5-Formylthiophene-2-carbonitrile

5-formylthiophene-2-formonitrile, this is an organic compound. It has special chemical properties. Its structure contains a thiophene ring, which is connected to a formyl group and a formonitrile group, which give it unique reactivity.
In terms of electrophilicity, the carbon atom of the carbon-oxygen double bond in the formyl group is positively charged and vulnerable to attack by nucleophiles. Common nucleophiles such as alcohols and amines can undergo nucleophilic addition reactions with formyl groups. For example, under acid catalysis with alcohols, acetals can be formed. This reaction is often used as a means of carbonyl protection in organic synthesis. < Br >
The formonitrile group is also reactive and can be hydrolyzed. Under the catalysis of acid or base, it is converted into a carboxyl group or an amide group. When catalyzed by base, the amide intermediate is formed, and the carboxylic acid is further hydrolyzed. In addition, the formonitrile group can participate in the nucleophilic substitution reaction, providing the possibility for the construction of new carbon-carbon or carbon-heteroatomic bonds.
Due to the aromatic properties of thiophene rings, this compound also exhibits certain aromatic properties. The electrophilic substitution reaction can occur, and the formyl group and the formonitrile group are electron-withdrawing groups, which will reduce the electron cloud density of the thiophene ring, and the electrophilic substitution reaction activity is slightly lower than that of the thiophene itself. The substitution position tends to be relatively high in the electron cloud density of the thiophene ring.
Its physical properties, in view of the polar group, have a certain solubility in common organic solvents such as dichloromethane and chloroform, but there is a certain force between molecules, and the melting point and boiling point are relatively high. In short, the chemical properties of 5-formylthiophene-2-formonitrile make it potentially valuable in organic synthesis, pharmaceutical chemistry and other fields.

There are several common methods for the synthesis of 5-formylthiophene-2-formonitrile. First, the thiophene group is introduced into the formyl group before the specific position of the thiophene, which can be obtained through the Vilsmeier-Haack reaction. In this reaction, thiophene is co-heated with N, N-dimethylformamide (DMF) and phosphorus oxychloride (POCl). After electrophilic substitution, a formyl group is introduced at the 2-position of the thiophene ring, and then a suitable cyanide agent, such as cuprous cyanide (CuCN), is introduced into the cyanyl group at the ortho-position of the formyl group under specific conditions, resulting in 5-formylthiophene-2-formonitrile.
Second, starting from 2-methylthiophene. First, the methyl of 2-methylthiophene is oxidized to an aldehyde group in a suitable solvent with a mild oxidizing agent, such as manganese dioxide (MnO _ 2) or active manganese dioxide, to obtain 2-formylthiophene. Subsequently, halogen atoms are introduced at the 5-position of the thiophene ring through halogenation reaction, and bromine (Br _ 2) or N-bromosuccinimide (NBS) are commonly used. Then, the target product can also be obtained by cyanide substitution with cyanide reagents, such as potassium cyanide (KCN) or sodium cyanide (NaCN), through nucleophilic substitution.
Third, cross-coupling reaction catalyzed by palladium. In the presence of a palladium catalyst, such as tetra (triphenylphosphine) palladium (Pd (PPh)), and a base, the halogen atom of the halide is cross-coupled with the active group of the organometallic reagent to form a carbon-carbon bond, thus forming 5-formylthiophene-2-formonitrile. Each method has its own advantages and disadvantages, and the choice needs to be made carefully according to the actual situation, such as the availability of raw materials, reaction conditions, product purity, etc.

