, and after halogenation, a halogen atom is introduced at a specific position in the thiophene ring. This halogen atom will play a key role in the reaction later, or act as a leaving group in the nucleophilic substitution reaction. Then react with an amino-containing reagent to complete the introduction of the amino group. Next, through a suitable carboxylic acid esterification reaction, the carboxyl group of the thiophene ring and methanol are esterified under heating conditions in the presence of suitable catalysts such as concentrated sulfuric acid or p-toluenesulfonic acid, thereby forming the ester group moiety of the target product.
Second, you can also start from the construction of the thiophene ring. A compound containing 4-chlorophenyl group and a reagent containing sulfur and other necessary functional groups are cyclized to form a thiophene ring structure. In this process, the reaction conditions and the proportion of reactants can be cleverly designed, so that the cyclization is easy to introduce amino and carboxyl groups at the same time or later, and then the carboxyl group is esterified with methanol. For example, some multi-step reaction tandem strategies use the activity difference and reaction sequence between reactants to gradually build the structure of each part of the target molecule in the same reaction system, reducing the cumbersome steps of intermediate product separation and improving the reaction efficiency.
Third, the mature methods reported in the literature can also be used for reference and optimized according to the actual situation. There are many synthetic pathways similar to thiophene-containing compounds in the literature on organic synthesis. Reference can be made to relevant reaction conditions, reagent selection and post-treatment methods, combined with the specific structural characteristics of the target product, and careful adjustment of temperature, solvent, catalyst and other factors to achieve better synthesis. The effect is to obtain high-purity methyl 2-amino-4- (4-chlorophenyl) thiophene-3-carboxylate.

Methyl 2-amino-4- (4-chlorophenyl) thiophene-3-carboxylic acid ester, this is an organic compound. In terms of physical and chemical properties, it has specific properties, melting point, boiling point, solubility and stability.
Looking at its properties, under normal temperature and pressure, it may be solid, and its appearance may be white to light yellow powder or crystalline. Because of this class of compounds containing thiophene and chlorophenyl, many have such appearance characteristics.
In terms of melting point, due to the presence of amino groups, ester groups and chlorophenyl groups in the molecule, interactions such as hydrogen bonds and van der Waals forces are formed with each other, resulting in relatively high melting points. However, the specific value, because the accurate determination requires professional experiments, is speculated according to similar structural compounds, or is in the range of 150-200 ℃.
The boiling point is also affected by the groups in the molecular structure, the intermolecular force is enhanced, and the boiling point is higher. Unmeasured, according to similar structures, it is estimated to be around 350-450 ℃.
In terms of solubility, because it is an organic ester compound, it contains hydrophobic phenyl and thiophenyl groups, and has little solubility in polar solvents such as water. In common organic solvents such as dichloromethane, chloroform, tetrahydrofuran, toluene, etc., the solubility is relatively good. This is based on the principle of similarity compatibility. The hydrophobic structure of the compound is compatible with the non-polar or weak polar of organic solvents.
In terms of stability, under normal storage conditions, it is relatively stable in a dry, cool and dark place. When encountering strong acids and bases, ester groups are easy to hydrolyze, and amino groups may also participate in acid-base reactions; when encountering strong oxidants, thiophene rings containing sulfur may be oxidized, resulting in structural changes. When the light is too strong, the conjugated structure in the molecule or luminescent chemical reactions affect its stability.

What you are asking is the market price of "methyl 2 - amino - 4 - (4 - chlorophenyl) thiophene - 3 - carboxylate". This is a chemical substance. In the era of "Tiangong Kaiwu", there was no such fine chemical substance, and there was no market price to consider. However, today is different from the past, the chemical industry is prosperous, and the price of this substance varies for many reasons.
Its price is often affected by the cost of raw materials. If the raw materials for preparing this compound are difficult to obtain, or the price of raw materials rises, the cost of this substance will increase, and the price will also increase. Furthermore, the difficulty of the synthesis process also has an impact. If the synthesis step is cumbersome and special equipment and technology are required, the production cost will be high and the market price will not be low.
And the market supply and demand relationship is the key. If the demand is strong and the supply is limited, the merchant may raise the price to make more profits; on the contrary, if the supply exceeds the demand, the merchant may reduce the price for promotion. In addition, the reputation and product quality of the manufacturer can also make the price different. Manufacturers with good reputation and excellent quality may have slightly higher product prices.
I am sorry, I do not know the specific market conditions, and it is difficult to determine the price. If you want to know the details, you can consult the chemical reagent supplier, or look for it on the chemical product trading platform, and you will get relatively accurate price information.

Methyl 2-amino-4- (4-chlorophenyl) thiophene-3-carboxylic acid ester, this is a fine chemical compound. Its storage conditions are crucial to the quality and effectiveness of this compound.
According to ancient archives, the storage of this kind of chemical substance depends on the temperature and humidity of the first environment. It should be placed in a cool place away from direct sunlight, because light and high temperature can cause chemical changes and damage its quality. The temperature should be controlled between 15 and 25 degrees Celsius, and this temperature range can ensure its chemical stability. If the temperature is too high, the molecular activity will be enhanced, or adverse reactions such as decomposition and polymerization will be triggered; if the temperature is too low, it may cause crystallization and solidification, which will affect the use and performance.
Furthermore, the humidity should also be paid attention to. The environment should be dry, and the humidity should be 40% to 60%. If the humidity is too high, this substance may absorb moisture, causing its purity to decrease, or even triggering reactions such as hydrolysis, destroying its chemical structure.
In addition to temperature and humidity, the storage should also be clean and avoid mixing with other chemicals. It must be kept away because it may react chemically with different substances, especially those with strong oxidizing or reducing properties. It should be stored separately in a special storage cabinet or warehouse and marked for easy access and management.
In addition, storage containers are also well-crafted. Glass or corrosion-resistant plastic materials should be used because of their stable chemical properties, which are not easy to react with the stored material, ensuring that the quality of the material remains unchanged for a long time.