6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER

6-Bromo-benzo [b] thiophene-2-carboxylic acid methyl ester, this substance is widely used. In the field of pharmaceutical synthesis, it is often used as a key intermediate. The structure of Gainbenzothiophene is common in many drug active molecules. The introduction of bromine atoms and methyl ester groups can be used by organic synthesis to modify and construct complex drug molecular structures with specific activities.
In the field of materials science, compounds containing benzothiophene structures often have unique photoelectric properties. 6-Bromo-benzo [b] thiophene-2-carboxylic acid methyl ester can be further reacted and modified, or special optoelectronic materials can be prepared, such as applied to organic Light Emitting Diode (OLED), solar cells and other devices, to improve its photoelectric conversion efficiency, stability and other properties.
In addition, in the field of fine chemicals, it may be used to synthesize fine chemicals with special functions, such as some high-performance dyes, fragrance additives, etc. Due to the existence of bromine atoms and methyl ester groups, the compound is endowed with unique reactivity and chemical properties. It can prepare fine chemical products with specific functions and properties through various chemical reactions to meet different industrial and daily needs.

The method of synthesizing methyl 6-bromo-benzo [b] thiophene-2-carboxylic acid often follows various paths. First, benzo [b] thiophene-2-carboxylic acid can be started, and it can be esterified with methanol under the condition of acid catalysis. In this process, sulfuric acid or p-toluenesulfonic acid are used as catalysts, heated and refluxed to make the two fully react. After several hours, the reaction is completed, and the target product can be obtained by conventional separation and purification methods, such as extraction, distillation, column chromatography, etc.
Or, starting from 6-bromo-benzo [b] thiophene, the carboxyl group is first introduced through carboxylation reaction, and then esterified. When carboxylation, magnesium and 6-bromo-benzo [b] thiophene can be made into Grignard reagent by Grignard reagent method, and then react with carbon dioxide to obtain 6-bromo-benzo [b] thiophene-2-carboxylic acid, and then react with methanol to obtain 6-bromo-benzo [b] thiophene-2-carboxylic acid methyl ester.
Furthermore, a suitable substituted benzothiophene derivative can be used as a raw material to introduce bromine atoms through halogenation reaction, and then carboxylation and esterification steps can be carried out. During halogenation, a suitable halogenation reagent, such as N-bromosuccinimide (NBS), etc., is selected under appropriate reaction conditions, and bromine atoms are precisely introduced at the designated position, and the subsequent carboxylation and esterification are completed in sequence, and the desired product is finally obtained. Each method has its advantages and disadvantages, and it needs to be used according to the actual situation, such as the availability of raw materials, the difficulty of reaction, and the consideration of cost.

6-Bromo-benzo [b] thiophene-2-carboxylic acid methyl ester, this is an organic compound. Looking at its structure, it contains a benzothiophene ring, with bromine atom substitution at 6 positions on the ring, and the 2 positions are connected with carboxylic acid methyl ester groups. Its physical and chemical properties are as follows:
- ** Properties **: Under normal circumstances, it is mostly white to light yellow crystalline powder, which is caused by molecular arrangement and light reflection and absorption characteristics.
- ** Melting point **: about 85-89 ° C. When heated to this temperature range, the molecules are energized, the lattice is destroyed, and the solid state is converted from a liquid state. < Br > - ** Boiling point **: Due to the presence of aromatic rings and heterocycles in the structure, the intermolecular force is strong and the boiling point is high. Under a certain pressure, it boils at about 290-300 ° C, and the liquid phase molecules obtain enough energy to overcome the intermolecular attractive force and escape into the gas phase.
- ** Solubility **: It is difficult to dissolve in water, because it is an organic compound, the molecular polarity is weak, and the polar solvent of water has a small force and is incompatible; but it is soluble in common organic solvents, such as dichloromethane, chloroform, tetrahydrofuran, etc., because of "similar miscibility", it is similar to the polarity of organic solvents, and the intermolecular interaction is easy to dissolve.
- ** Stability **: It is relatively stable under normal conditions. However, in the case of strong oxidants, oxidation reactions can occur due to active parts such as bromine atoms and thiophene rings in the structure; in strong acid, strong alkali environment and high temperature, ester groups may be hydrolyzed to produce 6-bromo-benzo [b] thiophene-2-carboxylic acid and methanol.
- ** Spectral properties **: In the infrared spectrum, there is a strong absorption peak at about 1720-1750 cm fond, which is derived from the stretching vibration of ester carbonyl; the absorption peak at about 1250-1300 cm fond corresponds to the C-O-C stretching vibration. In hydrogen nuclear magnetic resonance spectroscopy, hydrogen atoms in different chemical environments have different chemical shifts, which can be used to analyze molecular structures.

