5-Formyl-2-thiophenecarboxylic Acid

5-formyl-2-thiophenecarboxylic acid, which has a wide range of uses. In the field of medicine, it is often a key intermediate. In many drug synthesis pathways, it is used as a starting material and is converted into compounds with specific pharmacological activities through a series of chemical reactions. Taking some anticancer drug synthesis as an example, 5-formyl-2-thiophenecarboxylic acid is condensed with specific amine substances, and then reduced and cyclized to produce drug molecules that inhibit the growth of cancer cells.
In the field of materials science, it also plays an important role. It can be used to prepare functional polymer materials. By polymerizing with monomers containing specific functional groups, the resulting polymer materials have unique optoelectronic properties, which can be used in organic Light Emitting Diode (OLED), solar cells and other optoelectronic devices. For example, in OLED manufacturing, polymer materials containing 5-formyl-2-thiophenecarboxylic acid structure can improve the luminous efficiency and stability of the device.
In the field of organic synthetic chemistry, it is an important synthetic building block. Because there are two active functional groups of aldehyde group and carboxyl group in the molecule, it can participate in a variety of classical organic reactions, such as aldehyde group condensation reaction, carboxyl group can participate in esterification reaction, etc., to construct complex organic molecular structures, and help organic synthesis chemists explore the synthesis methods and routes of novel compounds.

5-formyl-2-thiophenecarboxylic acid, this is an organic compound. Its physical properties are particularly important and are related to many chemical and industrial applications.
Looking at its appearance, it is mostly solid at room temperature and pressure. As for the color, it often appears white to light yellow powder, which is convenient for the initial identification of the naked eye.
Its melting point is also one of the key physical properties. The melting point of 5-formyl-2-thiophenecarboxylic acid is within a specific range, and this value has a great impact on its phase transition, purification and crystallization process under specific conditions. Depending on the melting point, the purity of the compound can be judged. If the purity is high, the melting point usually approaches the theoretical value, and the melting range is narrow; if it contains impurities, the melting point decreases and the melting range becomes wider.
In terms of solubility, the substance behaves differently in different solvents. It has certain solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), but poor solubility in water. This difference in solubility is of great significance in the process of organic synthesis and separation. Chemists can use this property to select suitable solvents for reaction and product purification.
In addition, the density of 5-formyl-2-thiophenecarboxylic acid also has specific values. As a basic physical property of a substance, density is indispensable when it comes to solution preparation, material balance, and determining the distribution state of a substance in a specific system.
In summary, the physical properties of 5-formyl-2-thiophenecarboxylic acid, such as appearance, melting point, solubility, and density, play a crucial role in the field of organic chemistry, from basic research to actual production, providing key information and reference for relevant chemists.

5-Formalyl-2-thiophenecarboxylic acid, this is an organic compound. The stability of its chemical properties requires detailed investigation.
In its structure, there are both formyl groups (-CHO) and carboxyl groups (-COOH), and they are connected to thiophene rings. Formalyl groups have high reactivity and are easily oxidized. If they encounter strong oxidants, they can be oxidized to carboxyl groups, causing the molecule to become dicarboxylic acids. Under certain conditions, formyl groups can also participate in nucleophilic addition reactions, such as forming acetals with alcohols, which may affect their stability.
Carboxyl groups are acidic and can be partially ionized in aqueous solution to release hydrogen ions. In an alkaline environment, carboxyl groups can easily react with bases to form salts, and this process may change their chemical stability. At the same time, carboxyl groups can participate in esterification reactions and form esters with alcohols under the action of catalysts.
thiophene ring is a five-membered heterocyclic ring with certain aromaticity and is relatively stable. However, the substituents on the thiophene ring will affect the electron cloud distribution, which in turn affects the stability of the whole molecule. For example, the electron-absorbing effect of formyl group and carboxyl group may reduce the electron cloud density of the thiophene ring, and the activity may change in the electrophilic substitution reaction.
External factors also have a great impact on its stability. When the temperature rises, the vibration of various chemical bonds in the molecule intensifies, the reaction activity increases, and the stability decreases. Under light, some chemical bonds break or absorb photon energy, causing chemical reactions. In terms of humidity, if the environmental humidity is high, the compound or moisture absorption will affect its purity and stability.
In summary, the chemical properties of 5-formyl-2-thiophenecarboxylic acid are not stable. When storing and using, many factors should be paid attention to to to prevent chemical reactions from occurring to ensure its properties and purity.

The synthesis method of 5-formyl-2-thiophenecarboxylic acid has been known since ancient times. One method starts with thiophene, first brominates to obtain 2-bromothiophene, and then reacts with magnesium powder to prepare Grignard reagent. Then, reacts with carbon dioxide to obtain 2-thiophenecarboxylic acid. Afterwards, under suitable conditions, under specific oxidation means, such as mild oxidant treatment, 2-thiophenecarboxylic acid is oxidized to a formyl group at a specific position, and then 5-formyl-2-thiophenecarboxylic acid is obtained.
Another method uses 2-methylthiophene as the starting material. First, a suitable oxidant is used to selectively oxidize the methyl group to a carboxyl group in a suitable reaction environment to obtain 2-carboxyl-5-methylthiophene. Then, the methyl group is converted to formyl group by specific oxidation and substitution reactions, and the target product can also be obtained.
Another method uses ester compounds containing thiophene structures as raw materials. First, through hydrolysis, the ester group is converted into carboxyl group, and then through a series of oxidation and functional group conversion steps, the formyl group is introduced at a specific position in the thiophene ring to synthesize 5-formyl-2-thiophene carboxylic acid. All methods have their own advantages and disadvantages, and need to be selected according to actual needs, raw material availability and reaction conditions.

What you are asking about is the price range of 5-formyl-2-thiophenecarboxylic acid in the market. However, these prices often vary due to changes in time, place, quality, supply and demand, and it is difficult to determine the number.
In the past, if you wanted to know the price of something, you would rely on the talk of businesspeople and the visit of the market. In today's world, information is convenient, and you can use electronic devices to connect to the Internet. If you want to know the price of 5-formyl-2-thiophenecarboxylic acid, you can go to the website of chemical product trading, or consult the supplier of chemical materials.
Generally speaking, the price of chemical raw materials is affected by many factors. The cost of its production, such as the purchase of raw materials, the production process, and the amount of energy consumption, are all key. If raw materials are scarce, or the process is complicated, the cost will be high, and the price will also rise. And the trend of supply and demand, if there are many seekers and few suppliers, the price will tend to rise; on the contrary, if the supply exceeds the demand, the price may fall.
However, I have not personally involved in market surveys, so it is difficult to tell you the exact price range. You can follow the path I said and explore in detail to get the near-real price.