5-Formyl-3-Thiophene Carboxylic Acid Methylester

Methyl 5-formyl-3-thiophenecarboxylate is an organic compound. It has a wide range of uses and is of great significance in the field of organic synthesis.
First, it is often used in drug synthesis. When building many drug molecules, methyl 5-formyl-3-thiophenecarboxylate can act as a key intermediate. Because of its specific chemical structure and active group, it can be cleverly combined with other compounds through a series of chemical reactions to construct complex drug molecules with specific pharmacological activities.
Second, it is also useful in the field of materials science. For example, in the preparation of some functional materials, specific functional groups can be introduced with the help of their structural characteristics, endowing the material with unique optical, electrical and other properties, providing the possibility for the research and development of new materials.
Furthermore, it also plays an important role in the synthesis of fine chemical products. When synthesizing fine chemicals such as special fragrances and dyes, it is used as an important starting material or intermediate to participate in the reaction, help obtain the target product, and improve the quality and performance of fine chemical products.
Therefore, 5-formyl-3-thiophenecarboxylate methyl ester, with its unique structure, is an important basic substance in many fields such as drugs, materials, and fine chemicals, and is of great significance to promote the development of various fields.

Methyl 5-formyl-3-thiophene carboxylate is also an organic compound. Its physical properties are of great value for investigation.
Looking at its properties, it is either a solid or a viscous liquid under normal conditions, which varies depending on the temperature and pressure of the environment.
When it comes to melting point, the melting point of this substance is specific. At a specific temperature, the solid phase will gradually melt into the liquid phase. Determination of melting point is crucial to identify its purity and characteristics. The melting point of pure 5-formyl-3-thiophene carboxylate is relatively stable. If it contains impurities, the melting point may be deviated.
In terms of boiling point, when the temperature rises to a certain value, the compound will change from the liquid phase to the gas phase, that is, reach the boiling point. The boiling point is determined by factors such as intermolecular forces. In its molecular structure, thiophene ring, formyl group and carboxylic acid methyl ester group interact, which affects the intermolecular attractive force, which in turn affects the boiling point.
Solubility is also a key property. The substance has good solubility in organic solvents, such as common ethanol, ethyl ether, dichloromethane, etc. Because its molecular structure has certain hydrophobicity, its solubility in water is poor. This solubility property is widely used in the separation and purification steps of organic synthesis.
Density is also one of its physical properties. Its density may be different from that of water, and it can be used in some separation operations due to the difference in density.
In addition, the compound may have a certain odor, but the description of the specific odor needs to be sensed by smelling, and when smelling, it should be operated according to the norms to beware of poisoning.
In summary, the physical properties of methyl 5-formyl-3-thiophene carboxylate are of great significance in the fields of organic synthesis, chemical analysis, etc. Researchers can carry out relevant experiments and applications based on this property.

The synthesis of methyl 5-formyl-3-thiophene carboxylic acid is an important topic in the field of organic synthesis. To obtain this compound, several paths can be followed.
First, starting from compounds containing thiophene structure, the formyl group can be introduced at a specific position of the thiophene ring first, and then the esterification reaction can be carried out to form methyl esters. For example, using 3-thiophene carboxylic acid as the starting material, suitable formylation reagents can be used, such as the combination of polyformaldehyde and zinc chloride, under specific conditions, the 5-position of the thiophene ring can be introduced into the formyl group to generate 5-formyl-3-thiophene carboxylic acid. This process requires careful control of reaction temperature, time and reagent dosage to prevent side reactions from occurring. Then, the obtained 5-formyl-3-thiophene carboxylic acid and methanol are esterified under acid catalysis. Commonly used acids such as concentrated sulfuric acid or p-toluenesulfonic acid can be heated and refluxed for a certain period of time to obtain 5-formyl-3-thiophene carboxylic acid methyl ester.
Second, the target molecule can also be constructed by multi-step reaction starting from thiophene derivatives containing appropriate substituents. For example, thiophene compounds with formyl and carboxyl methyl ester groups that can be converted are prepared first, and then converted in sequence. A specific substituent can be introduced into the thiophene ring through reactions such as nucleophilic substitution, and the substituent can be adjusted through oxidation, reduction and other steps to finally achieve the synthesis of methyl 5-formyl-3-thiophene carboxylate. Although this path has many steps, it can be flexibly adjusted according to raw materials and reaction conditions, and can better control the selectivity of each step of the reaction.
During the synthesis process, attention should be paid to the optimization of reaction conditions at each step, including temperature, solvent, catalyst and other factors, in order to improve the yield and purity of the reaction. At the same time, intermediates and products need to be accurately identified by means of analysis methods such as thin layer chromatography, nuclear magnetic resonance, and mass spectrometry to ensure the effectiveness and reliability of the synthesis path.

Methyl 5-formyl-3-thiophene carboxylate is also an organic compound. When storing it, be sure to pay attention to many matters.
The first to bear the brunt, the control of temperature is crucial. This compound should be stored in a cool place, away from high temperature. High temperature can easily cause changes in its chemical properties, or trigger reactions such as decomposition and polymerization, which can damage its quality. If the temperature is too high, it may cause its structure to be damaged and its efficacy to be impaired.
Second, the humidity should not be underestimated. It should be placed in a dry place, waterproof to vapor erosion. Moisture can easily cause the substance to be damp, or hydrolyzed, changing the chemical structure, causing its purity to decrease, which in turn affects subsequent use.
In addition, light should also be careful. It is advisable to hide in a dark place and avoid direct light. Light can promote photochemical reactions that change the properties of the substance, such as changes in color and decreases in activity.
Repeat, the storage place should be kept well ventilated. To prevent the accumulation of volatile gases and avoid potential dangers such as explosion and poisoning. If the gas accumulates, in case of open flame or static electricity, it may cause accidents.
Also, this compound may be toxic and corrosive to a certain extent. When storing, it must be isolated from other items, especially food, medicine, etc., to avoid cross-contamination and endanger life and health.
Storage containers should also be carefully selected. Containers with good corrosion resistance and sealing should be selected to ensure the purity of the substance, prevent it from reacting with the container, and prevent the risk of leakage. In this way, they can be properly stored to maintain their inherent properties and quality.

What you are inquiring about is the market price of methyl 5-formyl-3-thiophene carboxylate. However, this price is not static, and often varies depending on the supply and demand of the market, the quality of quality, the amount of production, and the flow of time.
In the past, if this compound was of high quality and purchased in large quantities in the chemical raw material market, the price per kilogram may be in the hundreds of yuan. If the purchase quantity is small, such as only a few grams or tens of grams, for laboratory use, the gram price may range from a few yuan to tens of yuan.
However, the market of chemical industry is changing rapidly. If the production of raw materials increases sharply in the near future, the supply exceeds the demand, and the price may drop; on the contrary, if the raw materials are scarce, the production is trapped, and there are many people in need, the price may rise. And in different places, due to the difference in logistics and taxes, the price also varies.
To know the exact price, you can go to the chemical raw material market mentioned in "Tiangong Kaiwu", or visit the merchants specializing in this compound, or consult the platform of chemical trading, to know the current exact market price.