5-formylthiophene-2-formonitrile is an organic compound. It has its extraordinary uses in many fields.
In the field of pharmaceutical creation, its function is significant. Because of its specific chemical structure, it can be used as a key intermediate to assist in the synthesis of other biologically active compounds. For example, when developing antibacterial, antiviral and anti-tumor drugs, 5-formylthiophene-2-formonitrile may be chemically modified to derive components that can precisely act on diseased cells for the purpose of treating diseases.
In the field of materials science, it also has its uses. It may be involved in the preparation of optoelectronic materials. The cover may give the material unique optical and electrical properties due to its chemical properties. The resulting material may be applied to organic Light Emitting Diode (OLED), solar cells and other devices to improve the performance of such devices, such as enhancing luminous efficiency, improving photoelectric conversion rate, etc.
In agricultural chemistry, it is also indispensable. It can be synthesized through a series of reactions with insecticidal, bactericidal or herbicidal effects. The pesticides based on it may have the characteristics of high efficiency, low toxicity and environmental friendliness, which can not only effectively control crop diseases and pests, but also reduce the adverse impact on the environment and help the sustainable development of agriculture.
In addition, in the field of organic synthetic chemistry, it is a commonly used synthetic block. Chemists can perform various reactions on it, such as nucleophilic addition, cyclization reaction, etc., to construct more complex and diverse organic molecules, expand the types of organic compounds, and provide rich materials for the research and development of organic chemistry. In short, 5-formylthiophene-2-formonitrile plays an important role in many fields such as medicine, materials, agriculture, and other fields, promoting technological progress and innovation in various fields.

5-Formalylthiophene-2-formonitrile is one of the organic compounds. Its physical properties are unique and of great value for investigation.
Looking at its appearance, it is often in a solid state, which is its intuitive physical characterization. As for the color, or white to light yellow powder, the color is light and delicate.
When it comes to the melting point, it is about a specific temperature range. This value is of great significance for the identification and purification of the compound. Determination of its melting point is a key step in confirming the purity and characteristics of the substance.
Solubility is also an important physical property. In common organic solvents, such as dichloromethane and chloroform, 5-formylthiophene-2-formonitrile exhibits a certain solubility. This property enables it to be adapted to the corresponding solvent during the operation of organic synthesis to meet the conditions of various reactions.
In addition, the density of the compound also has its specific value. Although this value may not be often mentioned in general experimental operations, its importance is self-evident in the fields of accurate stoichiometry and material balance.
Furthermore, 5-formylthiophene-2-formonitrile exhibits unique spectral characteristics at specific wavelengths, such as infrared spectroscopy, nuclear magnetic resonance spectroscopy, etc., which are powerful means for identifying the structure and purity of the compound, and are also an important part of its physical property system. These physical properties are interrelated to build a unique physical property map of 5-formylthiophene-2-formonitrile, which is an indispensable element in the research and application field of organic chemistry.

5-formylthiophene-2-formonitrile, the price of this product in the market is difficult to hide. The price of the cover often varies for a variety of reasons.
First, it is related to the difficulty of preparation. If the preparation method is cumbersome, requires many delicate steps, and the raw materials are rare and difficult to find, or the reaction conditions are harsh, and the requirements for appliances and techniques are quite high, the price will be high. On the contrary, if the preparation process is relatively easy, the raw materials are widely distributed and easy to obtain, and the price may be slightly cheaper.
Second, it depends on the state of market supply and demand. If there is a surge in demand for 5-formylthiophene-2-formonitrile in the market, and there are few suppliers, the price will soar when the supply is in short supply. If there is little demand and the supply is full, the price will also decline.
Third, the scale of production also has an impact. When large-scale production is carried out, the unit cost may be reduced due to economies of scale, and the selling price will also decrease. However, small-scale output, the cost is difficult to reduce, and the price may be high.
Fourth, the geographical difference cannot be ignored. Different places have different prices due to differences in taxes, logistics costs, and human resources. In a prosperous city, if the cost is high, the price may be high; in a remote place, if the cost is low, the price may be slightly inferior.
Looking at the theory of "Tiangong Kaiwu", the price of everything depends on various things. Such as copper for casting money, its price varies due to the abundance of ore sources and the difficulty of mining and smelting; the silk of silk weaving also varies due to the harvest of sericulture and the simplicity of weaving. The price of 5-formylthiophene-2-formonitrile is just like the things in the book. It is difficult to determine an exact value due to the preparation, supply and demand, scale, and region.