6-Bromo-benzo [b] thiophene-2-carboxylic acid methyl ester, which is a valuable organic compound in the field of fine chemicals, is widely used in medicine, pesticides, materials and many other industries. However, its price in the market often fluctuates due to multiple factors, and it is difficult to generalize.
Let's talk about purity first, which is a key factor affecting the price. For high purity, the preparation process is complicated and costly, so the price is very high. If the purity reaches more than 98%, it is mostly used in pharmaceutical research and development and high-end material synthesis, and the price per gram may be hundreds of yuan or even higher. However, those with slightly lower purity, such as about 95%, may be suitable for general industrial use, and the price is relatively affordable.
Furthermore, the market supply and demand situation also affects its price. If the pharmaceutical industry has a large increase in demand for drugs containing this ingredient during a certain period of time, or the research and development of related new materials leads to an increase in demand, while the supply is relatively stable or the growth is slow, the price will rise. On the contrary, if the demand is low, manufacturers may reduce prices for promotional sales.
In addition, production costs are also closely linked to prices. Raw material prices, production equipment inputs, energy consumption and labor costs are all affected. If raw materials are scarce or prices fluctuate greatly, costs will rise, and product prices will also be adjusted accordingly. The complexity of the production process also plays a role. The cumbersome process requires more technology and resource investment, and the cost and price will also rise.
Regional differences also have a significant impact on prices. Different regions have different levels of economic development, market competition, and logistics costs. Economically developed regions have strong demand and intense competition, and prices may be more transparent and reasonable; remote areas may have higher prices due to high logistics costs.
Based on past market conditions, its prices generally fluctuate between tens of yuan and thousands of yuan per gram. However, if you want to know the exact price, you need to consult chemical raw material suppliers, chemical trading platforms or relevant distributors in real time to obtain accurate price information.

Methyl 6-bromo-benzo [b] thiophene-2-carboxylate is an organic chemical substance, and its storage conditions are crucial, which is related to the stability and quality of the substance. According to the ancient meaning of "Tiangong Kaiwu", the storage of such chemical substances requires many factors to be considered.
The first one to bear the brunt is the ambient temperature of storage. It should be stored in a cool place to avoid baking in the hot sun. If it is placed in a high temperature place, the thermal movement of the molecules will intensify, or chemical reactions will occur and the material will deteriorate. The temperature should be controlled in the low temperature range of 2-8 ° C. This temperature range can effectively slow down the molecular activity and maintain its chemical stability.
Second, the humidity should not be underestimated. It should be placed in a dry place to avoid the intrusion of water vapor. Due to water vapor or reactions such as hydrolysis, the structure of the material is damaged. The humidity in the storage place should be maintained at 40% - 60%, which can be controlled by auxiliary means such as desiccant, such as lime, calcium chloride and other desiccants to absorb excess water vapor.
Furthermore, light is also a major factor. This substance is sensitive to light, and strong light irradiation or luminescent chemical reactions cause it to decompose or change its structure. Therefore, it needs to be stored in a light-shielding container or in a dark room to avoid light exposure.
In addition, the storage place should be well ventilated to avoid the accumulation of harmful gases and vapors, which may react chemically with the substance. And the storage place should be kept away from flammable and explosive materials such as fire sources and heat sources to prevent the risk of fire and explosion.
When storing 6-bromo-benzo [b] thiophene-2-carboxylic acid methyl ester, it is necessary to observe the principles of cool, dry, shading and ventilation, and keep away from fire sources to ensure the quality and safety of the substance, and to play its due effect in subsequent use.