Dibenzothiophene,4-bromo-

4-Bromo-dibenzothiophene, this is an organic compound. Its physical properties are quite important and are related to many practical applications.
Let's talk about the appearance first. Under normal temperature and pressure, 4-bromo-dibenzothiophene usually appears in solid form. Its color is mostly white to light yellow powder, which makes it unique in appearance.
In terms of melting point, 4-bromo-dibenzothiophene has a specific melting point. Accurate determination of its melting point is of great significance for the identification and purification of this compound. In the experimental operation, the melting point determination is a key step in determining the purity of the compound. The melting point of pure 4-bromo dibenzothiophene is relatively fixed. If it contains impurities, the melting point will change.
Solubility is also an important physical property. It is insoluble in water, and this property is due to the hydrophobic groups such as benzene and thiophene rings contained in its molecular structure, which makes it difficult for water molecules to interact with it. However, 4-bromo dibenzothiophene is soluble in some organic solvents, such as common dichloromethane, chloroform, toluene, etc. This solubility characteristic provides convenience for its operation in the process of organic synthesis and separation, and suitable solvents can be selected for reaction and purification according to this property.
In terms of density, although the specific value will vary slightly due to measurement conditions, the total density is in a specific range. Density data provide a basic reference for the material ratio and related process design in practical applications.
In addition, 4-bromo dibenzothiophene also has a certain volatility, but the volatility is weak. Under conventional conditions, the amount of volatilization is limited, but under heating or in a specific environment, its volatilization will change, which should be paid attention to when storing and using.

4-Bromodibenzothiophene, this is an organic compound. Its chemical properties are unique and interesting.
First of all, its physical properties are usually solid, and the melting point has a specific value due to the force between molecules. In organic solvents, it shows some solubility, but it has little solubility in water, because it is a non-polar molecule, and the force between water molecules is weak.
In terms of chemical activity, its benzene ring and thiophene ring structure give many reaction possibilities. Bromine atoms, as functional groups, are very active and can participate in nucleophilic substitution reactions. For example, under appropriate conditions, the halogen atom in the halogenated alkane can be replaced by nucleophilic reagents, and the bromine atom can also be replaced by nucleophilic groups such as hydroxyl and amino groups, thereby preparing a series of derivatives.
Furthermore, due to the existence of the conjugate system, the compound has a certain degree of electron delocalization and can participate in electron transfer reactions. In redox reactions, it either acts as an electron donor or a receptor, exhibiting unique electrochemical properties. Under light conditions, intramolecular electron transitions initiate photochemical reactions, or molecular rearrangements occur, or new active intermediates are generated, and subsequent reactions occur. In addition, the thiophene ring of this compound can also undergo some special reactions, such as the electrophilic substitution reaction on the thiophene ring. Under the action of suitable electrophilic reagents, new functional groups are introduced at specific positions of the thiophene ring to further enrich its chemical properties and derivation paths, providing many possibilities for the field of organic synthetic chemistry, and has potential application value in many fields such as materials science and medicinal chemistry.

4-Bromo-dibenzothiophene has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate.
First, when creating new sulfur-containing heterocyclic compounds, 4-bromo-dibenzothiophene can be substituted with many nucleophiles by virtue of its bromine atom activity. By carefully selecting nucleophiles, such as amines, alcohols, phenols, etc., diverse chemical bonds can be formed to synthesize heterocyclic products with unique structures and properties. These products may have potential biological activities in the field of medicinal chemistry, and are expected to become precursor compounds for new drugs and provide novel structural templates for pharmaceutical research and development.
Second, in the field of materials science, 4-bromo dibenzothiophene also plays an important role. It can be introduced into polymer, and the rigid planar structure of dibenzothiophene units can improve the thermal stability and mechanical properties of the polymer. At the same time, the existence of bromine atoms is conducive to subsequent functional modification of materials. For example, through further reaction of bromine atoms, groups with photoelectric activity are introduced to make the materials have unique photoelectric properties, which can be applied to the fabrication of photoelectric devices such as organic Light Emitting Diode (OLED) and organic solar cells, providing the possibility for the development of high-performance organic optoelectronic materials.
Furthermore, in the field of catalytic chemistry, 4-bromo-dibenzothiophene can be converted into ligands with special electronic structures through specific reactions. After these ligands are complexed with metal ions, the metal-ligand complex catalysts formed may exhibit excellent catalytic activity and selectivity in some organic reactions, providing a powerful catalytic system for the efficient progress of organic synthesis reactions.
Therefore, 4-bromo-dibenzothiophene plays an indispensable role in many fields such as organic synthesis, materials science, and catalytic chemistry, and is of great significance to promote the development of related fields.

