What is the main use of Bsmoc-OSu, N- (Benzo [b] thiophenesulfone-2-methoxycarbonyloxy) succinimide

Bsmoc-OSu, that is, N- (benzo [b] thiophene sulfone-2-methoxycarbonyl) succinimide, is a key use. It is mainly used in the field of organic synthesis and is often used as an important reagent. In the process of peptide synthesis, Bsmoc-OSu plays a role in protecting the amino acid group, which can avoid the unnecessary participation of the amino group in the side reaction during the reaction, so as to ensure the precise progress of the synthesis reaction in the expected direction.

Looking at the reaction mechanism, the Bsmoc part can be cleverly combined with the amino acid amino group to form a stable structure. When the protective group is to be removed later, the Bsmoc group can be removed under suitable conditions, so that the amino group can return to the active state, and then participate in the subsequent peptide bond formation and other reactions.

In addition, Bsmoc-OSu is also indispensable in the total synthesis of some complex natural products. Because it can effectively regulate the selectivity of reaction check points, it helps synthesizers to construct complex and specific structures. If the synthesis of natural products with specific activities requires connecting different amino acid residues in a predetermined order, Bsmoc-OSu can ensure the smooth progress of each step, and improve the yield and purity of the product. In short, in the stage of organic synthesis chemistry, Bsmoc-OSu plays an extremely important role with its unique properties.

What are the synthesis methods of Bsmoc-OSu, N- (Benzo [b] thiophenesulfone-2-methoxycarbonyloxy) succinimide

To prepare Bsmoc-OSu, that is, N- (benzo [b] thiophene sulfone-2-methoxycarbonyl) succinimide, you can do it according to the following method.

Take an appropriate amount of benzo [b] thiophene first, and make it sulfonate with specific reagents and conditions to obtain a benzo [b] thiophene sulfone derivative. This step requires temperature control, time control and the proportion of reactants to make the reaction proceed in the direction of generating the target sulfonated product.

Mix the obtained benzo [b] thiophene sulfone derivative with a methoxy carbonylation reagent, and carry out a methoxy carbonylation reaction in the presence of a suitable solvent and catalyst. This process requires attention to the pH and temperature changes of the reaction environment to ensure that the methoxycarbonyl group can accurately access the target position.

Take succinimide and make it and the above-mentioned methoxycarbonylated benzo [b] thiophene sulfone derivatives undergo a condensation reaction under the action of a condensing agent. Common condensing agents such as dicyclohexyl carbodiimide (DCC), etc., and 4-dimethylaminopyridine (DMAP) can be added as a catalyst to promote the efficient progress of the reaction. Close monitoring is required during the reaction. When the reaction reaches the expected level, the reaction should be terminated by an appropriate method. < Br >
After the reaction is completed, the product is purified by extraction, column chromatography and other means to remove unreacted raw materials, by-products and impurities, and finally obtain pure Bsmoc-OSu. Each step of the reaction requires fine operation and strict control of conditions to obtain the product with ideal yield and purity.

How stable is Bsmoc-OSu, N- (Benzo [b] thiophenesulfone-2-methoxycarbonyloxy) succinimide?

Bsmoc-OSu, that is, N- (benzo [b] thiophene sulfone-2-methoxycarbonyl) succinimide, the stability of this substance is very critical. In many chemicals, its stability is often affected by many factors.

bear the brunt, and temperature changes have a significant impact on it. At high temperatures, molecular activity intensifies, or chemical bonds are broken or rearranged, making the substance unstable. If it is in a low temperature environment, molecular activity is limited, and its stability can be guaranteed to a certain extent.

Furthermore, light is also an important factor. Light contains energy, or photochemical reactions, change the molecular structure. When exposed to strong light, this substance may accelerate decomposition or produce other changes, so it is necessary to preserve it in the dark for stability maintenance.

In addition, pH is also related to its stability. Under different acid and base conditions, the molecules of the substance may undergo reactions such as protonation and deprotonation, which change the charge distribution and structure of the molecule. Its stability can only be maintained in a suitable pH range.

Contact with other chemical substances may also initiate reactions. In case of strong oxidizing agents, reducing agents and other active substances, or structural changes caused by reactions such as oxidation and reduction, its stability will be damaged.

To maintain the stability of Bsmoc-OSu, it is necessary to control temperature, avoid light, maintain a suitable acid-base environment, and avoid contact with substances that may react. In this way, the stability of its structure and properties can be maintained as much as possible.

Bsmoc-OSu, N- (Benzo [b] thiophenesulfone-2-methoxycarbonyloxy) succinimide What are the precautions when storing

Bsmoc-OSu, that is, N- (benzo [b] thiophene sulfone-2-methoxycarbonyl) succinimide, this compound needs to pay attention to many key matters when storing.

First, temperature control is extremely important. It should be stored in a cool place, because high temperature can easily cause its chemical structure to change, or accelerate the decomposition rate. If the temperature is too high, the force between the atoms in the molecule will be affected, and chemical bonds may break, causing the compound to deteriorate, reducing its chemical activity and stability.

Second, humidity should not be ignored. It should be placed in a dry environment because it may be hygroscopic. After moisture absorption, it may cause reactions such as hydrolysis, destroying the molecular structure. If moisture is involved, react with some groups of the compound, change the chemical properties, and affect the subsequent use effect.

Third, avoid light. This compound may be sensitive to light, under light, or excite electron transitions within the molecule, triggering photochemical reactions and causing structural changes. Like the formation of a new compound, or the inactivation of the original active group.

Fourth, the choice of storage container is crucial. Use a chemically stable container that does not react with the compound. Such as glass containers, certain glass components or react with compounds, inert materials should be selected to prevent the introduction of impurities and affect the purity and quality of the compound.

In addition, the storage place should be kept away from dangerous items such as fire sources and oxidants. Due to its chemical properties or making it flammable and explosive under certain conditions, contact with oxidants or cause violent reactions, endangering storage safety.

When storing Bsmoc-OSu, careful consideration is required from temperature, humidity, light, container and surrounding environment, so as to ensure its quality and stability for subsequent use.

What is the market price range for Bsmoc-OSu, N- (Benzo [b] thiophenesulfone-2-methoxycarbonyloxy) succinimide

I don't know the price of "Bsmoc-OSu, N- (Benzo [b] thiophenesulfone-2-methoxycarbonyloxy) succinimide". This is a rather professional and rare chemical, and its price varies depending on various factors such as quality, purity, supplier, purchase quantity, etc.

To know its exact price, you should consult a firm specializing in chemical reagents and a chemical product trading platform. In the chemical market, such fine chemicals may have high prices due to difficulty in preparation and scarcity of raw materials; or they may have easy prices due to mass production and promotion.

Common chemical reagents, market prices are easy to find, but this special product is not widely used. Those who are familiar with it may need to check the chemical product directory in detail, or ask specialized suppliers to obtain its approximate price range. And the market conditions are changing rapidly, and the price also fluctuates accordingly. Therefore, if you want to get an accurate price, you should visit relevant channels in real time.