6-bromo-4-fluoro-benzothiophene-2-carboxylic acid

6-Bromo-4-fluoro-benzothiophene-2-carboxylic acid, which is white to off-white crystalline powder. Its melting point is critical, about 230-235 ° C. In this temperature range, the substance will gradually change from solid to liquid state. This property is of great significance in many chemical operations involving temperature changes.
On solubility, it shows some solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide, which can be moderately dissolved, but has little solubility in water and is almost insoluble. This difference in solubility has a profound impact on the separation, purification and selection of reaction solvents. If the reaction is to be carried out efficiently in a homogeneous system, a solvent with good solubility needs to be selected.
Its stability is stable under normal environmental conditions. However, if exposed to strong light, high temperature or high humidity, its chemical structure may gradually change and degrade. Due to the existence of halogen atoms such as bromine and fluorine in the molecular structure, it has a certain chemical activity. Under specific reagents and conditions, it can participate in various chemical reactions such as substitution and condensation. It is widely used in the field of organic synthesis and can be used as a key intermediate to prepare organic compounds with more complex structures and more specific functions.

6-Bromo-4-fluoro-benzothiophene-2-carboxylic acid, this is an organic compound. It is acidic and contains a carboxyl group (-COOH), which can release hydrogen ions under appropriate conditions, neutralize with alkali substances, and generate corresponding salts and water.
In this compound, the presence of bromine (Br) and fluorine (F) atoms gives it unique properties. Halogen atoms are electronegative, which can affect the distribution of electron clouds in molecules, which in turn affects their physical and chemical properties. For example, it can enhance the polarity of molecules and affect their solubility. In chemical reactions, halogen atoms can participate in reactions such as nucleophilic substitution.
The structure of benzothiophene is a fused ring system with certain aromaticity, which makes the molecule relatively stable. However, this structure also makes it possible to perform aromatic reactions such as electrophilic substitution, and the reaction check point is affected by the positioning effect of bromine, fluorine and carboxyl groups.
Its chemical properties are active and can participate in a variety of organic synthesis reactions, such as esterification with alcohols under acid catalysis to form corresponding esters. It can also modify the substituents on the benzothiophene ring through a specific reaction path to prepare derivatives with different functions, which may have potential applications in pharmaceutical chemistry, materials science and other fields.

6-Bromo-4-fluoro-benzothiophene-2-carboxylic acid, an organic compound, has important uses in many fields.
First, in the field of medicinal chemistry, it is a key intermediate. It can be linked with other active groups through a series of reactions to construct compounds with specific pharmacological activities. In the process of many drug development, such intermediates containing bromine, fluorine and benzothiophene structures are required. Due to the introduction of bromine and fluorine atoms, the physical, chemical and biological activities of compounds can be significantly changed, such as regulating the lipophilicity and metabolic stability of compounds, so as to optimize the pharmacokinetic properties of drugs. For example, some novel drug molecular designs for the treatment of specific diseases use this compound as a starting material, modified and modified to obtain drugs with high affinity and selectivity for specific targets.
Second, in the field of materials science, 6-bromo-4-fluoro-benzothiophene-2-carboxylic acid is also valuable. Due to its unique molecular structure, it can be used to prepare organic optoelectronic materials. For example, in the synthesis of organic Light Emitting Diode (OLED) and organic solar cell materials, this compound can be used as a structural unit to participate in the construction of macromolecules with specific optoelectronic properties. The structure of benzothiophene endows the material with certain conjugation, and the presence of bromine and fluorine atoms can adjust the electron cloud distribution of the molecule, affect the energy level structure and charge transport performance of the material, and then improve the luminous efficiency of OLED or the photoelectric conversion efficiency of organic solar cells.
Third, in the field of organic synthetic chemistry, as an important synthetic block, it can participate in a variety of organic reactions, such as nucleophilic substitution reactions, coupling reactions, etc. Chemists can take advantage of the activity of bromine atoms to perform substitution reactions with various nucleophilic reagents and introduce different functional groups; at the same time, with the help of the special electronic effect of benzothiophene rings, some unique chemical transformations can be realized, providing an effective way for the construction of complex organic molecular structures and promoting the development of organic synthetic chemistry.

The synthesis of 6-bromo-4-fluoro-benzothiophene-2-carboxylic acid is one of the key topics in organic synthetic chemistry. The synthesis method has been described in many books in the past, and it is now detailed by you.
One method uses compounds containing benzene ring and sulfur atoms as starting materials, and introduces bromine atoms at specific positions in the benzene ring first. This step may be achieved by bromination reaction. Commonly used brominating reagents, such as liquid bromine, N-bromosuccinimide (NBS), etc. When reacting, pay attention to the control of reaction conditions, such as temperature and solvent selection. Using NBS as a brominating agent, in a suitable organic solvent, such as carbon tetrachloride, under the action of an initiator such as benzoyl peroxide, bromine atoms can be selectively attached to specific positions in the benzene ring.
Then, in another step, fluorine atoms are introduced. The method of introducing fluorine atoms is commonly used for nucleophilic substitution reactions. Fluorine-containing reagents, such as potassium fluoride, can be selected. In the presence of a phase transfer catalyst, in a suitable solvent, such as dimethyl sulfoxide (DMSO), the fluorine atom replaces the specific group on the benzene ring, thereby achieving the introduction of fluorine atoms.
After both bromine and fluorine atoms are introduced, the benzothiophene ring is constructed. This step often requires the help of specific organic reactions, such as intramolecular cyclization reactions. Or the reactivity between sulfur atoms and specific groups on the benzene ring can be used to cyclize the molecule under appropriate reaction conditions to form a benzothiophene structure.
As for the introduction of carboxyl groups, it can be obtained by oxidation of benzothiophene derivatives. For example, with a strong oxidant such as potassium permanganate, under suitable reaction conditions, a specific side chain on the benzothiophene ring is oxidized to a carboxyl group, resulting in 6-bromo-4-fluoro-benzothiophene-2-carboxylic acid. < Br >
Synthesis requires detailed observation of the conditions of each step of the reaction, precise control, and the ideal product can be obtained, and the yield and purity can be improved. This is the general route for the synthesis of 6-bromo-4-fluoro-benzothiophene-2-carboxylic acid.

6-Bromo-4-fluoro-benzothiophene-2-carboxylic acid, this product is in the market, what is its price? I don't know the market, but I can make a brief guess based on past experience and the price of similar products.
This compound belongs to the category of fine chemicals, and its synthesis may require multiple steps, and the raw materials and processes will affect its price. If the raw materials are easily available, the synthesis process is not complicated, and the price may be slightly lower; on the contrary, if the raw materials are scarce and the preparation steps are complicated, the price will be high.
In the chemical market, the price of such halogenated and heterocyclic carboxylic acids varies depending on purity and batch size. If it is of ordinary purity and the batch is large, the price per gram may be around tens to hundreds of yuan. However, if you pursue high purity, such as for high-end fields such as pharmaceutical research and development, the purity reaches more than 98%, and the price may climb to hundreds of yuan per gram.
In addition, market supply and demand also determine its price. If there are many people who want it, but there are few products, the price will rise; if supply exceeds demand, the price may be lowered.
In summary, the market price of 6-bromo-4-fluoro-benzothiophene-2-carboxylic acid is about tens to hundreds of yuan per gram, but this is only a rough guess. The actual price shall be subject to the quotation of each supplier.