Benzothiophene-3-Carboxaldehyde

Benzothiophene-3-formaldehyde has a wide range of uses. In the field of medicinal chemistry, it is often a key raw material for the creation of new drugs. The special structure of Geiinbenzothiophene endows compounds with unique physiological activities. It can design and synthesize drugs for a variety of disease targets, such as anti-cancer, antiviral and neurological diseases. It is of great significance to human health.
In the field of materials science, it also plays an important role. It can be used as a starting material for the synthesis of materials with special properties, and polymer materials with unique photoelectric properties can be constructed through specific reactions. Such materials show good application prospects in optoelectronic devices such as organic Light Emitting Diode (OLED) and solar cells, which can improve device performance and efficiency.
Furthermore, in organic synthetic chemistry, benzothiophene-3-formaldehyde, as an important intermediate, participates in the construction of many complex organic molecules. With the active chemical properties of its aldehyde groups, different functional groups can be introduced through classical organic reactions, such as aldehyde-alcohol condensation, nucleophilic addition, etc., to expand the diversity of molecular structures, and help organic chemists create organic compounds with novel structures and unique functions, promoting the development of organic synthetic chemistry.

Benzothiophene-3-formaldehyde is one of the organic compounds. Its physical properties are quite important and are often used in various fields of chemical industry.
Looking at its appearance, benzothiophene-3-formaldehyde is mostly light yellow to yellow crystalline powder at room temperature. This color state is easy to intuitively identify, and can provide practitioners with preliminary judgment basis in actual operation and application.
When it comes to melting point, the melting point of this compound is about 58-62 ° C. The characteristics of melting point are of great significance in the purification and identification of substances. By measuring the melting point, its purity can be verified. If the melting point of the sample matches or is similar to the known standard melting point, and the melting range is narrow, its purity can be inferred to be higher. On the contrary, if the melting point deviates greatly and the melting range is wide, the purity is not good.
The boiling point of benzothiophene-3-formaldehyde also has its specific value, which is about 325-327 ° C. The boiling point reflects the temperature conditions required for the substance to change from liquid to gaseous state. In chemical operations such as distillation and separation, the boiling point data provides key parameters for precise control of reaction conditions, helping to achieve effective separation and purification of substances.
Furthermore, its solubility is also an important physical property. Benzothiophene-3-formaldehyde is soluble in common organic solvents such as dichloromethane, chloroform, and tetrahydrofuran. This solubility characteristic enables it to build a homogeneous reaction system with the help of suitable solvents in organic synthesis reactions, promoting sufficient contact and reaction between reactants, thereby improving reaction efficiency and yield.
Its density is also characterized, although the exact value varies slightly due to measurement conditions, it is roughly within a certain range. Density information has reference value in material accounting, storage and transportation, etc., and is related to cost accounting and safety assurance in the production process.
In addition, benzothiophene-3-formaldehyde is volatile to a certain extent and will slowly evaporate into the air under certain circumstances. This characteristic should be taken into account when storing and using. It should be ensured that the storage environment is well sealed and the operating space is well ventilated to avoid loss or safety problems caused by its volatilization.