There are several common methods for synthesizing 4-bromo dibenzothiophene.
One is to use dibenzothiophene as the starting material and prepare it by bromination reaction. In a suitable reaction vessel, dibenzothiophene is placed in an appropriate amount of organic solvents, such as dichloromethane, carbon tetrachloride, etc. Then, under the condition of low temperature and stirring, bromine or bromine-containing reagents, such as N-bromosuccinimide (NBS), are slowly added dropwise. Taking NBS as an example, the reaction is relatively mild and there are few side reactions. After the dropwise addition is completed, continue to stir to make the reaction fully proceed. The reaction progress can be monitored by thin-layer chromatography (TLC). When the raw material point disappears or reaches the expected reaction level, the reaction is terminated. The reaction solution is washed with alkali solution to remove unreacted bromine and acidic impurities, and then the solvent is removed by drying and rotary evaporation. The crude product can be obtained and further purified by means of column chromatography to obtain 4-bromo dibenzothiophene.
Second, dibenzothiophene can be activated first to change the electron cloud density on the thiophene ring, which is conducive to the substitution of bromine atoms. For example, dibenzothiophene is treated with an appropriate Lewis acid, such as aluminum trichloride, to form an activation intermediate. After that, a brominating reagent is added and reacted under mild conditions. During this process, Lewis acid can enhance the electrophilicity of the brominating reagent and promote the substitution reaction to the target product. The subsequent treatment steps are similar to the previous method. After washing, drying and purification, pure 4-bromo dibenzothiophene is obtained.
Furthermore, the method of transition metal catalysis can be used. Transition metals such as palladium and copper are used as catalysts, and with the assistance of ligands, dibenzothiophene is coupled with brominated reagents. For example, palladium catalysis is used, and a suitable palladium catalyst, such as tetra (triphenylphosphine) palladium (0), is selected with a specific ligand, and in the presence of a base, it reacts with brominated aromatics or other bromine sources. This method has high selectivity and relatively mild conditions, which can effectively avoid bromine substitution at other locations. After the reaction, 4-bromodibenzothiophene can be successfully prepared through separation and purification steps.

I look at you and ask, I am inquiring about the price range of 4-bromo dibenzothiophene on the market. However, this price often changes due to many factors, and it is difficult to determine the value.
First, purity is important. If the purity is high, close to 99% or even higher, it is suitable for high-end scientific research, pharmaceutical synthesis and other fine fields, and its price is high. Or tens to hundreds of yuan per gram. If it is used for specific drug research and development, the requirements for impurities are strict, and high-purity products are scarce, so the price is naturally high.
Second, the purchase volume is also heavy. If the purchase quantity is small, such as only a few grams, the retail price is higher. However, if a large number of purchases, such as kilograms, the unit price may drop significantly due to economies of scale. < Br >
Third, supply and demand have a great impact. If the market demand is strong, but there are few suppliers, the supply is in short supply, and the price will rise. On the contrary, if the supply exceeds the demand, the price may drop.
Fourth, the price varies depending on the source. Imported products, or due to quality control, transportation costs, etc., the price is higher than that of domestic products. If the technology of domestic products is mature and the cost is well controlled, the price may be close to the people.
To sum up, the price range of 4-bromo dibenzothiophene, a small amount of high-purity retail, per gram or tens to hundreds of yuan; large purchases, per gram or a few yuan to tens of yuan. The actual price shall be determined according to market conditions and specific trading conditions.