5-Nitrothiophene-2-carbonitrile

5-Nitrothiophene-2-formonitrile is also an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
In the process of pharmaceutical creation, 5-nitrothiophene-2-formonitrile can be used as a starting material. After many chemical reactions, complex compounds with complex structures can be derived, many of which may have pharmacological activity and can be used to develop new drugs to treat various diseases.
In the field of materials science, it can participate in the synthesis of special functional materials. Due to the unique electronic properties of the thiophene structure, 5-nitrothiophene-2-formonitrile is introduced into specific materials, which may endow materials with special properties such as good electrical conductivity and optical properties, making it suitable for the preparation of electronic devices, optoelectronic devices and other materials.
In the field of pesticides, 5-nitrothiophene-2-formonitrile may be chemically modified to create new pesticides. Such pesticides may have the ability to effectively suppress and kill specific pests and pathogens, and may have lower toxicity and more environmentally friendly characteristics than traditional pesticides, providing a new path for agricultural pest control.
In addition, in the synthesis of dyes, 5-nitrothiophene-2-formonitrile can contribute a unique structure, making the synthesized dyes have excellent color fastness, bright color and other characteristics, and are used in textile, printing and dyeing industries.
In summary, 5-nitrothiophene-2-formonitrile has important uses in many fields such as medicine, materials, pesticides, dyes, etc., providing an important foundation and assistance for the development of related fields.

5-Nitrothiophene-2-carbonitrile is an important compound in the field of organic synthesis. There are many synthesis methods, which are described in detail below.
First, 2-thiophenecarboxylic acid is used as the starting material. First, 2-thiophenecarboxylic acid is co-heated with thionyl chloride to obtain 2-thiophenecarboxylic chloride. This reaction needs to be controlled by temperature to prevent side reactions. Subsequently, 2-thiophenecarboxylic acid chloride reacts with sodium cyanide in a suitable solvent to obtain 2-thiophenecarboxylate. 5-Nitrothiophene-2-carbonitrile is obtained by nitrifying 2-thiophene acetonitrile with a mixed acid composed of concentrated nitric acid and concentrated sulfuric acid. In this route, the conditions of the nitrification step are quite critical, and the ratio of mixed acid, reaction temperature and time all affect the yield and purity of the product.
Second, start from 2-bromothiophene. 2-bromothiophene is first heated with zinc powder and cuprous cyanide, and the bromine atom is replaced by a cyanyl group to obtain 2-cyanothiophene. This reaction requires inert gas protection to ensure the purity of the reaction environment. Then, 2-cyanothiophene is nitrified with a mixed acid of fuming nitric acid and concentrated sulfuric acid to obtain the target product. In this process, the concentration and dosage of fuming nitric acid, as well as the reaction temperature, need to be carefully adjusted to avoid excessive nitrification.
Third, thiophene is used as the initial product. Thiophene is first introduced into the formyl group through the Vilsmeier-Haack reaction to obtain 2-thiophene formaldehyde. This reaction requires a specific reaction solvent and acid binding agent. 2-Thiophene formaldehyde is then reacted with hydroxylamine hydrochloride to obtain 2-thiophene methoxime, and then dehydrated under appropriate conditions to obtain 2-thiophenonitrile. Finally, 2-thiophenonitrile is nitrified to obtain 5-Nitrothiophene-2-carbonitrile. Although there are many steps in this route, the reaction conditions of each step are relatively mild, so the product separation and purification of each step cannot be ignored, otherwise the quality of the final product will be affected.
All synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider the availability of raw materials, cost, product purity and other factors, and choose an appropriate method to achieve efficient synthesis of 5-Nitrothiophene-2-carbonitrile.