To prepare benzothiophene-3-formaldehyde, there are many methods, and the common ones are as follows.
First, benzothiophene is used as the starting material and can be obtained by Vilsmeier-Haack reaction. In this reaction, N, N-dimethylformamide (DMF) and phosphorus oxychloride (POCl) are used as reagents, and the two interact first to form an active intermediate. Benzothiophene reacts with this active intermediate and introduces a formyl group at the 3rd position of the thiophene ring to obtain benzothiophene-3-formaldehyde. When reacting, it is necessary to pay attention to the control of temperature. Generally, it starts at a low temperature and gradually rises to a moderate temperature to ensure a smooth reaction and improve the purity and yield of the product.
Second, through metal catalytic coupling reaction. For example, benzothiophene is first halogenated to obtain halogenated benzothiophene, such as bromobenzothiophene. After that, palladium-catalyzed coupling reaction is used, and carbon monoxide (CO) is used as a formyl source to co-react with a suitable base and a palladium catalyst. In this process, halogenated benzothiophene and CO undergo an insertion reaction under the action of palladium catalyst, thereby generating benzothiophene-3-formaldehyde. This method requires strict reaction conditions. The choice and dosage of catalysts, the type and dosage of bases all have a great impact on the reaction, and need to be carefully regulated.
Third, the compound containing the corresponding substituent is used as the raw material, and the benzothiophene ring is constructed through multi-step reaction and formyl is introduced. For example, the o-mercaptobenzoic acid derivative is reacted with halogenated olefins to first construct the benzothiophene ring, and then the target product is prepared through appropriate oxidation and formylation steps. Although this path has many steps, the reaction conditions of each step can be flexibly adjusted according to the characteristics of the raw materials and the needs of the reaction, so as to achieve the purpose of optimizing the synthesis.
All synthetic methods have their own advantages and disadvantages. In practical application, the optimal method should be selected based on factors such as the availability of raw materials, cost, difficulty in controlling reaction conditions, and the purity and yield of the target product.

At this time, it is not easy to know the market price of benzothiophene-3-formaldehyde. Prices in the city often change due to changes in time, place, quality and supply and demand. If it is said in ancient times, the price of this product in the market is still changing, and it is difficult to determine quickly.
In the past, the price of this product depended on merchants running around and communicating with each other to determine its value. In today's world, although the information is smooth, it is necessary to explore many ways to obtain an accurate price. It may vary depending on the place of origin, the quality is good and bad, and the price varies. For example, the price of high-quality benzothiophene-3-formaldehyde must be higher than that of ordinary people.
The supply and demand situation in the market also has a great impact on its price. If there are many people who want it, but there are few people who supply it, the price will increase; on the contrary, if the supply exceeds the demand, the price will fall. In addition, the process and cost of making this thing also affect its price. If the process is complicated and the cost is high, the price will not be low.
If you want to know its exact price, you should visit the cities like a good person in ancient times, consult all the merchants, scrutinize its quality, and measure its supply and demand, so that you can get a more accurate price. Don't listen to biases, and don't rely on your imagination. Only based on actual observation can you know the true price in the city.

Benzothiophene-3-formaldehyde is an organic compound. During storage and transportation, the following matters should be paid attention to:
First, the storage temperature is the most critical. It should be placed in a cool place, away from heat sources and open flames. Because the compound is prone to chemical reactions when heated, it may even cause the risk of combustion and explosion. Generally speaking, the storage temperature should be controlled between 15 ° C and 25 ° C. This temperature range can ensure the relative stability of its chemical properties.
Second, the dryness of the storage environment cannot be ignored. Benzothiophene-3-formaldehyde is easily affected by water vapor. If the environmental humidity is too high, or it causes adverse reactions such as hydrolysis, the quality will be damaged. Therefore, it should be stored in a dry place, and an appropriate amount of desiccant can be placed in the storage container to maintain the dryness of the environment.
Third, the material of the storage container must be carefully selected. Corrosion-resistant materials should be used, such as glass or containers made of specific plastic materials. Due to its active chemical properties, if it comes into contact with or reacts with unsuitable materials, it will change its chemical composition.
Fourth, during transportation, it is necessary to ensure the stability of the container. Avoid violent vibration and collision to prevent the leakage of benzothiophene-3-formaldehyde due to the rupture of the container. And the transportation vehicle should also be equipped with corresponding emergency treatment equipment for emergencies.
Fifth, whether it is storage or transportation, it is necessary to strictly follow relevant regulations and standards. This compound may belong to the category of hazardous chemicals and should be labeled, packaged, and transported in accordance with regulatory requirements to ensure the safety of personnel and the environment.