5 Methylthiophene 2 Carbaldehyde
quinoline thiophene imidazole thiazole

5-methylthiophene-2-carbaldehyde

Taiy Chemical

    Specifications

    HS Code

    453787

    Chemical Formula C6H6OS
    Molecular Weight 126.176 g/mol
    Appearance Liquid (usually)
    Color Yellow - brownish
    Odor Characteristic
    Density Approx. 1.18 g/cm³
    Boiling Point Around 190 - 195 °C
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether

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    General Information
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    Frequently Asked Questions

    As a leading 5-methylthiophene-2-carbaldehyde supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the chemistry of 5-methylthiophene-2-carbaldehyde?
    5-Methylthiophene-2-formaldehyde, an organic compound, has unique chemical properties. Its appearance may be liquid, solid, colorless, or microstrip color, depending on the purity and preparation method.
    In terms of chemical activity, the aldehyde group in the molecule is active and can participate in a variety of reactions. One is oxidation reaction. Under the action of suitable oxidants, the aldehyde group is easily oxidized to carboxyl groups to generate 5-methylthiophene-2-carboxylic acid. This reaction is often used in organic synthesis to construct carboxyl functional groups to prepare compounds with specific structures.
    The second is a reduction reaction. The aldehyde group can be reduced to a hydroxyl group to generate 5-methyl-2- (hydroxymethyl) thiophene. Commonly used reducing agents such as sodium borohydride, lithium aluminum hydride, etc. This reaction provides a path for obtaining hydroxyl-containing organic compounds.
    The third is a nucleophilic addition reaction. The carbon and oxygen double bond of the aldehyde group attracts the attack of the nucleophilic reagent and causes addition. For example, when reacted with alcohols, acetals are formed under acid catalysis. This reaction can be used to protect the aldehyde group from being affected in subsequent reactions. After the reaction is completed, the aldehyde group is deprotected under specific conditions to restore the aldehyde group.
    In addition, the thiophene ring imparts special electronic effects and aromaticity to the compound. The π electron cloud distribution of thiophene ring affects the molecular stability and reactivity, and it can participate in the aromatic electrophilic substitution reaction, introduce other functional groups on thiophene ring, enrich the structure and properties of compounds, and expand its application in materials science, medicinal chemistry and other fields.
    5-methylthiophene-2-formaldehyde has rich chemical properties, providing various possibilities for organic synthesis and related fields research, and has potential application value in materials, medicine and many other fields.
    What are the main uses of 5-methylthiophene-2-carbaldehyde?
    5-Methylthiophene-2-formaldehyde is an important chemical substance in organic synthesis. It has a wide range of uses and is often a key intermediate in the synthesis of many drugs in the field of medicinal chemistry. The special structure of genthiophene and aldehyde groups can be used to construct complex drug molecular structures through various chemical reactions, such as for the synthesis of antibacterial and anti-inflammatory drugs with specific biological activities.
    In the field of materials science, it also plays an important role. It can participate in the preparation of functional polymer materials through chemical reactions. For example, by polymerizing with specific monomers, the material is endowed with unique photoelectric properties, which has great potential in the research and development of organic Light Emitting Diode (OLED), solar cells and other materials.
    Furthermore, in the field of fragrance chemistry, 5-methylthiophene-2-formaldehyde also has its uses. Due to its special molecular structure, it can be converted into compounds with unique aromas through chemical reactions, providing the possibility for the formulation of novel fragrances, and has applications in perfume, food additives and other industries.
    In addition, in the field of fine chemicals, it is often used as a starting material for the synthesis of fine chemicals. Through various functional group conversion reactions, a series of high-value-added fine chemicals can be prepared to meet the needs of different industries and scientific research.
    In summary, 5-methylthiophene-2-formaldehyde has important uses in many fields such as medicine, materials, flavors and fine chemicals, and has made great contributions to the development of various fields.
    What are 5-methylthiophene-2-carbaldehyde synthesis methods?
    The synthesis method of 5-methylthiophene-2-formaldehyde is discussed in detail today.
    First, thiophene is used as the initial raw material. Under appropriate reaction conditions, thiophene is methylated with methylating reagents such as iodomethane under the catalysis of bases, and methyl is introduced into the 5-position of the thiophene ring to generate 5-methylthiophene. Subsequently, 5-methylthiophene and suitable formylation reagents, such as N, N-dimethylformamide (DMF) and phosphorus oxychloride (POCl
    ), at a suitable temperature and reaction time, a formylation reaction occurs, and a formyl group is introduced at the 2-position to obtain 5-methylthiophene-2-formaldehyde. This method step is relatively clear, but the reaction conditions need to be precisely controlled. The formylation step may have side reactions that affect the purity and yield of the product.
