ethyl 2-amino-5-methylthiophene-3-carboxylate

Ethyl 2 - amino - 5 - methylthiophene - 3 - carboxylate is an organic compound with unique chemical properties. In its structure, the thiophene ring is the core, and the carboxyl ethyl ester is at a specific position with amino and methyl thiophenyl groups. This structure endows it with various chemical activities.
From the perspective of acidity and alkalinity, amino groups are weakly basic and can react with acids to form corresponding salts. For example, in the case of hydrochloric acid, amino nitrogen atoms will bind hydrogen ions to form positively charged ions, achieving acid-base neutralization.
In terms of nucleophilicity and electrophilicity, amino groups are nucleophilic check points because nitrogen atoms have lone pairs of electrons and can attack electrophilic reagents. If under suitable reaction conditions, it can undergo nucleophilic substitution with halogenated hydrocarbons. The nitrogen atom attacks the carbon atom connected to the halogen in the halogenated hydrocarbons, and the halogen leaves to form a new carbon-nitrogen bond compound.
The carboxyl ethyl ester part is electrophilic, especially the carbonyl carbon is partially positively charged due to the strong electron-absorbing action of the oxygen atom, and is easily attacked by nucleophilic reagents. Like alcohol nucleophilic reagents, under the action of a specific catalyst, they can undergo ester exchange reaction with carboxyl ethyl esters. The oxygen atom of the alcohol attacks the carbonyl carbon, and the ethoxy group leaves to form a new ester.
In addition, although the thiophene ring is relatively stable, it can also react under certain conditions. If under appropriate catalyst and reaction conditions, aromatic ring substitution reaction can be carried out, and other functional groups can be introduced to expand its chemical properties and uses.
This compound is widely used in the field of organic synthesis due to these chemical properties, and can be used as an intermediate for the preparation of various organic compounds such as drugs and materials.

To prepare ethyl-2-amino-5-methylthiophene-3-carboxylate, the following method can be followed.
First take 2-amino-5-methylthiophene-3-carboxylic acid as the starting material. In a suitable reaction vessel, add an appropriate amount of the carboxylic acid, and add an appropriate amount of anhydrous ethanol as a solvent. This anhydrous ethanol is not only the reaction medium, but also participates in the reaction. Then, slowly add an appropriate amount of concentrated sulfuric acid. Concentrated sulfuric acid is used here as a catalyst to accelerate the reaction. The dropwise addition process needs to be slow and stirred at the same time to make the material mix evenly and avoid undesirable conditions such as local overheating. < Br >
The reaction system is heated to a suitable temperature, which usually needs to be carefully explored according to the specific conditions of the experiment, generally between 60 and 80 ° C. The reaction is continued at this temperature for several hours to make the reaction sufficient. During the reaction, the reaction process needs to be closely monitored, and the ratio of raw materials to products can be detected by means of thin layer chromatography (TLC) to clarify the reaction progress.
After the reaction is completed, the reaction solution is cooled to room temperature. After that, pour the reaction solution into an appropriate amount of ice water, and carefully adjust the pH to neutral or slightly alkaline with sodium hydroxide solution or sodium carbonate solution. The purpose of this operation is to stabilize the product in the form of salt and remove excess acid. After that, it is extracted with an organic solvent such as ethyl acetate. After multiple extractions, the organic phases are combined.
Then the organic phase is dried with a desiccant such as anhydrous sodium sulfate to remove moisture. Then, the organic solvent is removed by reduced pressure distillation to obtain a crude product. Finally, the crude product is purified by column chromatography or recrystallization, and a suitable eluent or solvent is selected to obtain a pure ethyl-2-amino-5-methylthiophene-3-carboxylate. In this way, the preparation of this compound is completed.

