5-Chloro-4-Methoxythiophene-3-Carboxylic acid

5-Chloro-4-methoxythiophene-3-carboxylic acid, a crucial compound in organic synthesis, has a wide range of uses.
In the field of medicinal chemistry, it can be used as a key intermediate to create drug molecules with specific biological activities. For example, some studies aim to synthesize new drugs targeting specific disease targets by modifying and modifying its structure. Due to its unique chemical structure, it can interact with specific receptors or enzymes in organisms, thus demonstrating potential therapeutic effects.
In the field of materials science, this compound also has important applications. With its special electronic properties and structure, it may be applied to the preparation of organic optoelectronic materials. After appropriate chemical conversion and polymerization reactions, polymer materials with specific photoelectric properties can be synthesized, such as for use in organic Light Emitting Diodes (OLEDs), solar cells and other devices, contributing to the improvement of the performance of these devices.
Furthermore, in the field of fine chemistry, 5-chloro-4-methoxythiophene-3-carboxylic acid can be used to prepare high-end fine chemicals. It can be used as a starting material, and through a series of chemical reactions, a variety of compounds with special functions can be derived, which can be used in fragrances, dyes and other industries to endow products in these industries with unique properties and quality. In summary, 5-chloro-4-methoxythiophene-3-carboxylic acid, with its unique structure and properties, plays an indispensable role in many fields such as medicine, materials, fine chemicals, etc. It has extremely broad application prospects and important research value.

There are various ways to synthesize 5-chloro-4-methoxythiophene-3-carboxylic acid. Although this specific compound was not mentioned in the previous "Tiangong Kaiwu", the method of the creation described in the previous "Tiangong Kaiwu" may have something to learn from the principle of synthesis today.
First, it can be started from the corresponding thiophene derivative. Using thiophene containing suitable substituents as raw materials, chlorine atoms can be introduced at specific positions first. By means of halogenation reaction, such as chlorine gas or chlorination reagents, under suitable reaction conditions, such as specific temperatures and catalysts, chlorine atoms can precisely replace hydrogen atoms at the target position. This step requires attention to the selectivity of the reaction to achieve the expected substitution check point.
After that, the methoxy group is introduced. It is often reacted with chlorinated thiophene derivatives with sodium alcohol or other alkoxylating agents. This reaction needs to be carried out in a suitable solvent system, and the temperature and reaction time need to be precisely controlled in order to successfully connect the methoxy group to the predetermined position.
As for the introduction of carboxyl groups, various strategies can be used. Common ones, such as halogenated alkyl nitriles, are first connected to thiophene derivatives, and then hydrolyzed to convert the nitrile group into a carboxyl group. In the hydrolysis step, suitable acid and base conditions need to be selected to ensure the smooth generation of carboxyl groups without affecting other introduced substituents.
Or you can start from active thiophene derivatives, borrow nucleophilic substitution, oxidation and other series of reactions to gradually construct the structure of the target molecule, and finally obtain 5-chloro-4-methoxythiophene-3-carboxylic acid. The whole process of synthesis requires careful consideration of the conditions of each step of the reaction and the selection of reagents, in order to obtain high yield and high purity products.

5-Chloro-4-methoxythiophene-3-carboxylic acid is one of the organic compounds. It has unique physical properties and is worth exploring.
When it comes to appearance, this compound is often in the form of white to off-white solid powder. This shape is easy to observe and operate. In many experiments and industrial processes, this appearance characteristic is conducive to preliminary identification and treatment.
Its melting point is also one of the important physical properties. However, the exact melting point varies slightly due to factors such as purity, and is roughly in a specific temperature range. The determination of the melting point can provide a key reference for the determination of the purity of the compound and subsequent applications. Knowing the melting point can help the experimenter control the reaction temperature and ensure that the reaction proceeds as expected.
In terms of solubility, 5-chloro-4-methoxythiophene-3-carboxylic acid exhibits different behaviors in organic solvents. Common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF) have a certain solubility. This property makes it possible to select a suitable solvent to promote the reaction in organic synthesis according to the needs of the reaction. In water, its solubility is relatively low, which limits its application in aqueous systems, but provides ideas for its separation and purification.
In addition, the stability of the compound is also a physical property consideration. Under normal temperature and pressure, if properly stored, it can maintain a relatively stable state. However, under extreme conditions such as high temperature, strong acid, and strong base, its structure may change, which affects its performance and application.
The physical properties of 5-chloro-4-methoxythiophene-3-carboxylic acid are of great significance in the fields of organic synthesis and drug development. Experimenters can rationally design the reaction route and optimize the experimental conditions according to its appearance, melting point, solubility and stability, and optimize the experimental conditions to achieve efficient utilization and transformation of the compound.

What you are asking about is the price range of 5-chloro-4-methoxythiophene-3-carboxylic acid in the market. However, "Tiangong Kaiwu" is an ancient book describing ancient agricultural and handicraft production techniques, and does not involve the price of this material.
Although there is no evidence of "Tiangong Kaiwu", the price of such chemicals often varies due to multiple reasons. Its purity is a major factor, and the price of high purity is high. If the purity reaches 99% or more, the price is several times higher than that of 95% purity.
Furthermore, market supply and demand also have an impact. If there are many people who want it, and the supply is small, the price will rise; on the contrary, if the supply exceeds the demand, the price may drop.
In addition, the difficulty of preparation is also related to the price. If the synthesis requires complicated steps, rare raw materials or special conditions, the price will be high.
Generally speaking, in the chemical raw material market, such compounds are packaged in small packages (such as 100 grams). If the purity is average, the price may be in the hundreds of yuan; if the purity is high and the quantity is large (kilogram level), it may range from one kilogram or several thousand yuan. However, this is only an approximate number, and the actual price shall be subject to the current market conditions.

5-Chloro-4-methoxythiophene-3-carboxylic acid, this is a chemical substance. Its storage conditions are very critical, related to the stability and quality of the substance.
According to the concept of "Tiangong Kaiwu", it is necessary to check the nature of the treasure. This acid has specific chemical properties. When storing, the temperature and humidity of the environment should be the first priority. It should be placed in a cool place away from direct sunlight. Due to light and high temperature or chemical reactions caused by it, its purity and structure will be damaged. The temperature should be controlled at a slightly lower temperature, about 15 to 25 degrees Celsius. If the temperature is too high, it may cause decomposition or deterioration.
The humidity should also not be underestimated. It should be stored in a dry place to avoid humid environments. Due to reactions such as moisture or hydrolysis, the molecular structure will be damaged. The humidity should be kept at a relatively low level, such as 40% to 60%.
In addition, the choice of storage container is also important. Corrosion-resistant containers, such as glass or specific plastic materials, should be used. Due to their stable chemical properties, they are not easy to react with the acid and can protect the substance from pollution and quality change.
Storage should also be kept away from fire sources, oxidants, etc., to prevent fire and violent chemical reactions. And it needs to be properly marked for access and management, and follow strict storage specifications to ensure the quality and stability of 5-chloro-4-methoxythiophene-3-carboxylic acid for subsequent applications.