5 Chlorothiophene 2 Methanol
quinoline thiophene imidazole thiazole

5-Chlorothiophene-2-Methanol

Taiy Chemical

    Specifications

    HS Code

    875476

    Chemical Formula C5H5ClOS
    Molar Mass 148.61 g/mol
    Appearance Colorless to light yellow liquid
    Boiling Point Approximately 214 - 216 °C
    Solubility In Water Slightly soluble
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
    Flash Point Data varies, potentially around 90 °C
    Purity Typically available in high purity, e.g., 95%+ in commercial products
    Odor Characteristic sulfur - containing organic odor

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    General Information
    Where to Buy 5-Chlorothiophene-2-Methanol in China?
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    Frequently Asked Questions

    As a leading 5-Chlorothiophene-2-Methanol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 5-chlorothiophene-2-methanol?
    5-Bromouracil is a base analogue, which has a great impact on the transmission of genes and genetic information in organisms. Ethylamine also has important uses in many fields. The following is an ancient saying:
    5-bromouracil is a base analogue, which has a significant impact on the replication, transcription and transmission of genetic information in genes. This analogue can be incorporated into the synthesis process of DNA. Due to its structure being similar to normal bases, it can be paired with different bases during DNA replication, resulting in base mismatches. This mismatch may cause gene mutation, which alters the structure and function of the protein encoded by the gene, thereby affecting the traits and physiological functions of the organism. In molecular biology research, it is often used as a tool to explore the mechanism of gene mutation, helping researchers understand the process and impact of gene mutation.
    Ethylamine has a wide range of uses. In the chemical industry, it is often an important raw material for the synthesis of many organic compounds. For example, it can be used to prepare pesticides, enhance the insecticidal and bactericidal effects of pesticides, protect the growth of crops, and ensure the harvest of grain. In the pharmaceutical industry, ethylamine is also a key intermediate. In the synthesis path of many drugs, ethylamine participates in it, and the specific structure of the drug is constructed by chemical reaction to achieve the purpose of treating diseases. For example, the preparation of some drugs for the treatment of cardiovascular diseases and nervous system diseases requires the help of ethylamine. In addition, in the dye industry, ethylamine can be used to synthesize dyes with special structures, so that dyes have better dyeing properties and make fabrics more vivid and lasting. In the field of organic synthesis, with its active chemical properties, ethylamine can participate in a variety of reactions, providing the possibility for the synthesis of complex organic molecules and promoting the development of chemical, materials and other fields.
    What are the physical properties of 5-chlorothiophene-2-methanol?
    We have a good understanding of the chemical properties of 5-alkanes, and now we are exploring the physical properties of dimethyl ether. Dimethyl ether, a colorless gas at room temperature and pressure, has a slight aroma unique to ethers. Compared with other pungent or strong odors, this smell is milder and easy to accept by ordinary people.
    Its boiling point is about -24.9 ° C. This property allows it to quickly change from liquid to gaseous at slightly higher than normal temperatures, so it has unique advantages in some application scenarios that require rapid volatilization. The melting point is -141.5 ° C, indicating that it solidifies into a solid state at extremely low temperatures, showing good low temperature stability.
    Dimethyl ether has good miscibility with common organic solvents such as ethanol and acetone, and can be uniformly mixed with them to form a stable mixing system, which is of great significance in the preparation of solutions in chemical production. However, its solubility in water is relatively small, which is due to the large difference between the non-polar characteristics of its molecular structure and the polarity of water molecules, making it difficult for the two to fully interact.
    In terms of density, the density of dimethyl ether gas is slightly heavier than that of air, about 1.617kg/m ³ (air density is about 1.29kg/m ³), which means that in the absence of strong external interference, dimethyl ether gas will tend to accumulate at a lower position if it leaks. The density of liquid dimethyl ether is about 0.661 g/cm ³, which is lighter than the density of water at 1 g/cm ³. If the liquid of dimethyl ether comes into contact with water, it will float on the water surface.
    In addition, dimethyl ether also has a certain degree of volatility, which can quickly transform from liquid to gaseous and spread into the air, and its latent heat of evaporation is low, the gasification process is relatively easy to occur, and the heat absorbed is relatively small. These physical properties are interrelated and together determine the application mode and scope of dimethyl ether in industrial production, energy utilization and daily life related fields.
    What are the chemical properties of 5-chlorothiophene-2-methanol?
    Ethanethiol is a substance with special chemical properties. Its odor is extremely odorous, and even at very low concentrations, people can perceive it acutely. This property makes it used as a warning agent in odorless gases such as natural gas, so that when gas leaks, people can quickly detect it with its pungent smell and ensure safety.
