5-(Hydroxymethyl)thiophene-2-boronic aicd

5- (hydroxymethyl) thiophene-2-boronic acid, this is a special compound in organic chemistry. It has unique chemical properties and has made great contributions to the development of organic synthetic chemistry.
From the structural point of view, the compound has a thiophene ring as the core, with hydroxymethyl groups at the 5th position and boric acid groups at the 2nd position. This structure gives it a variety of reactivity.
In terms of reactivity, boric acid groups are active and can participate in many classical organic reactions, such as the Suzuki-Miyaura coupling reaction. In such reactions, boric acid groups and organic halides can form new carbon-carbon bonds under the action of palladium catalysts and bases, which is of great significance for the construction of complex organic molecular structures, which can be used to synthesize organic materials with specific structures and functions, pharmaceutical intermediates, etc. The presence of
hydroxymethyl groups also adds different reaction possibilities for this compound. Hydroxymethyl groups are nucleophilic and can participate in esterification, etherification and other reactions. For example, by reacting with carboxylic acids to form esters and halogenated hydrocarbons to form ethers, compounds can be structurally modified to expand their applications in different fields. Due to its unique structure, 5- (hydroxymethyl) thiophene-2-boronic acid exhibits active reactivity and is widely used in the field of organic synthesis, providing an effective way for the preparation of various functional organic compounds. It plays an important role in the development of materials science, medicinal chemistry and many other disciplines.

The common synthesis methods of 5- (hydroxymethyl) thiophene-2-boronic acid generally include the following.
First, thiophene is used as the starting material. First, thiophene is brominated, so that bromine atoms replace hydrogen atoms at specific positions of thiophene to obtain bromothiophene. This process requires careful control of the reaction conditions, such as reaction temperature and bromine dosage, to avoid unnecessary by-products. Next, bromothiophene interacts with metallic magnesium to form Grignard reagents. Grignard reagents are highly active and must be isolated from water vapor and air during preparation to prevent their inactivation. Then the Grignard reagent is reacted with borate esters, and after hydrolysis, 5- (hydroxymethyl) thiophene-2-boronic acid can be obtained. This path step is slightly complicated, but the raw material is easy to obtain, which is a common method.
Second, suitable thiophene derivatives can be selected, which already have some structural fragments of the target molecule. By modifying and transforming the specific functional groups of the derivatives, in order to achieve the purpose of synthesis. Such as a thiophene derivative, which contains groups that can be converted into hydroxymethyl groups, and a check point that can introduce boric acid groups. First, the convertible groups are processed, and they are converted into hydroxymethyl groups by suitable reagents and conditions. Subsequently, a boric acid group is introduced at a specific position of the thiophene in a suitable reaction. This method requires precise design of the structure of the starting derivative, and requires high selectivity for each step of the reaction.
Third, it is based on metal catalytic coupling reaction. Compounds containing thiophene structure with suitable leaving groups are selected to couple with reagents containing hydroxymethyl and boric acid precursors under the action of metal catalysts. In this process, the selection of metal catalysts is crucial, and its activity and selectivity directly affect the success or failure of the reaction and the yield. At the same time, the ligand, base and other conditions in the reaction system also need to be finely regulated to promote the reaction to proceed efficiently and selectively, so as to obtain the target product 5- (hydroxymethyl) thiophene-2-boronic acid.

5- (hydroxymethyl) thiophene-2-boronic acid, which is useful in many fields. In the field of medicinal chemistry, it is a key building block for the synthesis of new drugs. Due to the structural characteristics of thiophene and boric acid, drugs can be endowed with unique activity and selectivity. For example, when developing anti-tumor drugs, compounds constructed from this raw material may act precisely on tumor cell targets, and interact with specific proteins or enzymes through their borate groups, interfering with the growth and proliferation of tumor cells.
In the field of materials science, it has also emerged. In the preparation of organic optoelectronic materials, it can be introduced into polymer systems as functional monomers. The thiophene unit endows the material with good electron transport properties, while the boric acid group can participate in the crosslinking reaction to improve the stability and mechanical properties of the material. The prepared material may be used in organic Light Emitting Diode (OLED), solar cells and other devices to improve its photoelectric conversion efficiency and service life.
In the field of organic synthesis, 5- (hydroxymethyl) thiophene-2-boronic acid is a powerful tool for constructing complex organic molecules. With its reactivity of boric acid groups, it can participate in a variety of classic organic reactions, such as Suzuki-Miyaura coupling reaction. Through this reaction, thiophene derivatives can be coupled with other aryl halides to form a diverse conjugate system, which opens up a way for the synthesis of organic compounds with special structures and properties, and then plays an important role in the total synthesis of natural products and the synthesis of new ligands.

What you are inquiring about is the market price of 5- (hydroxymethyl) thiophene-2-boronic acid. However, this price is not fixed and often changes due to various factors.
First, it is difficult to prepare. If the synthesis method is complicated, the required raw materials are rare and expensive, or the preparation process consumes a lot of energy and the steps are cumbersome, the price will be high.
Second, the state of supply and demand. If the market has a strong demand for this product and the supply is limited, if only a few workshops can produce it, and the output is not abundant, the price will also increase; conversely, if the supply exceeds the demand, the price will drop.
Third, the difference in quality. High quality, less impurities, high purity, suitable for high-end scientific research, pharmaceutical and other fields, and its price is higher than that of ordinary quality.
Fourth, the difference in region. Different places have different prices due to transportation costs, tax policies, and market environments. In prosperous cities, the demand is large and the cost is high, and the price may be slightly more expensive; in remote places, if there is no convenient transportation and wide demand, the price may be slightly lower.
As far as I know, the price of this product in the market may be between tens of yuan and hundreds of yuan per gram. However, this is only an approximation. The actual price should be obtained by consulting chemical raw material suppliers and reagent sellers in detail. If you need to buy this item, you can ask a few more to compare its price, quality, and service before making a decision.

5- (hydroxymethyl) thiophene-2-boronic acid should be stored in a cool and dry place, away from water, fire and strong acid and alkali. This material is delicate, hot and changeable, and damp. Therefore, when placed in a low temperature place, the temperature should not exceed 20 degrees Celsius, and the air must be dry, and the humidity should not exceed 60%.
And because it is flammable in case of fire, it is easy to react in water, and it encounters strong acids and alkalis, or changes violently, so it is far away from all fire sources and water sources, and it should not be placed in the same place as strong acids and alkalis.
When storing, it is advisable to use a sealed device to prevent it from being too much in contact with the air and causing the composition to be changed. When using it, we should also be cautious and follow the procedures to ensure its purity and stability, so that it can be retained for a long time for future use.