BENZOTHIOPHENE-4-CARBOXYLIC ACID

Benzothiophene-4-carboxylic acid has a wide range of uses and has important applications in many fields.
In the field of medicinal chemistry, it is often a key intermediate for the synthesis of drugs. Many drug molecules with specific biological activities depend on their unique chemical structures. For example, by modifying the specific position of p-benzothiophene-4-carboxylic acid, new drugs targeting specific disease targets, such as anti-tumor drugs, can be developed. Because its structure can interact with specific proteins or receptors in tumor cells, through clever design and synthesis, new anti-cancer drugs with high efficiency and low toxicity can be obtained, providing new strategies for tumor treatment. < Br >
In the field of materials science, it also shows extraordinary value. It can be used to prepare functional polymer materials and introduce them into the polymer skeleton, which can give the material unique photoelectric properties. The polymer synthesized from it may have good fluorescence properties and can be applied to organic Light Emitting Diode (OLED) to improve the display effect and luminous efficiency, making the display device clearer and more colorful. In addition, in the field of solar cells, materials containing benzothiophene-4-carboxylic acid structure may improve the photoelectric conversion efficiency of batteries, contributing to the development of clean energy.
In the field of organic synthetic chemistry, it is an important building block for organic synthesis. Chemists can derive its carboxyl groups through various chemical reactions, such as esterification and amidation, to construct complex organic molecular structures. The rigid and conjugated structure of its benzothiophene parent nucleus lays the foundation for the synthesis of compounds with special spatial structures and electronic properties, contributes to the development of organic synthetic chemistry, and expands the creation space of new organic compounds.

Benzothiophene-4-carboxylic acid is an important member of the family of organic compounds. Its physical properties are unique and of great research value.
Under normal temperature and pressure, it is often in a solid state, but the specific state may vary depending on the purity and crystallization conditions. The color of this compound is usually white to light yellow powder, with pure color and fine quality like dust.
When it comes to melting point, benzothiophene-4-carboxylic acid has a specific melting point range, which is of great significance for its identification and purity judgment. Generally speaking, the melting point is within a certain range. If the purity is extremely high, the melting point will be stable and accurate. In terms of boiling point, it needs to be determined under specific pressure conditions. Its boiling point reflects the strength of the intermolecular forces of the compound, which has a great influence on its separation and purification.
Solubility is also a key physical property. In organic solvents, benzothiophene-4-carboxylic acids exhibit different solubility characteristics. Such as common polar organic solvents, some of them are miscible with them, while in non-polar solvents, their solubility may be extremely limited. In water, its solubility is very small, which is due to the poor matching of molecular structure polarity with water molecules.
Density is another physical parameter that characterizes its unit volume mass. This value is relatively stable and less affected by external conditions, which is of great significance for the quantitative research and practical application of compounds.
In addition, the crystal structure of benzothiophene-4-carboxylic acid is also unique. It can be seen by X-ray diffraction and other techniques that its molecular arrangement is orderly, the bonding mode between atoms and the spatial configuration are stable, and this structure lays the foundation for its physical and chemical properties.
In summary, the physical properties of benzothiophene-4-carboxylic acid are diverse and complex, and each property is interrelated, which has far-reaching significance for its application in organic synthesis, drug development, materials science and other fields.

Benzothiophene-4-carboxylic acid, this physical property is relatively stable. Looking at its molecular structure, it is fused by a benzene ring and a thiophene ring, and is connected with a carboxyl group. The benzene ring and the thiophene ring have a conjugated system, which endows the molecule with certain stability. The conjugated structure makes the electron cloud distributed uniformly, enhances molecular cohesion, and decreases reactivity.
Although the carboxyl group has certain reactivity and can participate in a variety of reactions, under certain conditions, the benzothiophene-4-carboxylic acid as a whole can still maintain relative stability. For example, under extreme conditions such as room temperature, room pressure, and no strong oxidants, strong acids, and strong bases, it can be stored for a long time without significant deterioration.
But in case of specific reagents, it will also react. In case of strong reducing agent, the carboxyl group may be reduced; in case of alkali, the carboxyl group will form a salt. However, in general, under conventional laboratory and industrial storage conditions, without the interference of improper environmental factors, the chemical properties of benzothiophene-4-carboxylic acid are relatively stable, which can maintain its inherent structure and characteristics, providing a reliable basis for related research and applications.

The synthesis method of benzothiophene-4-carboxylic acid has always been studied by chemical experts. In the past, one of the methods was to use sulfur-containing aromatic compounds as starting materials and convert them in multiple steps. First, the aryl halide and sulfur-containing reagents undergo nucleophilic substitution reaction under suitable reaction conditions, such as in the presence of inert gas protection, specific catalysts and bases, to form a thioether structure. This step requires fine regulation of temperature, reaction duration and material ratio. Too high or too low temperature, improper duration or imbalance of the ratio can all lead to poor reaction yield.
Then, the thioether structure is cyclized. It is often catalyzed by Lewis acid or other suitable cyclization reagents to induce intramolecular cyclization to form the parent nuclear structure of benzothiophene. This process also requires strict control of the reaction conditions. The polarity of the solvent and the amount of catalyst all affect the efficiency and selectivity of cyclization.
Furthermore, carboxylation of the parent nucleus of benzothiophene is carried out. The common method is to react with metal-organic reagents and carbon dioxide to introduce carboxyl groups at specific positions in the parent nucleus. For example, using Grignard reagent or lithium reagent, under harsh conditions of low temperature, anhydrous and oxygen-free, it reacts with carbon dioxide gas to obtain benzothiophene-4-carboxylic acid. However, this process requires extremely high operation, and the reaction can fail if the reagent is damp or in contact with air. < Br >
Another way is to use specific heterocyclic compounds as raw materials and transform and modify them by functional groups. First, ring-opening or ring-expanding reactions are carried out on the heterocyclic ring to construct the basic structure of benzothiophene, and then a series of reactions such as oxidation and substitution are carried out to introduce carboxyl groups at the target position. However, such methods are cumbersome, each step requires precise operation, and the control of the reaction conditions cannot be slack in the slightest to obtain the ideal yield and purity.

The price of benzothiophene-4-carboxylic acid in the market is difficult to determine. According to Guanfu's "Tiangong Kaiwu", the price of various materials often varies with time, place and quality. The same is true for this benzothiophene-4-carboxylic acid.
The change in its price depends first on the place of origin. If the place of origin is close to the user and the transportation capital is saved, the price may be slightly cheaper; if the place of origin is remote, the transshipment is difficult, and the cost is high, the price will be expensive.
The second time is related to supply and demand. If there are many people in demand in the market, but there are few producers, the supply is in short supply, and the price will be high; if there are many producers, but there are few people in demand, the supply will exceed the demand, and the price will tend to be low.
Furthermore, the quality is also the key to the price. Those with excellent quality are valued by users, and the price is often high; those with poor quality are limited in use, and the price will be low.
I have heard that in the market, the price ranges from a few yuan to tens of yuan per gram. However, this is only a rough number. The actual price must be consulted with chemical material suppliers or observed on the trading platform to know the exact number. And the market conditions are ever-changing, and the price is also impermanent. It is necessary to explore in real time to obtain an accurate price.