What are the physical properties of ethyl 5-chlorothiophene-2-carboxylate?

7-Carboxyacetoxycoumarin, an organic compound, has the following physical properties:

Looking at its morphology, it often takes the shape of a white to light yellow crystalline powder, which makes it easy to handle and apply in many chemical and pharmaceutical fields.

When it comes to solubility, 7-carboxyacetoxycoumarin is slightly soluble in water. Water is a common solvent, and its slightly soluble properties indicate that the compound is poorly hydrophilic. However, it is soluble in some organic solvents, such as ethanol, dichloromethane, etc. In ethanol, 7-carboxyacetoxycoumarin can be dispersed by virtue of the polarity of ethanol and specific intermolecular forces; dichloromethane, as a non-polar organic solvent, can also provide a dissolution environment for 7-carboxyacetoxycoumarin, which gives it the possibility to participate in reactions or separate and purify in different solvent systems.

When it comes to the melting point, the melting point of this compound is in a specific range, about 195-199 ° C. As an important physical constant of a substance, the melting point reflects the strength of intermolecular forces. 7-carboxyacetoxycoumarin transitions from solid to liquid in this temperature range, which is of great significance for identification and purity detection. The melting point of the compound with high purity should be close to the theoretical value. If it contains impurities, the melting point may decrease and the melting range may become wider.

Its stability is also an important physical property. Under normal storage conditions, 7-carboxyacetoxycoumarin is relatively stable. When exposed to light, heat or a specific chemical environment, its stability may be affected. For example, under light, intra-molecular electrons excite, or cause reactions such as chemical bond breaking and rearrangement; high temperature environment may also promote decomposition or other chemical changes. Therefore, it should be stored in a cool, dry and dark place to maintain the stability of its chemical structure and properties.

What are the chemical properties of ethyl 5-chlorothiophene-2-carboxylate?

The chemical properties of 5-alkoxy-2-carboxylethyl ester are as follows:

This compound has the characteristics of an ester. Esters can undergo hydrolysis in an acid or alkali environment. In an acidic medium, the hydrolysis process is relatively slow, and after an equilibrium reaction, carboxylic acids and alcohols are formed. For example, under the condition of dilute sulfuric acid and heating, 5-alkoxy-2-carboxylethyl esters are slowly hydrolyzed to obtain corresponding products such as 5-alkoxy-2-carboxylic acids and ethanol. In a basic environment, the hydrolysis reaction is more rapid and thorough. Take sodium hydroxide solution as an example, this compound hydrolyzes rapidly to form carboxylic salts and alcohols. This process is irreversible because carboxylic salts are more stable than carboxylic acids.

The carboxyl group in its molecule also has unique properties. The carboxylic group is acidic and can be neutralized with bases. When encountering sodium hydroxide, the hydrogen atom in the carboxylic group dissociates and combines with hydroxide ions to form water, and the carboxylic group converts into a carboxylic negative ion to form the corresponding carboxylate sodium salt. In addition, the carboxylic group can participate in the esterification reaction. If it is catalyzed by concentrated sulfuric acid and heated with alcohols, an esterification reaction can occur to generate new esters and water.

Furthermore, although the alkoxy group in the molecule is relatively stable, under certain conditions, substitution reactions may occur when encountering strong nucleophiles. Nucleophiles can attack the carbon atoms attached to the alkoxy group and replace the alkoxy group to form new compounds.

5-alkoxy-2-carboxylethyl esters have important applications and reactivity in many fields such as organic synthesis due to their functional group properties.

What is the common synthesis method of ethyl 5-chlorothiophene-2-carboxylate?

The common synthesis method of 5-cyanopentanoic acid-2-carboxylethyl ester is obtained through a multi-step reaction.

The first step is to start from common raw materials, such as selecting suitable halogenated hydrocarbons and cyanides, and introducing cyanyl groups through nucleophilic substitution. This step needs to be carried out under suitable solvent and temperature conditions to ensure the smooth occurrence of the reaction. For example, halopentane and sodium cyanide are mixed in polar solvents. Under appropriate heating conditions, halogen atoms are replaced by cyanyl groups to form cyanopentanes.

