5-methylthiophene-2-carboxylate

5-Methylthiophene-2-carboxylate, a member of the family of organic compounds. Its molecular structure contains a thiophene ring, which is connected to a methyl group at the 5th position and a carboxylate group at the 2nd position. The chemical properties of this compound are interesting and unique.
Discussing the physical properties, under normal circumstances, 5-methylthiophene-2-carboxylate exists in a solid state, mostly crystalline, with a certain melting point. This melting point varies slightly depending on the specific type of carboxylate, but it is roughly within a certain temperature range. Its solubility in organic solvents is also related to the structure of the carboxylate. In general, in polar organic solvents, such as methanol, ethanol, and acetone, there is moderate solubility, while in non-polar solvents, such as n-hexane and benzene, the solubility is poor.
From the perspective of chemical activity, the thiophene ring of 5-methylthiophene-2-carboxylate exhibits aromatic properties, allowing it to participate in typical reactions of many aromatic compounds. For example, electrophilic substitution reactions can be carried out, and other functional groups can be introduced into the thiophene ring under appropriate conditions. Methyl attachment to the 5 position of the thiophene ring affects the density distribution of the ring electron cloud, which in turn affects the check point selectivity of the electrophilic substitution reaction. The carboxylate group imparts certain hydrophilicity to the compound and can participate in acid-base reactions. When encountering strong acids, carboxylic salts can be converted into carboxylic acids; when reacting with metal ions, different metal salts can be formed. This property is quite useful in the synthesis of specific metal complexes or organic-inorganic hybrid materials.
In addition, the conjugated structure of 5-methylthiophene-2-carboxylate has potential applications in the fields of optics and electricity. Due to its high degree of delocalization of intra-molecular electrons, it may exhibit unique photophysical and electrochemical properties, such as absorbing and emitting light of specific wavelengths, or redox reactions on the electrode surface. These properties lay the foundation for its application in organic optoelectronic devices, such as organic Light Emitting Diodes, solar cells, and other fields.

5-Methylthiophene-2-carboxylate is an important compound in organic chemistry. In the field of chemical industry and scientific research, there are many ways to prepare and use it.
First, the corresponding thiophene derivative is used as the starting material, and this compound can be synthesized through a series of specific chemical reactions, such as halogenation and carboxylation. During halogenation, precise selection of halogenating reagents and reaction conditions is crucial, which is related to the purity and yield of the product. The carboxylation step also needs to be carefully regulated to achieve the desired reaction effect.
Second, with the help of specific catalysts, the reaction can be carried out more efficiently. An excellent catalyst can not only speed up the reaction rate, but also improve the selectivity of the product and reduce the occurrence of side reactions. However, the selection of an appropriate catalyst requires comprehensive consideration of the characteristics, cost and environmental factors of the reaction system.
Furthermore, in terms of organic synthesis path design, it is necessary to carefully plan according to the existing raw materials and reaction conditions. Or use a multi-step reaction strategy to gradually construct the target molecular structure. Each step of the reaction needs to be carefully controlled to ensure the purity and stability of the intermediate product, so as to lay a good foundation for the subsequent reaction.
In addition, in actual operation, many factors such as reaction temperature, time, and the proportion of reactants all have a significant impact on the quality and yield of the product. Therefore, in the experimental process, it is necessary to explore and optimize these conditions carefully in order to obtain the best synthetic effect.
In short, the preparation and use of 5-methylthiophene-2-carboxylate requires comprehensive consideration of many factors, careful design and operation, in order to achieve the desired purpose and play its due role in organic synthesis and related fields.

