7-fluoro-1-benzothiophene-2-carboxylic acid

7-Fluoro-1-benzothiophene-2-carboxylic acid, that is, 7-fluoro-1-benzothiophene-2-carboxylic acid, has the following chemical structure.
This compound is derived from the benzothiophene ring system. The benzothiophene ring is formed by fusing a benzene ring with a thiophene ring by sharing two adjacent carbon atoms. In this structure, the position 7 of the benzothiophene ring is replaced by a fluorine atom, and a carboxyl group (-COOH) is connected at position 2.
The benzothiophene ring, as the parent nuclear structure, endows the whole compound with specific aromaticity and electron cloud distribution characteristics. The substitution of fluorine atom as an electron-withdrawing group at position 7 has a significant impact on the electron cloud density and chemical properties of the benzothiophene ring. On the one hand, the strong electronegativity of fluorine atom makes it attract electrons from the benzothiophene ring, which changes the electron cloud distribution on the ring, thereby affecting the reactivity and stability of the compound. On the other hand, the carboxyl group at position 2, because of its acidic hydrogen and carboxyl reactivity, can participate in a variety of chemical reactions, such as salt formation reaction, esterification reaction, etc., which greatly enriches the application of 7-fluoro-1-benzothiophene-2-carboxylic acid in the field of organic synthesis. Its overall structure is unique, and these structural characteristics jointly determine the physical and chemical properties of the compound and its potential application value in organic chemistry, pharmaceutical chemistry and other fields.

7-Fluoro-1-benzothiophene-2-carboxylic acid has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate for the creation of new drugs. The structure of Gein-benzothiophene is quite common in many bioactive molecules, and the fluorine atoms and carboxyl groups carried by 7-fluoro-1-benzothiophene-2-carboxylic acids can significantly adjust the physical, chemical and biological properties of molecules. For example, the introduction of fluorine atoms often enhances the binding force between drugs and targets, improves pharmacokinetic properties, such as enhancing lipophilicity, and helps drugs penetrate biofilms, thereby increasing bioavailability. < Br >
It is also useful in materials science. It can participate in the synthesis of materials with special optoelectronic properties. Due to the characteristics of molecular structure, it may endow materials with unique electronic conductivity and optical properties. Taking organic semiconductor materials as an example, 7-fluoro-1-benzothiophene-2-carboxylic acid can be chemically modified and polymerized appropriately, or materials can be prepared for use in devices such as organic light emitting diodes (OLEDs) and organic field effect transistors (OFETs), which are expected to improve the performance and efficiency of devices.
Furthermore, in the field of agricultural chemistry, there are also potential applications. Or it can be used as a raw material for the synthesis of new pesticides. With its structural characteristics, compounds with efficient control effects on specific pests and diseases can be designed, and the presence of fluorine atoms may reduce the residues of pesticides in the environment and improve their environmental friendliness. In short, 7-fluoro-1-benzothiophene-2-carboxylic acid has shown important application value in many fields, providing new opportunities and possibilities for innovation and development in various fields.

The synthesis of 7-fluoro-1-benzothiophene-2-carboxylic acid has been around since ancient times. In the past, the Fang family used a delicate method to make this strange thing.
One method is to use fluorinated benzothiophene as the starting material and go through the acylation process. First take an appropriate amount of fluorobenzothiophene, put it in a clean kettle, and add a suitable acylating agent, such as an acyl halide or an acid anhydride. Add a catalytic agent to make the reaction smooth. Control its temperature, adjust its pressure, and in a quiet environment, promote acylation. After acylation, after separation and purification, 7-fluoro-1-benzothiophene-2-carboxylic acid can be obtained.
Another method involves benzothiophene as a group, first halogenated, and fluorine atoms are introduced. Benzothiophene is placed in various reactors, and a halogenating agent is selected, especially a heavy fluorine halogenating agent. After halogenation, a fluorine-containing benzothiophene intermediate is obtained. Following the method of carboxylation, a carboxylating agent, such as a carboxylated salt, is added under moderate temperature and pressure to connect the carboxyl group, and finally 7-fluoro-1-benzothiophene-2-carboxylic acid is formed. In addition, there may be a method of transformation starting with other substances and going through several steps. For example, an aromatic compound with a specific structure can be used as the end, and this purpose can also be achieved through various steps such as cyclization, fluorination, and carboxylation. Each step needs to be carefully studied, controlled its conditions, and observed changes to ensure a smooth synthesis path and a pure product. This is the method of synthesis left by predecessors, which can be used for future generations to study this substance.

7-Fluoro-1-benzothiophene-2-carboxylic acid, this substance is white to off-white crystalline powder, with a fine texture, like fine snow. It is quite stable under normal conditions, but when it encounters hot topics, open flames or strong oxidants, it is like a sleeping beast being disturbed and easily dangerous. It needs to be properly stored in a cool, dry and well-ventilated place, away from fire and heat sources, to prevent accidents.
When it comes to solubility, it can be moderately dissolved in organic solvents, such as methanol, ethanol, dichloromethane, etc., like fish in water, but in water, it seems to be rejected thousands of miles away, and the solubility is poor. This property is crucial in the extraction and separation steps of chemical synthesis.
Its melting point is roughly in a specific range, which is like an accurate ruler, becoming an important basis for identifying its purity. The higher the purity, the closer the melting point is to the theoretical value, and the deviation is minimal.
In the stage of chemical reactions, 7-fluoro-1-benzothiophene-2-carboxylic acids exhibit unique activities due to the unique properties of fluorine atoms, benzothiophene rings and carboxyl groups in their structures. Carboxyl groups are like active dancers, easy to dance with alcohols. Under the catalysis of concentrated sulfuric acid, esterification reactions take place enthusiastically to generate different compounds; fluorine atoms are like hidden strategists, subtly affecting the electron cloud distribution of molecules, affecting the process and direction of the reaction, opening many possible doors for the field of organic synthesis, and playing an indispensable role in many fields such as pharmaceutical chemistry and materials science. For example, in the development of new drugs, it has become a key cornerstone for exploring unknown therapeutic effects.

The price range of 7-fluoro-1-benzothiophene-2-carboxylic acid in the market is difficult to determine. The price of this product often changes due to multiple reasons.
The price of all kinds of materials in the past was often tied to the trend of supply and demand. If there are many people in the market who ask for 7-fluoro-1-benzothiophene-2-carboxylic acid, and there are few people who supply it, the price will rise; on the contrary, if the supply exceeds the demand, the price may drop.
Furthermore, the place where it is produced and the method used are also related to the price. The place of origin is different, the raw materials and labor costs are different, and the price is different. And if the preparation method is new and good, saving materials and time, the price may be lower; if the old method is difficult and time-consuming, the price may be higher.
And the quality is also a variable of price. Those with high quality must be higher than those who are ordinary. However, the price of 7-fluoro-1-benzothiophene-2-carboxylic acid per gram ranges from tens to hundreds of yuan. This is only an approximate number. The actual price needs to be consulted with various suppliers, and it is difficult to determine depending on time. If you want to know the exact price, you must carefully check the market conditions and visit the seller before you can get it.