The next step is to carboxylate the generated cyanopentane. Specific reagents and reaction conditions can be used to convert cyanyl groups into carboxyl groups. For example, under acidic or basic hydrolysis conditions, the cyanyl group is hydrolyzed to form a carboxyl group, resulting in a valeric acid derivative.

The third step is to prepare a 2-carboxyethyl ester moiety. Usually ethanol is selected with the corresponding carboxylic acid or its derivatives, and under the action of a catalyst, it is achieved by esterification. Concentrated sulfuric acid is used as a catalyst to make the carboxylic acid and ethanol co-heat, and an esterification reaction occurs to form an ester group structure.

The last step is to connect the carboxyvaleric acid derivative with the prepared 2-carboxyethyl ester moiety through suitable reaction conditions. Or by means of condensation reaction, in a suitable catalyst and reaction environment, the two are connected to finally obtain 5-cyanovaleric acid-2-carboxyethyl ester. The whole synthesis process requires precise control of reaction conditions, such as temperature, reagent dosage, reaction time, etc., to improve the yield and purity of the product.

In which fields is ethyl 5-chlorothiophene-2-carboxylate used?

Ethyl 5-alkylhydrazine-2-carboxylate is used in many fields. In the field of medicine, this compound has shown unique efficacy. Physicians use its special chemical structure to develop drugs for the treatment of a variety of diseases. For example, in the creation of some anti-inflammatory drugs, ethyl 5-alkylhydrazine-2-carboxylate can be used as a key intermediate to participate in the construction of drug active ingredients, helping to relieve human inflammation and relieve patients' pain.

In the field of materials science, it also plays an important role. Materials scientists have found that incorporating an appropriate amount of this substance into a specific material system can significantly improve material properties. For example, the addition of certain polymer materials can enhance the stability and flexibility of the material, so that the products such as plastic products, fiber fabrics, etc., have better quality and longer service life, and are widely used in industrial production and daily necessities manufacturing.

In the agricultural field, 5-alkylhydrazine-2-carboxylate ethyl ester is also promising. Agricultural researchers explore its potential in pesticide research and development, hoping to use it to develop high-efficiency, low-toxicity and environmentally friendly new pesticides. Such pesticides can precisely act on crop diseases and pests, effectively inhibit the growth and reproduction of pests and the spread of pathogens, ensure the healthy growth of crops, improve the yield and quality of agricultural products, and provide strong support for sustainable agricultural development.

What is the market price of ethyl 5-chlorothiophene-2-carboxylate?

Today, the market price of 5-bromouracil-2-carboxyethyl ester is volatile, and it is difficult to determine the market price of 5-bromouracil-2-carboxyethyl ester.

The supply and demand of Fu City is the main reason. If this product is widely needed in various industries, such as pharmaceutical research and biochemical experiments, the demand is large and the supply is limited, the price will increase. On the contrary, if there is a lack of demand, and the excess production, the price will naturally decrease.

Furthermore, its manufacturing cost also affects the price. The price of raw materials and the simplicity of the process are all related to it. If the raw materials are rare, difficult to harvest, costly, or the manufacturing method is complicated, and the use of ingenious tools or ingenious techniques is required, the cost will increase and the price will rise accordingly.

And the competition in the market cannot be ignored. If there are many people who produce this product and compete for the market, each wants to be attractive at a price, and the price may drop because of it. If there are few people who have property, it is almost monopolistic, and the price is easy to be controlled by them.

The regulations of the government and the changes in the current situation also affect it. If the government sets up a tax system, or strictly regulates production, it can increase or decrease the cost, which will cause the price to fluctuate. The current situation is turbulent, traffic is blocked, and logistics is not smooth, which can also make the price different from usual.

Therefore, if you want to know the market price of 5-bromouracil-2-carboxyethyl ester, you can get a rough idea when considering the situation and looking at supply and demand, costs, competition, and government orders. However, it is difficult to determine the exact price.