5-Nitrothiophene-2-formonitrile is also an organic compound. Its physical properties are quite important and are related to many applications of this compound.
First of all, its appearance, at room temperature, 5-nitrothiophene-2-formonitrile is mostly a light yellow to yellow crystalline powder, and its color and state are easy to identify and distinguish from others.
and melting point, the melting point of this compound is about 105-109 ℃. The melting point is the inherent property of the substance and can be a key indicator when identifying and purifying. When heated to this temperature range, 5-nitrothiophene-2-formonitrile melts from the solid state to the liquid state. This property is very important in chemical production, drug preparation and other processes, involving the phase transition of substances.
Besides solubility, 5-nitrothiophene-2-formonitrile is slightly soluble in water, but it has good solubility in organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF). This difference in solubility is of great significance when separating, extracting, and selecting the reaction solvent. For example, if you want to separate this compound from an impurity mixture that is insoluble in an organic solvent, its solubility in an organic solvent can be used to achieve effective separation.
Its density is also an important physical property. Although the exact value varies slightly due to the measurement conditions, roughly speaking, there is a certain density range. Knowledge of density can help engineers plan the volume of the reactor and the amount of material to be delivered in chemical design, material balance calculation, etc.
In addition, the stability of 5-nitrothiophene-2-formonitrile also needs attention. Under normal conditions, it is relatively stable. However, under extreme conditions such as strong oxidizing agents, strong acids, and strong bases, or chemical reactions may occur, resulting in changes in structure and properties. When storing and using, it must be properly stored and operated according to its stability characteristics to prevent danger and deterioration.

5-Nitrothiophene-2-formonitrile, this is an organic compound. Its chemical properties are unique, let me talk about them one by one.
First of all, its stability. There are nitro groups and nitrile groups in the structure of 5-nitrothiophene-2-formonitrile, which have a great impact on the stability of compounds. Nitro groups have strong electron absorption, which can change the density distribution of molecular electron clouds, making them relatively stable. However, under certain conditions, such as high temperature and strong acid-base environment, the stability will be challenged. At high temperature, the nitro group may decompose, causing molecular structure changes.
Let's talk about its reactivity. Nitrile groups can undergo a variety of reactions. During hydrolysis, under the catalysis of acid or base, the nitrile group can be converted into a carboxyl group to form 5-nitrothiophene-2-carboxylic acid. This reaction is an important path for the preparation of carboxyl-containing thiophene derivatives. Nucleophilic addition reactions can also occur with nucleophiles, such as with alcohols under the action of catalysts to form imide esters.
The reactivity of nitro groups cannot be ignored. Nitro groups can be reduced, and common reduction methods include catalytic hydrogenation and chemical reduction. After reduction, nitro groups are converted into amino groups to obtain 5-aminothiophene-2-formonitrile. Amino is a strong donator group, which can significantly change the electron cloud density of thiophene rings, thereby affecting the reactivity and properties of compounds, laying the foundation for subsequent derivatization reactions. 5-Nitrothiophene-2-formonitrile has wide application potential in the field of organic synthesis because of its nitro and nitrile groups. It can be converted into different functional compounds through various reactions.

What is the price of 5-nitrothiophene-2-formonitrile in the market? This is a product in the field of fine chemical raw materials. However, it is not easy to know the exact market value of it.
Because the price in the city is often affected by various factors. First, the situation of supply and demand is also. If there are many people who want it, and the supply is small, the price will rise; conversely, if the supply exceeds the demand, the price may fall. Second, the price of raw materials is also the main reason. The production of 5-nitrothiophene-2-formonitrile requires specific raw materials, and the price of raw materials fluctuates, and the price of finished products also changes. Third, the manufacturing cost, including the simplicity of the production process, the amount of energy consumption, labor costs, etc., will affect its final selling price. Fourth, the state of market competition, fierce competition among peers, in order to compete for share, there may be price cuts; if there is no strong competitor, the price may be stable and high.
And the market conditions in various places are also different. Prosperous places, demand may be prosperous, prices may be different; remote places, supply and demand are different, prices are also different. To know the exact price, you need to check the chemical raw material trading platform, consult chemical product suppliers, or refer to professional market survey reports to get a more accurate number.