What is the chemical structure of D- (+) -Methyl-2- (2-thiopheneethylamino) -2- (2-chlorophenyl) acetate HCl?

D- (+) -Methyl 2- (2-thiopheneethylamino) -2- (2-chlorophenyl) acetate HCl is an organic compound. To clarify its chemical structure, when each part is carefully analyzed.

Its core structure is acetate, and the carboxyl group of acetic acid and the hydroxyl group of methanol are esterified to form this methyl acetate structure. On this main chain, there are two important substituents at position 2. One is 2-chlorophenyl, that is, there is a chlorine atom at position 2 of the benzene ring, and this phenyl group is connected to carbon at position 2 of the acetate ester. The second is the 2-thiophene ethyl amino group, which means that the second position of the thiophene ring is connected to ethyl group, and the other end of the ethyl group is connected to the amino group, which is then connected to the carbon at the second position of the acetate.

As for HCl, it shows that this compound is hydrochloric acid, that is, the organic base part forms a salt with hydrochloric acid, and the hydrogen ion in hydrochloric acid combines with the basic part of the organic structure, which is often used to improve the stability and solubility of the compound. In this way, the structure of this compound can be clearly identified.

What are the main uses of D- (+) -Methyl-2- (2-thiopheneethylamino) -2- (2-chlorophenyl) acetate HCl?

D- (+) -methyl-2- (2-thiopheneethylamino) -2- (2-chlorophenyl) acetate hydrochloride is an organic compound with many uses in the field of medicine and chemical industry.

In the process of pharmaceutical research and development, it is often used as a key intermediate. Due to its specific chemical structure, it can be ingeniously converted into compounds with specific pharmacological activities through a series of chemical reactions. Or it can be used to create new anti-depressant drugs. By precisely adjusting the molecular structure, it can optimize its ability to bind to neurotransmitter receptors, so as to regulate the balance of neurotransmitters and relieve depression symptoms. Or in the research and development of analgesic drugs, by modifying its structure to enhance its affinity with opioid receptors, in order to achieve efficient analgesia.

In the field of chemical production, it can be used as a starting material for the synthesis of special functional materials. Due to the structure of thiophene and chlorophenyl, the compound has unique electrical and optical properties. By rationally designing the synthesis route, it can be integrated into polymer materials to give the material special functions such as photoelectric conversion, fluorescence properties, etc., injecting vitality into the development of frontier fields such as organic electronics and optical materials.

With its unique chemical structure, this compound is like a cornerstone in the field of medicine and chemical industry, paving the way for innovative drug research and development and the creation of new materials, promoting the continuous development of related fields, and helping human health and scientific and technological progress.

What is the synthesis method of D- (+) -Methyl-2- (2-thiopheneethylamino) -2- (2-chlorophenyl) acetate HCl?

To prepare D- (+) -Methyl-2- (2 - thiopheneethylamino) -2- (2 - chlorophenyl) acetate HCl, the method is as follows:

Take 2 - chloroacetophenone as the starting material, treated with alkali, so that it occurs α - hydrogen halogenation reaction, 2 - chloro - 2 - halogenated acetophenone can be obtained, this step should pay attention to the reaction temperature and the amount of halogenated reagents, high temperature or excessive reagents, fear of polyhalogenation by-products.

The obtained 2-chloro-2-haloacetophenone reacts with potassium thioacetate and is replaced by nucleophilic substitution to generate 2-chloro-2-acetylthioacetophenone. This reaction should be carried out in a polar aprotic solvent to facilitate smooth reaction.

Then 2-chloro-2-acetylthioacetophenone is hydrolyzed under alkaline conditions to obtain 2-chloro-2-mercaptoacetophenone. The hydrolysis process needs to control the concentration of the base and the reaction time to prevent excessive hydrolysis.

Take 2-chloro-2-mercaptoacetophenone and react with 2-thiophenethylamine to form a Schiff base intermediate, followed by a suitable reducing agent, such as sodium borohydride, to reduce this intermediate, to obtain D- (+) -Methyl-2- (2 - thiopheneethylamino) -2- (2 - chlorophenyl) acetate.

