6-methyl-1-benzothiophene-2-carboxylic acid

6-Methyl-1-benzothiophene-2-carboxylic acid, its chemical structure is as follows:
The core structure of this compound is a benzothiophene ring, which is formed by fusing a benzene ring with a thiophene ring. At the 1st position of the benzothiophene ring, a sulfur atom participates in the ring formation; at the 6th position, a methyl group is connected, that is, a -CH 🥰 group; and at the 2nd position, a carboxyl group is connected, that is, a -COOH group. From the perspective of spatial structure, the benzothiophene ring exhibits a certain planarity, and the methyl and carboxyl groups extend outward at specific positions in the ring plane. This structure endows 6-methyl-1-benzothiophene-2-carboxylic acid with unique physical and chemical properties, and has potential applications in many fields such as organic synthesis and drug development.

6-Methyl-1-benzothiophene-2-carboxylic acid, which has a wide range of uses. In the field of medicinal chemistry, it is often a key raw material for the creation of new drugs. Because of its unique chemical structure and activity, it may be able to develop therapeutic drugs with significant efficacy for specific diseases, such as inflammation, tumors, etc. For example, by modifying its structure, compounds with high affinity to specific biological targets can be synthesized to achieve precision medicine.
It is also useful in the field of materials science. It may be used as a basic unit for building materials with special properties. For example, it can be combined with other organic or inorganic materials to prepare functional materials with special optical, electrical or thermal properties, which can be used in optoelectronic devices, sensors and other fields to improve the performance and sensitivity of equipment.
In the field of organic synthetic chemistry, 6-methyl-1-benzothiophene-2-carboxylic acid can be used as an important intermediate. With its active carboxyl group and benzothiophene structure, many organic compounds with complex structures and special functions can be derived through various organic reactions, such as esterification, amidation, etc., which contribute to the development of organic synthetic chemistry. In conclusion, 6-methyl-1-benzothiophene-2-carboxylic acid has shown important value and broad application prospects in many fields due to its unique chemical properties.

The synthesis method of 6-methyl-1-benzothiophene-2-carboxylic acid is often based on the classical organic synthesis path. One method can start from thiophenol with appropriate substituents. First, the nucleophilic substitution reaction of thiophenol and halogenated olefins in the presence of suitable bases and solvents is carried out to obtain the alkenyl sulfide intermediate. This step requires mild reaction conditions to prevent overreaction and damage to the purity of the product.
The obtained alkenyl sulfide is followed by cyclization. Under specific catalyst and heating conditions, the alkenyl sulfide undergoes intramolecular cyclization to construct the core structure of benzothiophene. In this cyclization step, the reaction temperature and catalyst dosage need to be precisely controlled in order to obtain 6-methyl-1-benzothiophene with high yield and high selectivity.
After obtaining 6-methyl-1-benzothiophene, the carboxyl group can be introduced through the lithium reaction. 6-methyl-1-benzothiophene is treated with n-butyl lithium and other reagents, and the benzothiophene is lithium at a specific position at a low temperature to form a lithium intermediate. Subsequently, carbon dioxide gas is introduced into the reaction system, and the lithium intermediate interacts with carbon dioxide to form a carboxylate. Finally, after acidification treatment, 6-methyl-1-benzothiophene-2-carboxylic acid can be obtained.
Another method may start from the sulfur-containing aromatic compound and combine it with a multi-step substitution and cyclization reaction. First, a halogen atom is introduced at a specific position in the aromatic ring through a halogenation reaction. Then, through a metal-catalyzed coupling reaction, it is connected to a sulfur reagent containing an alkenyl group or an alkynyl group. Subsequently, through cyclization and functional group conversion, the structure of the target molecule is gradually constructed, and the final 6-methyl-1-benzothiophene-2-carboxylic acid is obtained. During each step of the reaction, attention should be paid to the separation and purification of the intermediate to ensure that the reaction proceeds according to the predetermined path and improves the quality and yield of the product.

6-Methyl-1-benzothiophene-2-carboxylic acid is one of the organic compounds. It has specific physical properties, so let me tell you one by one.
Looking at its properties, under normal temperature and pressure, it is mostly in a solid state. The appearance of this substance is usually white to light yellow crystalline powder, with a fine texture, like fine sand. Its particles are uniform and flicker slightly under light, like starry spots.
Talking about the melting point, the melting point of 6-methyl-1-benzothiophene-2-carboxylic acid is quite high, between about 180-185 ° C. This property allows it to remain stable in a solid state at normal ambient temperatures. If you want to melt it, you need to apply a higher temperature. Just as iron needs a strong fire to be cast, this substance also needs corresponding heat to change its shape.
In terms of solubility, it has little solubility in water, just like fish are difficult to grow in deserts. Due to the characteristics of its molecular structure, it is difficult to blend with water molecules. However, in organic solvents, such as common ethanol and dichloromethane, it has a certain solubility. In ethanol, it can be partially dissolved, making the solution slightly cloudy, like a mist. In dichloromethane, the solubility is relatively better, and a clearer solution can be formed, just like clear water reflects the moon.
The density of 6-methyl-1-benzothiophene-2-carboxylic acid is moderate, although there is no specific precise value, it is within a reasonable range compared with common organic compounds. The density makes it necessary to follow the corresponding rules during storage and transportation to prevent package damage due to density factors.
The stability of this substance cannot be ignored. Under normal storage conditions, in a dry, cool and well-ventilated place, it can maintain its own structure and properties stable. However, if it encounters strong oxidizing agents, strong acids or strong bases, its structure may be damaged and chemical reactions will occur, like a fragile boat encountering strong winds and waves.
The above is the main physical property of 6-methyl-1-benzothiophene-2-carboxylic acid, which is of great significance for its research and application.

The market price of 6-methyl-1-benzothiophene-2-carboxylic acid is difficult to determine. This is due to various reasons for its price fluctuations.
Looking at past market conditions, the price of chemical products is often determined by supply and demand, the price of raw materials, the simplicity of the process, regulations and decrees. If the demand for this product is strong, and the production and supply are insufficient, the price will rise; on the contrary, if the supply exceeds the demand, the price may drop.
The cost of raw materials is also a major factor. If the price of the raw materials required for its synthesis increases, the price of 6-methyl-1-benzothiophene-2-carboxylic acid will also increase; if the price of raw materials decreases, its price may also decrease.
The complexity of the process is related to production capacity and cost. If the process is complicated, multiple processes, high-end equipment and sophisticated technology are required, and the cost is high and the price is not cheap; if the process is simple, the cost will decrease and the price will be low.
Furthermore, regulations and decrees have restrictions on the production, transportation and sales of chemical products. If the new regulations cause production restrictions, cost increases, prices may rise; conversely, if the policy is favorable, production and efficiency are promoted, prices may stabilize or decline.
Taking history as a mirror, the prices of similar chemicals often fluctuate. Therefore, if you want to know the exact current price of 6-methyl-1-benzothiophene-2-carboxylic acid, you should consult chemical raw material suppliers, traders, or check industry information platforms and market survey reports to get more accurate prices.