What is the chemical structure of ethyl 2- {[ (2,6-difluorophenyl) methyl] (ethoxycarbonyl) amino} -4-methyl-5- (4-nitrophenyl) thiophene-3-carboxylate?

The concept of "ethyl + 2- {[ (2,6 - difluorophenyl) methyl] (ethoxycarbonyl) amino} -4 - methyl - 5 - (4 - nitrophenyl) thiophene - 3 - carboxylate" is the English name of an organic compound. To clarify its chemical structure, it is necessary to analyze it according to the naming rules of organic chemistry.

"ethyl", ethyl is one of the substituents of the compound and is attached to the main chain. "2 - {[ (2,6 - difluorophenyl) methyl] (ethoxycarbonyl) amino}" part has a complex substituent in the second position of the main chain. Where " (2,6 - difluorophenyl) methyl", meaning 2,6 - difluorophenyl methyl, the phenyl group at the 2,6 positions is substituted with fluorine atoms and is connected to methyl; " (ethoxycarbonyl) amino" is ethoxycarbonyl amino, which is connected to the main chain.

"4 - methyl" indicates that the fourth position of the main chain has methyl; "5 - (4 - nitrophenyl) " indicates that the fifth position of the main chain is connected with 4 - nitrophenyl; "thiophene - 3 - carboxylate" indicates that the main chain has a thiophene structure and is connected with a carboxyl-derived ester group at the 3rd position.

In summary, this compound takes thiophene as the core main chain, and has specific substituents at positions 2, 4, and 5, respectively, and 3 are carboxyl-derived ester groups. Its structure is complex and delicate, and it is formed by the orderly combination of various functional groups, showing the wonders of organic chemical structure.

What are the main uses of ethyl 2- {[ (2,6-difluorophenyl) methyl] (ethoxycarbonyl) amino} -4-methyl-5- (4-nitrophenyl) thiophene-3-carboxylate?

Ethyl + 2 - {[ (2,6 - difluorophenyl) methyl] (ethoxycarbonyl) amino} -4 - methyl - 5 - (4 - nitrophenyl) thiophene - 3 - carboxylate, Chinese name or ethyl 2 - {[ (2,6 - difluorophenyl) methyl] (ethoxycarbonyl) amino} -4 - methyl - 5 - (4 - nitrophenyl) thiophene - 3 - carboxylate, this is an organic compound that plays an important role in many fields.

In the field of medicinal chemistry, it may be a key pharmaceutical intermediate. People in organic synthetic chemistry often use this as a starting material and go through a series of delicate chemical reactions to carefully construct complex compound structures with specific biological activities. Through ingenious modification and modification of its structure, it is very likely to develop new drugs with excellent efficacy and minimal side effects, contributing to human health.

In the field of materials science, such organic compounds have also made a name for themselves. Because of their unique molecular structure, they may endow materials with certain special properties. For example, introducing them into polymer materials may improve the optical properties, electrical properties or thermal stability of materials, thus preparing high-performance materials suitable for different scenarios, such as new optoelectronic materials, which can be used in electronic displays, optoelectronic devices and other fields.

Furthermore, in the study of organic synthesis methodology, ethyl + 2 - {[ (2,6 - difluorophenyl) methyl] (ethoxycarbonyl) amino} -4 - methyl - 5 - (4 - nitrophenyl) thiophene - 3 - carboxylate can serve as a model compound. With the help of in-depth exploration of various reactions using it as a substrate, such as fine optimization of reaction conditions and in-depth analysis of reaction mechanisms, researchers have contributed to the development of organic synthesis chemistry, promoted the continuous innovation and improvement of organic synthesis methods, and provided a solid theoretical foundation and practical experience for the efficient synthesis of more complex organic compounds.

What is the synthesis method of ethyl 2- {[ (2,6-difluorophenyl) methyl] (ethoxycarbonyl) amino} -4-methyl-5- (4-nitrophenyl) thiophene-3-carboxylate?