Finally, D- (+) -Methyl-2- (2 - thiopheneethylamino) -2- (2 - chlorophenyl) acetate is reacted with hydrogen chloride gas or hydrochloric acid to obtain the target product D- (+) -Methyl-2- (2 - thiopheneethylamino) -2- (2 - chlorophenyl) acetate HCl. Pay attention to the amount of hydrogen chloride during the reaction to ensure the purity of the product. After each step of the reaction, it needs to be separated and purified, such as extraction, column chromatography, etc., to obtain high-purity intermediate products and final products.

What are the physical and chemical properties of D- (+) -Methyl-2- (2-thiopheneethylamino) -2- (2-chlorophenyl) acetate HCl?

D- (+) -Methyl 2- (2-thiopheneethylamino) -2- (2-chlorophenyl) acetate HCl is one of the organic compounds. Its physical and chemical properties have various characteristics.

Looking at its appearance, it may be white to off-white crystalline powder under normal conditions. This is because of its orderly molecular arrangement and stable interaction. Its solubility is quite important. It has good solubility in organic solvents such as ethanol and methanol. This is because the molecules and solvent molecules can form suitable intermolecular forces, such as hydrogen bonds, van der Waals forces, etc., to disperse the solute. However, its solubility in water is relatively limited because some groups in the molecular structure interact weakly with water molecules. < Br >
When it comes to the melting point, it has a specific value after measurement, which is the result of the interaction of intermolecular forces and lattice energy. When the temperature rises to the melting point, the thermal motion of the molecule intensifies, which is enough to overcome the lattice binding and cause the substance to change from solid to liquid state. Its stability is also exquisite. Under conventional conditions, if strong light, hot topics and strong oxidants are isolated, the chemical properties are relatively stable. In case of specific conditions, such as strong acid and strong alkali environment, sensitive chemical bonds in the molecular structure, such as ester bonds, amino groups, etc., or chemical reactions occur, resulting in structural changes.

In addition, its spectral properties are also of characterization significance. In infrared spectroscopy, specific functional groups such as carbonyl and amino groups of ester groups have characteristic absorption peaks at corresponding wavenumbers, which can be used to identify molecular structures. In nuclear magnetic resonance spectroscopy, hydrogen or carbon atoms in different chemical environments exhibit unique chemical shifts, providing key information for determining the molecular skeleton and substituent positions. These are all important physicochemical properties of the compound.

What are the precautions for the use of D- (+) -Methyl-2- (2-thiopheneethylamino) -2- (2-chlorophenyl) acetate HCl?

D- (+) -Methyl-2- (2-thiopheneethylamino) -2- (2-chlorophenyl) acetate HCl is an organic compound. During use, many precautions must be kept in mind.

First, safety protection is essential. This compound may be toxic and irritating. When exposed, it is necessary to wear appropriate protective equipment, such as gloves, goggles and laboratory clothes, to avoid direct contact with the skin and eyes. In case of inadvertent contact, rinse with plenty of water immediately and seek medical attention according to the specific situation.

Second, accurately control the dosage. Before use, it is necessary to understand its use and reaction mechanism in detail. According to the specific needs of the experiment or production, the dosage should be determined by accurate calculation and weighing to prevent improper dosage from causing experiment failure or creating safety hazards.

Third, store it properly. It should be stored in a dry, cool and well-ventilated place, away from fire, heat and oxidants, etc., to prevent it from deteriorating or causing dangerous reactions due to environmental factors. At the same time, the storage container should be well sealed to avoid moisture and volatilization.

Fourth, the operating environment should not be ignored. The operation should be carried out in a fume hood to ensure that harmful gases are discharged in time and avoid inhalation by operators. In addition, the equipment involved in the use process should be kept clean, dry and in good working condition so as not to affect the performance of the compound and the experimental results.

Fifth, the disposal of waste should also be in compliance. After use, the remaining compounds and related waste should not be discarded at will, and should be properly disposed of in accordance with local environmental regulations and laboratory regulations to prevent environmental pollution.