    Second, it can be started from 2-bromo-5-methylthiophene. 2-Bromo-5-methylthiophene is reacted with metal magnesium to make Grignard reagent, that is, 2- (5-methylthiophenyl) magnesium bromide. After that, the Grignard reagent reacts with N, N-dimethylformamide, and after hydrolysis, 5-methylthiophene-2-formaldehyde can be obtained. This way takes advantage of the activity of Grignard reagent, and the reaction is relatively efficient. However, the preparation process of Grignard reagent requires an anhydrous and oxygen-free environment, which requires quite high operation requirements. A little carelessness can easily cause the reaction to fail.
    Third, 5-methyl-2-acetylthiophene is used as raw material. Acetyl groups can be converted to formyl groups by selective oxidation. For example, using mild oxidizing agents such as active manganese dioxide, etc., under suitable organic solvents and reaction temperatures, this oxidation conversion is achieved to obtain the target product 5-methylthiophene-2-formaldehyde. The advantage of this method is that the reaction conditions are relatively mild and the selectivity is good, but the amount of oxidizing agent and reaction time need to be carefully optimized to achieve the best reaction effect.
    What 5-methylthiophene-2-carbaldehyde need to pay attention to when storing and transporting
    5-Methylthiophene-2-formaldehyde is an organic compound. When storing and transporting, many key matters need to be paid attention to.
    Bear the brunt, and the storage place must be cool, dry and well ventilated. Because of its volatility, high temperature, humidity or poorly ventilated environment, it is easy to increase its volatilization, or even cause deterioration. For example, if placed in a hot and humid place, it may react with water vapor and other components in the air, affecting its quality.
    Furthermore, it is necessary to strictly keep away from fire sources and oxidants. The compound is flammable, and it is easy to burn when exposed to open flames and hot topics. Contact with oxidants is likely to trigger violent chemical reactions, resulting in serious accidents such as fire or explosion.
    When storing, the package should also be tightly sealed. Avoid long-term contact with air to prevent oxidation. Choose suitable packaging materials, such as glass bottles, metal drums, etc., to ensure that it can effectively isolate external factors.
    During transportation, the environment should also be maintained. Vehicles should have good ventilation conditions, and the transportation temperature should be controlled within a certain range. Be careful when loading and unloading to prevent package damage. If the package is damaged, it will not only leak 5-methylthiophene-2-formaldehyde, pollute the environment, but also cause danger due to contact with external substances.
    In addition, whether it is storage or transportation, it is necessary to follow relevant regulations and standards, and equip corresponding emergency treatment equipment and protective equipment for emergencies. In this way, the safety of 5-methylthiophene-2-formaldehyde during storage and transportation can be ensured, and accidents can be avoided.
    What is the market outlook for 5-methylthiophene-2-carbaldehyde?
    5-Methylthiophene-2-formaldehyde, which is in the market, is worth exploring in the future. Looking at the fields of chemical industry, its use is becoming more and more extensive, and the prospect may be booming.
    In the field of pharmaceutical chemistry, 5-methylthiophene-2-formaldehyde is often the key raw material for synthesizing wonderful medicines. At present, the research and development of medicine is booming, and there is a constant need for novel raw materials. Based on this substance, a variety of special drugs can be prepared, such as antibacterial and antiviral agents. With the daily advancement of medical technology, the demand for it may arrive like a river, and the market capacity is expected to gradually expand.
    In the field of materials science, it has also emerged. Or can participate in the synthesis of special polymer materials, endowing the material with specific properties, such as better stability and conductivity. Today's innovation in the field of materials has surged, and the demand for materials with unique properties has surged. 5-methylthiophene-2-formaldehyde has gained opportunities and may occupy a place in the relevant market.
    However, its market prospects are not entirely cloudy. First, the synthesis method may be complicated and costly. If the preparation technology is difficult to improve and the cost remains high, it will hinder market expansion. Second, competition in the same industry is also an inevitable factor. As the future of this product gradually becomes clear, various manufacturers may come one after another, and competition will be fierce. If the company does not have unique advantages, such as excellent technology and cost leadership, it may be difficult to stand out.
    Although 5-methylthiophene-2-formaldehyde faces the challenge of cost and competition, it still has a considerable market prospect driven by demand in fields such as medicine and materials. If technological innovation and cost control are effective, it will make a difference in the market.