    In terms of chemical activity, the sulfur-hydrogen bond (S-H) of ethanethiol is relatively fragile, easy to break, and then exhibits a certain acidity. Compared with alcohols, it is more acidic and can react with bases to form corresponding salts. For example, ethanethiol reacts with sodium hydroxide to form sodium ethanethiol and water.
    There are unshared electron pairs in the outer layer of the sulfur atom of ethanethiol, which makes it nucleophilic and can participate in many nucleophilic substitution reactions. For example, under appropriate conditions, ethanethiol can undergo nucleophilic substitution with halogenated hydrocarbons, and halogen atoms are replaced by ethanethiol groups to form new sulfur-containing organic compounds.
    In addition, ethanethiol also has unique performance in oxidation reactions. Under mild oxidation conditions, ethanethiol can be oxidized to disulfide. In more severe oxidation environments, it will be further oxidized to sulfonic acid.
    Furthermore, ethanethiol generates sulfur dioxide and other sulfur oxides when burned due to sulfur-containing elements, which makes it unique in combustion-related reactions and environmental impacts.
    It can be seen from the above that ethanethiol has chemical properties such as unique odor, acidity, nucleophilicity, and specific oxidation reactions due to its unique chemical structure, which make it have important uses and effects in many fields such as chemical industry and safety.
    What are the synthesis methods of 5-chlorothiophene-2-methanol?
    There are several common methods for the synthesis of 5-alkoxy-2-acetylfuran:
    One is to use furfural as the starting material. Furfural can be etherified first to introduce alkoxy groups. In this process, suitable alcohols can be selected to react with furfural under the catalysis of an acid or base to generate 5-alkoxy furfural. Then, 5-alkoxy furfural is acetylated and reacted with an acylating agent such as acetyl chloride or acetic anhydride under the action of a catalyst in a suitable solvent to obtain 5-alkoxy-2-acetylfuran. For example, furfural and ethanol are heated and refluxed under the catalysis of sulfuric acid to obtain 5-ethoxy furfural; then 5-ethoxy furfural and acetic anhydride are reacted in dichloromethane solvent with anhydrous aluminum trichloride as catalyst to obtain the target product.
    The second is a method of direct substitution reaction with furan derivatives. If a suitable furan derivative is selected, and its specific position already has a reactive active group, an alkoxy group and an acetyl group can be directly introduced through a nucleophilic substitution reaction. For example, some furan derivatives have a halogen atom at the 5th position, which can react with sodium alcohol to undergo nucleophilic substitution and introduce an alkoxy group; after that, the acetylation step is followed to achieve the synthesis of 5-alkoxy-2-acetylfuran. This method requires precise design of the structure of the starting furan derivative, and requires high control of the reaction conditions to ensure the selectivity of the substitution position.
    The third is the reaction involving organometallic reagents. A suitable organometallic reagent, such as Grignard reagent or lithium reagent, can first react with the furan derivative to form an active intermediate. This intermediate is then reacted with the corresponding halogenated alkyl or acylating reagent to achieve the introduction of alkoxy and acetyl groups. For example, furan is first reacted with n-butyl lithium to form a lithium furan intermediate, then reacted with halogenated alkanes to introduce alkoxy groups, and finally reacted with acetylating reagents to obtain 5-alkoxy-2-acetylfuran. This approach relies on the activity and selectivity of organometallic reagents, and the reaction conditions are relatively severe, requiring operation in an anhydrous and anaerobic environment.
    What are the precautions for storing and transporting 5-chlorothiophene-2-methanol?
    Those who are poisoned by mercury must pay more attention to the business of storage and transportation.
    Mercury is strong and poisonous. When hiding it, it must be contained in a secret container, and it should not be released outside. Choose a place to store, it should be cool and dry, away from direct sunlight and hot topics. Cover mercury is easy to dissolve gas when heated, and it is scattered in the room. If people absorb it, it will harm their bodies. The container should also be sturdy to prevent it from being damaged and causing mercury to overflow. Every inspector, if there is a leak, it should be disposed of quickly, and it should not be delayed.
    As for those who transport mercury, there are also all kinds of caution. The transport device should be specially made to fix mercury and prevent it from overflowing. During transportation, an enclosure must be added to absorb shocks and prevent collisions, so as to prevent the mercury from breaking out due to the bumps in the road. Escorts must be aware of the hazards of mercury and emergency measures. If mercury leaks on the way, don't be alarmed, but quickly cover it with sulfur. Because mercury and sulfur are easy to combine, non-toxic mercury sulfide can be dissolved. At the same time, evacuate everyone to avoid its poisonous gas.
    Mercury is a poison, and its storage and transportation are related to everyone's safety. Everything must be detailed and thorough, and there must be no negligence in the slightest. If you are not careful, the mercury poison will be scattered, endangering life, and harming the environment. It is too late to regret. Therefore, those who hide and transport mercury must be in awe, abide by its regulations, and abide by its laws, so that they can be safe.