What is the chemical structure of ethyl-2- [ (ethoxycarbonyl) amino] -4-methyl-5- (4-nitrophenyl) thiophene-3-carboxylate

Alas! This is the name of an organic compound. To know its chemical structure, you need to analyze its name in detail. "Ethyl - 2 - [ (ethoxycarbonyl) amino] - 4 - methyl - 5 - (4 - nitrophenyl) thiophene - 3 - carboxylate". Looking at this name, "ethyl" is the first, which means ethyl. It can be seen that this compound contains ethyl groups. "2 - [ (ethoxycarbonyl) amino]" means that there is a group connected by ethoxycarbonyl and amino at the second position of the main chain, ethoxycarbonyl is -COOCH < unk > CH, the amino group is -NH < unk >, and the two are connected to form -NHCOOCH < unk > CH < unk >. " 4 - methyl "indicates that the 4th position has methyl-CH
." 5 - (4 - nitrophenyl) "The 5th position of the table is connected with p-nitrophenyl group, and the p-nitrophenyl group, that is, the para-position of the benzene ring, has nitro-NO ³." Thiophene "is a thiophene ring, which is the core structure of the compound." 3 - carboxylate "means that the 3rd position has a carboxylic acid ester group.

Overall, this compound is centered on a thiophene ring, connected to -NHCOOCH -2 CH at the 2nd position, to a carboxylic acid ester group at the 3rd position, to methyl-CH at the 4th position, and to a p-nitrophenyl group at the 5th position. In this way, its chemical structure is clear. Although the name is long and complicated, according to the naming rules of organic chemistry, its structure can be resolved step by step.

What are the main uses of ethyl-2- [ (ethoxycarbonyl) amino] -4-methyl-5- (4-nitrophenyl) thiophene-3-carboxylate

Ethyl - 2 - [ (ethoxycarbonyl) amino] - 4 - methyl - 5 - (4 - nitrophenyl) thiophene - 3 - carboxylate is an organic compound. Its main uses are quite extensive, and it is often used as a key intermediate in the field of organic synthesis, assisting in the construction of more complex organic molecular structures. This compound contains special functional groups. Through specific chemical reactions, it can realize functional group transformation and molecular skeleton expansion, laying the foundation for the synthesis of compounds with specific biological activities or material properties.

In the field of pharmaceutical chemistry, or because of its structural properties, it exhibits certain biological activities, or can participate in the process of drug development. Some parts of its structure may interact with specific targets in vivo, providing an opportunity for the development of new drugs, or for the optimization of lead compounds to improve drug efficacy and reduce toxic and side effects.

In the field of materials science, this compound may be suitable for the preparation of functional materials due to its unique electronic structure and chemical properties. For example, with its conjugated structure and nitro and other groups, it may be able to make a difference in photoelectric materials, used in the manufacture of organic Light Emitting Diodes, solar cells and other devices, endowing materials with specific electrical and optical properties.

What is the synthesis method of ethyl-2- [ (ethoxycarbonyl) amino] -4-methyl-5- (4-nitrophenyl) thiophene-3-carboxylate

To prepare ethyl - 2 - [ (ethoxycarbonyl) amino] -4 - methyl - 5 - (4 - nitrophenyl) thiophene - 3 - carboxylate, the following ancient method can be used.

First take a suitable reaction vessel and wipe it with a clean cloth to ensure that there are no impurities. Prepare 4 - methyl - 5 - (4 - nitrophenyl) - 2 - aminothiophene - 3 - carboxylic acid and place it in the container. It can be prepared from suitable starting materials through multi-step reaction, and the conditions of each step need to be carefully controlled to ensure that the yield and purity meet the requirements. < Br >
Take an appropriate amount of ethyl chloroformate and slowly drop it into a container containing the above compound. This process needs to be carried out at low temperature and stirred, such as in an ice bath, and stirred at a constant speed with a magnetic stirrer, so that the two can be fully mixed. Due to the high activity of ethyl chloroformate, the speed of dropwise addition should not be too fast, so as not to overreact.

Prepare an appropriate amount of alkali, such as triethylamine, and slowly add it to the reaction system. The function of alkali is to promote the progress of the reaction, so that the amino group and ethyl chloroformate can be condensed smoothly. When adding alkali, it is also necessary to pay attention to the change of temperature and adjust it in a timely manner to prevent the temperature from rising sharply. < Br >
During the reaction, observe the reaction process by thin layer chromatography (TLC). When the raw material point gradually fades and the product point is clear and no longer changes, the reaction is nearly complete.