Ethyl 2-amino-5-methylthiophene-3-carboxylate is an organic compound with a wide range of main uses.
In the field of medicinal chemistry, it is often a key intermediate. Due to the structure of this compound, it is endowed with unique chemical activity and reaction characteristics. Through specific chemical reactions, its structure can be modified and modified to synthesize many drug molecules with specific pharmacological activities. For example, in the development of some innovative drugs for the treatment of specific diseases, ethyl 2-amino-5-methylthiophene-3-carboxylate is used as a starting material to build a complex drug molecular structure through multi-step reactions, which has made great contributions to human health. < Br >
In the field of materials science, it also has important uses. Due to its special chemical structure, it can participate in specific polymerization reactions to form polymer materials with special properties. Such materials may have excellent electrical properties, optical properties or thermal stability, etc., and have potential applications in many high-tech fields such as electronic devices and optical instruments. For example, specific functional layer materials used in the preparation of organic Light Emitting Diodes (OLEDs) can improve the luminous efficiency and stability of devices.
In addition, in organic synthetic chemistry, ethyl 2-amino-5-methylthiophene-3-carboxylate is a common synthetic building block, providing a basis for the construction of more complex organic molecules. Chemists can use its activity check point to introduce different functional groups through various classical organic reactions, such as nucleophilic substitution reactions, coupling reactions, etc., to expand the diversity of molecular structures, thereby synthesizing a wide variety of organic compounds, greatly enriching the organic compound library, providing many options for chemical research and industrial production.

The exact price range of "ethyl 2-amino-5-methylthiophene-3-carboxylate" has not been obtained. This compound is a commonly used intermediate in organic synthesis, and its price is affected by many factors.
First, the purity has a great impact. For high purity, the preparation process is difficult, the cost is also high, and the price must be expensive; for low purity, the preparation is easier and the price should be low. If the purity reaches more than 99%, the price may be several times higher than that of 95% purity.
Second, the market supply and demand relationship is the key. If many pharmaceutical companies and chemical companies compete for the purchase, the demand is strong, but the supply is limited, the price will rise; on the contrary, if the demand is weak and the supply is sufficient, the price may decline.
Third, the preparation cost also plays a role. The price of raw materials, the number of synthesis steps, energy consumption, etc., are all related to the cost. Raw materials are scarce and expensive, or the synthesis steps are lengthy and complicated, and the cost will be high, resulting in an increase in product prices.
Fourth, manufacturers are related to the number of transactions. Different manufacturers have different pricing. Large manufacturers have controllable costs or price advantages due to scale effects. And if the purchase volume is large, manufacturers may give discounts and reduce the unit price.
To know the exact price range, you can consult chemical raw material suppliers, chemical reagent sales platforms, or inquire from industry insiders at industry exhibitions and forums to obtain a close price.

Ethyl + 2 - amino - 5 - methylthiophene - 3 - carboxylate is an organic compound, the Chinese name or 2 - amino - 5 - methylthiophene - 3 - carboxylate ethyl ester. During storage and transportation, the following things should be paid attention to:
First, the storage temperature is very important. This substance should be stored in a cool place. Due to high temperature, it is easy to cause its chemical properties to change, or to cause reactions such as decomposition, which will damage its quality and stability. Therefore, the warehouse temperature should be properly regulated and not too high to ensure its stability.
Second, moisture resistance should not be ignored. If the compound encounters water vapor or undergoes reactions such as hydrolysis, its purity and performance will be affected. The storage environment must be dry. A desiccant can be placed in the storage container to absorb water vapor, and the storage place should be free of water leakage.
Third, the packaging must be sturdy during transportation. Because it is an organic compound or has certain hazards, the sturdy packaging can prevent the container from being damaged during transportation and causing it to leak. The packaging material must also be compatible with the compound and will not react.
Fourth, avoid contact with oxidants and other substances. 2-Amino-5-methylthiophene-3-carboxylate ethyl ester has a specific chemical activity. Contact with oxidants or cause violent reactions, even causing ignition and explosion. When storing and transporting, it should be placed and transported separately from dangerous goods such as oxidants.
Fifth, do a good job of marking. Storage containers and transportation tools should be clearly marked with the name, properties, and dangerous precautions of the compound, so that relevant personnel can know that there are evidence to follow during operation and emergency treatment to ensure the safety of storage and transportation.