Ethyl 2-aminothiophene-3-carboxylate

Ethyl 2-aminothiophene-3-carboxylate (ethyl 2-aminothiophene-3-carboxylate) is widely used in various fields of chemical industry.
In the field of organic synthesis, it often acts as a key intermediate. Because of its unique molecular structure, thiophene ring coexists with amino group and ester group, and this structure gives it special reactivity. For example, through specific chemical reactions, its amino group or ester group can be modified to prepare various organic compounds with special functions. Or when building complex organic molecular structures, with its activity check point, it participates in cyclization, chain formation and other reactions, laying the foundation for the synthesis of novel organic materials.
In medicinal chemistry, it is also highly valued. Its structure can be modified to meet the needs of specific biological targets. Chemically modified derivatives may have potential biological activities, such as antibacterial, anti-inflammatory, anti-tumor and other effects. Researchers often use it as a starting material to explore and develop new drugs with higher efficacy and lower toxicity and side effects through multi-step reactions.
In the field of materials science, it is also useful. By copolymerizing with other monomers or modifying the surface of materials, materials with special properties can be prepared. For example, improving the electrical, optical or mechanical properties of materials provides the possibility for the development of new functional materials. < Br >
In the manufacture of fine chemicals, it can be used to synthesize various fine chemicals, such as special fragrances, pigments, etc. Its unique structure imparts special properties to the product, enhancing the quality and performance of fine chemicals.

Ethyl 2-aminothiophene-3-carboxylate is an organic compound, and there are many methods for synthesis. One common one is to use 2-cyanothiophene-3-carboxylate ethyl ester as the starting material and obtain it by reduction reaction. In the reactor, add 2-cyanothiophene-3-carboxylate ethyl ester, dissolve in a suitable solvent, such as ethanol, methanol and other alcoholic solvents, and then add reducing agents, such as lithium aluminum hydride, sodium borohydride, etc. Control the reaction temperature and time. If lithium aluminum hydride is used, the temperature may need to be at a low temperature, such as 0 ° C to -10 ° C, and the reaction takes several hours. After the reaction is completed, after post-treatment, such as quenching excess reducing agent with water, separating liquid, washing, drying the organic phase, and removing the solvent by rotary evaporation, the crude product can be obtained, and then purified by means of column chromatography to obtain pure Ethyl 2-aminothiophene-3-carboxylate.
Another method is to use 2-nitrothiophene-3-carboxylate as raw material and reduce it. 2-nitrothiophene-3-carboxylate ethyl ester is placed in a reaction vessel, and a suitable solvent is selected, such as ethyl acetate mixed with ethanol. Metal reducing agents such as iron powder and zinc powder are added, or hydrogen is introduced, and palladium carbon is used as a catalyst. If reduced with hydrogen, react at a certain pressure, such as 1-3 atm, at room temperature to 50 ° C. The reaction is completed, the catalyst or metal reduction product is filtered off, the filtrate is concentrated, and the post-treatment is the same as the previous method to obtain the target product.
In addition, the carboxyl group and amino group can be introduced first from thiophene. Taking thiophene as the starting material, the carboxyl group is introduced through the Friedel-Crafts reaction to form thiophene-3-carboxylic acid. With a suitable reagent, such as sulfoxide chloride, it is converted into an acyl chloride, which is then reacted with ethanol to form ethyl ester. After nitrification, the nitro group is introduced at the 2nd position, and then the 2-amino group is reduced. After each step of the reaction, it is necessary to properly handle and select the appropriate purification method according to the characteristics of the reaction to obtain high purity Ethyl 2-aminothiophene-3-carboxylate.

Ethyl 2-aminothiophene-3-carboxylate is an organic compound with specific physical properties. Its properties are usually solid or liquid, but the exact state varies according to environmental conditions.
Looking at its melting point, this value is very important in identification and purity determination. The melting point of the compound is different at different purity. Those with high purity have a narrow melting point range and approach the theoretical value. Otherwise, the melting point decreases and the range becomes wider.
The boiling point is also an important property. The boiling point reflects the energy required for the compound to change from liquid to gaseous state, which helps to understand its volatility and stability under different temperature environments. It is of great significance for separation and purification processes such as distillation.
In terms of solubility, Ethyl 2-aminothiophene-3-carboxylate has good solubility in organic solvents such as ethanol, ether, and chloroform. Due to the principle of similar miscibility, its organic structure interacts well with organic solvents; its solubility in water may be limited due to the large proportion of hydrophobic organic groups.
The density is related to the relationship between the mass and volume of the compound, and it is of great significance for the calculation of the proportion of materials involved in solution preparation and reaction. Accurate density data can ensure accurate delivery of materials in experiments and production, which in turn affects the reaction process and product quality.
Ethyl 2-aminothiophene-3-carboxylate refractive index is also one of the characteristics. Refractive index refers to the degree of change in the propagation direction of light from a medium into the compound. The specific refractive index can be used as a basis for identification, and is indispensable for studying the relationship between its optical properties and molecular structure.
Ethyl 2-aminothiophene-3-carboxylate These physical properties are interrelated and affect their application. Understanding and mastering them is helpful for rational application in organic synthesis, drug development and other fields.

Ethyl 2-aminothiophene-3-carboxylate is an organic compound with many unique chemical properties.
It contains functional groups such as amino and ester groups, so it has the characteristics of two types of functional groups. The amino group is basic and can react with acids to form salts. In the case of inorganic acids such as hydrochloric acid, amino nitrogen atoms will bind protons to form corresponding ammonium salts. This reaction is often used in organic synthesis to improve the water solubility of compounds, which is conducive to subsequent separation and purification.
The ester group is active and can undergo hydrolysis reactions. Under acidic conditions, the hydrolysis produces 2-aminothiophene-3-carboxylic acid and ethanol, and the reaction is reversible; under alkaline conditions, the hydrolysis is more thorough, resulting in carboxylic salts and ethanol, which are often used in organic synthesis to prepare carboxylic acid compounds.
At the same time, this compound has certain stability and special optical properties due to its conjugate system. The conjugate system delocalizes electrons and reduces molecular energy. There are specific absorption peaks in the ultraviolet-visible spectrum, which can be used for qualitative and quantitative analysis.
In addition, Ethyl 2-aminothiophene-3-carboxylate can participate in many organic reactions as a key intermediate. For example, nucleophilic substitution reactions with halogenated hydrocarbons can replace alkoxy groups in amino or ester groups to generate derivatives with diverse structures, laying the foundation for the synthesis of complex organic compounds, which are widely used in the fields of medicinal chemistry and materials science.

Wuweiwen has confirmed the price of ethyl-2-aminothiophene-3-carboxylate in the market. However, if you want to know its price, you can take a variety of ways. First, visit chemical companies, this generation often sells various chemicals, or you can tell you the price of this thing. Second, log on to chemical e-commerce platforms, such as Mobell, etc. Such platforms gather information on chemical products, or you can find their prices. Third, ask chemical raw material suppliers, who specialize in chemical trading, and state their prices.
However, its price often changes due to a variety of reasons. Its purity is a major factor. If the purity is high, the price may be expensive; otherwise, the price may be cheap. The quantity also has an impact. If the purchase volume is large, the merchant may give a discount; if the purchase volume is small, the price may not be favorable. Furthermore, the supply and demand of the market is also related to the price. If you need more supply and less supply, the price may go up; if you need less supply and more, the price may go down. And the origin, transportation costs, etc., can all be different. If you want to know the exact price, you must consult the relevant merchants in person and observe the market situation carefully.