To prepare 5-methylthiophene-2-carboxylate, the following method can be followed.
First, thiophene is taken as the starting material. After bromination, thiophene interacts with bromine under specific conditions, and bromine atoms are introduced into the thiophene ring. The brominating reagent used, such as bromine, undergoes electrophilic substitution with thiophene under an appropriate catalyst, such as iron powder or iron tribromide, to mainly generate 2-bromothiophene. This step requires controlling the reaction temperature and the proportion of materials to increase the yield of the target product. After 2-bromothiophene is obtained, 2-bromothiophene is methylated to react with a methylating agent, such as methyl lithium or iodomethane, in an appropriate solvent, such as anhydrous ether or tetrahydrofuran, to introduce methyl into the fifth position of the thiophene ring to generate 5-methyl-2-bromothiophene. This reaction requires strict anhydrous conditions in the reaction environment to prevent the methylating agent from failing in contact with water.
5-methyl-2-bromothiophene is carboxylated again, and 5-methyl-2-thiophene magnesium bromide can be prepared with metal magnesium first. Anhydrous ether or tetrahydrofuran as solvent is prepared at low temperature and anhydrous and anaerobic environment. After that, carbon dioxide gas is introduced, and the Grignard reagent undergoes nucleophilic addition reaction with carbon dioxide to generate 5-methylthiophene-2-carboxylic acid intermediate.
Finally, 5-methylthiophene-2-carboxylic acid reacts with appropriate bases, such as sodium hydroxide and potassium hydroxide, in aqueous solution, and the acid and base are neutralized to obtain 5-methylthiophene-2-carboxylate. After the reaction is completed, the pure 5-methylthiophene-2-carboxylate product can be obtained through separation and purification methods, such as extraction and recrystallization. The whole synthesis process requires fine operation and strict control of the reaction conditions at each step to obtain satisfactory results.

5-Methylthiophene-2-carboxylic acid ester, the price of this product in the market is difficult to determine. The change in its price is affected by various factors.
First, the source of the material. If the various raw materials required for its preparation are easy and sufficient, the price will be flat; however, if the raw materials are thin and difficult to find, the price will be high.
Second, the simplicity of the process. If the preparation method is simple, the labor cost is saved, and the price is also low; if the process is complicated, the exquisite technology is required, and the manpower and material resources are expended, the price will be high.
Furthermore, the supply and demand of the city. If there are many applicants and few suppliers, the price will rise; if the supply exceeds the demand, the price will drop.
In addition, the difference in origin also has an impact. In different places, the price may vary due to taxes, freight, etc.
According to past market conditions, the price of 5-methylthiophene-2-carboxylic acid ester fluctuates from a few yuan to several hundred yuan per gram. If it is an ordinary quality, when the supply is abundant and the demand is normal, it may cost tens of yuan per gram. However, if it is a high purity, special grade, and the needs of specific industries, such as fine chemicals, pharmaceutical research and development, etc., and the supply is scarce in the market, the price may reach several hundred yuan per gram. < Br >
However, the market situation is changing like a cloud, and to know the exact price, you need to consult chemical raw material suppliers, reagent suppliers, or observe the real-time market conditions of chemical product trading platforms to obtain accurate figures.

There are several manufacturers of 5-methylthiophene-2-carboxylic acid ester in the world today. However, I have searched for ancient classics, but it seems that I have not obtained an exhaustive list. However, as far as I know of the chemical industry, many manufacturers have the ability to produce these compounds.
In China, there are many chemical companies involved in the production of this compound. For example, some manufacturers focusing on fine chemicals often produce various high-quality chemicals with exquisite skills and advanced equipment, and 5-methylthiophene-2-carboxylic acid ester is one of them. With their deep technical accumulation, they are unique in controlling reaction conditions and improving purification processes to ensure high product quality.
There are also many chemical giants overseas, with outstanding R & D and capacity. They may have advanced scientific research teams, constantly exploring and optimizing production processes, and are committed to improving product performance. In the international chemical market, their products may have a high reputation and market share, and 5-methylthiophene-2-carboxylate may also be a corner of their product line.
However, if you want a detailed and accurate list of 5-methylthiophene-2-carboxylate manufacturers, you need to go into the chemical information library, industry exhibition materials, or consult chemical professionals to obtain detailed information. Although I cannot list the names of the manufacturers one by one, according to the state of the chemical industry, if you look for a manufacturer of this product, you can explore it in the context of fine chemicals and organic synthesis, and you will definitely find something.