After the reaction is completed, pour the reaction solution into an appropriate amount of water and extract the product with an organic solvent. Commonly used organic solvents such as ethyl acetate are extracted several times and combined with the organic phases.

After drying the organic phase with anhydrous sodium sulfate, let it stand for a while to remove the water. After that, the organic solvent is evaporated under reduced pressure with a rotary evaporator to obtain a crude product.

The crude product needs to be purified by column chromatography. Select a suitable silica gel column and elute with a suitable eluent, such as a mixture of petroleum ether and ethyl acetate, and gradually change in proportion to separate the product from impurities. Collect the eluent containing pure product, steam off the solvent, and finally obtain ethyl - 2 - [ (ethoxycarbonyl) amino] -4 - methyl - 5 - (4 - nitrophenyl) thiophene - 3 - carboxylate, weigh and measure its purity to ensure that it meets the required standards for the experiment. The whole process requires the experimenter to be meticulous and precisely control the conditions of each step to successfully obtain the target product.

What are the physical properties of ethyl-2- [ (ethoxycarbonyl) amino] -4-methyl-5- (4-nitrophenyl) thiophene-3-carboxylate

Ethyl - 2 - [ (ethoxycarbonyl) amino] - 4 - methyl - 5 - (4 - nitrophenyl) thiophene - 3 - carboxylate, this is an organic compound. Looking at its physical properties, the compound may have a specific melting point and boiling point. The melting point is the temperature at which the substance changes from solid to liquid. The melting point of this compound is affected by factors such as intermolecular forces and crystal structures. The intermolecular forces are strong, but the melting point is high; the crystal structure is regular, which also helps to improve the melting point.

In terms of boiling point, it is the temperature at which a substance changes from liquid to gaseous under a specific pressure. It is affected by molecular mass, intermolecular forces, etc. In general, the molecular weight is large and the boiling point is high; the intermolecular force is strong and the boiling point is also high.

In terms of solubility, the compound may exhibit different solubility characteristics in organic solvents. Organic solvents such as ethanol, ether, dichloromethane, etc. have different interactions with the compound molecules, which affect their solubility. If the compound and the solvent molecules can form hydrogen bonds, van der Waals forces, etc., or are more soluble.

In addition, the density of the compound is also one of its physical properties. The density is restricted by the molecular weight and the way of molecular packing. The molecular mass is large and the packing is tight, but the density is large.

Appearance is either a specific color and shape, or a solid crystal, or a powder, which is also determined by its molecular structure and crystal formation process. The conditions of crystal formation, such as temperature, solvent, etc., all affect the appearance.

From the above, it can be seen that the physical properties of ethyl - 2 - [ (ethoxycarbonyl) amino] - 4 - methyl - 5 - (4 - nitrophenyl) thiophene - 3 - carboxylate are affected by various factors such as molecular structure, intermolecular forces and external conditions.

What are the chemical properties of ethyl-2- [ (ethoxycarbonyl) amino] -4-methyl-5- (4-nitrophenyl) thiophene-3-carboxylate

Ethyl - 2 - [ (ethoxycarbonyl) amino] - 4 - methyl - 5 - (4 - nitrophenyl) thiophene - 3 - carboxylate is an organic compound with a specific chemical structure and properties. It is composed of complex atomic combinations and contains thiophene rings, which are connected with various substituents, such as ethoxycarbonyl amino, methyl, p-nitrophenyl and ethyl ester groups.

From the perspective of physical properties, such compounds containing nitro and ester groups have different intermolecular forces due to the strong electron absorption of nitro groups and the existence of ester groups, or have specific melting points and boiling points. In view of the presence of many polar groups in its structure, it may have some solubility in organic solvents, but the specific solubility depends on factors such as solvent type and temperature.

In terms of chemical properties, the reactivity of the compound is determined by the functional groups it contains. The amino group in the ethoxycarbonyl amino group has certain nucleophilic properties and can participate in nucleophilic substitution reactions, such as reacting with halogenated hydrocarbons to form new amine compounds. Esteryl groups can undergo hydrolysis under the catalysis of acids or bases, hydrolysis into carboxylic acids and alcohols under acidic conditions, and carboxylate and alcohols under basic conditions. Although the thiophene ring is relatively stable, under certain conditions, electrophilic substitution reactions can also occur. Due to the high density of π electron clouds, the presence of p-nitrophenyl groups will affect the electron cloud distribution on the thiophene ring, changing the reactivity and regioselectivity. In addition, nitro groups can be reduced to amino groups, opening new reaction paths and synthesizing more functionalized derivatives.