To prepare ethyl 2- {[ (2,6 -difluorophenyl) methyl] (ethoxycarbonyl) amino} -4 -methyl-5- (4 -nitrophenyl) thiophene-3 -carboxylic acid ester, the synthesis method is as follows:
Starting with 2,6 -difluorobenzaldehyde as the starting material, with ethoxyacetyl chloride under the catalysis of a suitable base, such as triethylamine, in a suitable organic solvent, such as dichloromethane, condensation reaction. This reaction needs to be controlled at a low temperature, between about 0 ° C and 5 ° C, ethoxyacetyl chloride is slowly added dropwise, and after several hours, when the reaction is complete, the product is purified by conventional methods, such as washing with water, drying, and distillation under reduced pressure.
Then, the resulting product is mixed with 4-methyl-5- (4-nitrophenyl) thiophene-3-carboxylic acid in a condensing agent, such as dicyclohexyl carbodiimide (DCC), and the catalyst 4-dimethylaminopyridine (DMAP). The reaction is stirred at room temperature in an anhydrous organic solvent, such as tetrahydrofuran. After a few hours, the reaction system is filtered to remove the formed dicyclohexyl urea precipitation, and the filtrate is separated by column chromatography to obtain an intermediate product.
Finally, this intermediate product is esterified with ethanol under the catalysis of strong acid, such as concentrated sulfuric acid, under the condition of heating and reflux. After a few hours, the reaction is completed, the reaction liquid is cooled, poured into ice water, extracted with an organic solvent, combined with the organic phase, dried with anhydrous sodium sulfate, distilled under reduced pressure to remove the solvent, and then recrystallized to obtain the target product ethyl 2- {[ (2,6-difluorophenyl) methyl] (ethoxycarbonyl) amino} -4 -methyl-5- (4-nitrophenyl) thiophene-3 -carboxylic acid ester. The whole process requires attention to the control of reaction conditions, the purity of raw materials and reagents, and the purification operation after each step of the reaction to improve the yield and purity of the product.

What are the physical properties of ethyl 2- {[ (2,6-difluorophenyl) methyl] (ethoxycarbonyl) amino} -4-methyl-5- (4-nitrophenyl) thiophene-3-carboxylate?

Ethyl + 2 - {[ (2,6 - difluorophenyl) methyl] (ethoxycarbonyl) amino} -4 - methyl - 5 - (4 - nitrophenyl) thiophene - 3 - carboxylate is an organic compound. Its physical properties are quite important, which is related to the behavior of this compound in different scenarios.

Looking at its state, it often exists in a solid state. Due to the relatively strong intermolecular force, it takes the shape of a solid state at room temperature and pressure. This solid state gives it a certain stability and is easy to store and transport.

When it comes to the melting point, according to its molecular structure, it contains aromatic rings, ester groups and other groups, and the interaction is complex. It is expected that the melting point is quite high. The π-π stacking between aromatic rings and the interaction between polar groups such as ester groups all make the molecules closely arranged, requiring high energy to destroy the lattice and increase the melting point.

In terms of solubility, the compound contains hydrophobic aromatic rings, such as 2,6-difluorophenyl and 4-nitrophenyl, as well as hydrophobic ester groups and amino groups. Therefore, in organic solvents, such as dichloromethane, chloroform, etc., because the hydrophobic part is similar to that of organic solvents, it should have good solubility. In water, although there are polar groups, the hydrophobic part accounts for a large proportion and the overall solubility is not good. < Br >
In addition to density, the molecule contains atoms with relatively large atomic mass such as fluorine, nitrogen, and oxygen, and has a compact structure, which makes it denser or more dense than common organic solvents.

The physical properties of this compound, such as state, melting point, solubility, and density, play a key guiding role in its application in organic synthesis, drug development, and other fields.

What are the chemical properties of ethyl 2- {[ (2,6-difluorophenyl) methyl] (ethoxycarbonyl) amino} -4-methyl-5- (4-nitrophenyl) thiophene-3-carboxylate?

This is a compound named ethyl 2- {[ (2,6 - difluorophenyl) methyl] (ethoxycarbonyl) amino} -4 - methyl - 5 - (4 - nitrophenyl) thiophene - 3 - carboxylate. Its chemical properties are worth exploring.

Looking at its structure, it contains ester groups, amino groups, nitro groups and many other functional groups. Ester groups have hydrolysis properties. Under the catalysis of acids or bases, hydrolysis can produce corresponding acids and alcohols. In an alkaline environment, hydrolysis is more rapid, because bases can react with hydrolyzed acids, pulling the equilibrium to move towards hydrolysis.

Amino groups are basic and can react with acids to form salts. Under appropriate conditions, it can participate in nucleophilic substitution reactions, interact with halogenated hydrocarbons and other electrophilic reagents to form new carbon-nitrogen bonds.

Nitro has strong electron-absorbing properties, which can reduce the electron cloud density of the benzene ring and increase the difficulty of electrophilic substitution reactions on the benzene ring. However, it can be reduced under specific conditions, such as using iron and hydrochloric acid as reducing agents, and nitro can be gradually converted into amino groups.

In addition, the aromatic ring structure in the compound can undergo aromatic electrophilic substitution reactions such as halogenation, nitrification, and sulfonation due to the existence of π electron clouds. The sulfur atom in the thiophene ring also affects the electron cloud distribution and reactivity of the compound, or can participate in oxidation and other reactions.

The diverse functional groups of this compound endow it with rich chemical properties, which may have unique application and research value in the fields of organic synthesis, medicinal chemistry, etc.