5-Chloro-3-Methylbenzothiophene

5-Chloro-3-methylbenzothiophene is an organic compound with unique chemical properties. In its structure, the benzene ring is fused with the thiophene ring, and the chlorine atom and the methyl group are respectively connected to specific positions.
First of all, its physical properties are mostly solid at room temperature and pressure, due to strong intermolecular forces. Melting point and boiling point are affected by molecular structure and relative molecular weight. Its solid-state morphological stability is due to the close arrangement and interaction of molecules.
Chemical properties, the structure of benzothiophene gives it aromaticity, which makes the molecule relatively stable, but many typical reactions of aromatic compounds can also occur.
Electrophilic substitution reactions are an important class. The electron cloud density distribution of the benzene ring and the thiophene ring is uneven, resulting in different reactivity at different positions. The electron cloud density of the α position of the thiophene ring is high, and electrophilic substitution is easy to occur here. Taking the halogenation reaction as an example, under appropriate conditions, chlorine atoms can replace hydrogen atoms at the α position of the thiophene ring to form polyhalogenated products.
In addition, methyl has a push electron effect, which can affect the electron cloud density distribution of the benzene ring, making the electron cloud density of the adjacent and para-position relatively increase, which is conducive to the attack of electrophilic reagents. For example, under specific conditions, the electrophilic substitution reactions such as nitrification and sulfonation can occur in the o-and para-position of methyl.
5-chloro-3-methylbenzothi In the presence of suitable nucleophiles, chlorine atoms can be replaced to form new carbon-heteroatomic bonds, and a variety of compounds can be derived.
Due to the sulfur-containing atoms, 5-chloro-3-methylbenzothiophene can also participate in some sulfur-related reactions. For example, under specific oxidation conditions, sulfur atoms can be oxidized to form sulfoxides or sulfone compounds, thereby changing molecular polarity and reactivity.
In conclusion, 5-chloro-3-methylbenzothiophene has a unique structure and is of great value in the field of organic synthesis. Its diverse chemical properties provide rich possibilities for the synthesis of complex organic molecules.

5-Chloro-3-methylbenzothiophene is one of the organic compounds. Its physical properties are unique and diverse.
When it comes to properties, under room temperature, 5-chloro-3-methylbenzothiophene is mostly in a solid state, which is relatively stable and easy to store and transport. Looking at its appearance, it is usually a white or off-white crystalline powder with pure color, regular crystal structure, and fine and uniform texture.
Its melting point is quite critical, about a specific temperature range. This melting point determines the temperature node at which the solid state is converted into a liquid state when heated. It is of great significance for temperature control in many chemical operations, such as purification and synthesis. If the temperature is not properly controlled, or the state of the substance is changed, it will affect the reaction process and product purity.
The solubility of 5-chloro-3-methylbenzothiophene cannot be ignored. In organic solvents, such as common ethanol, ether, dichloromethane, etc., it exhibits a certain solubility. This property provides a good reaction environment in organic synthesis reactions, which can promote the full mixing of the reactants and accelerate the reaction. However, in water, its solubility is very small, which is due to the predominance of hydrophobic groups in its molecular structure, which makes it difficult for water molecules to interact with it.
Its density has a clear value under specific conditions, and this value is related to the distribution and behavior of substances in different media. Density can help researchers understand its positional relationship in solution or mixture, and has guiding value for separation, extraction and other operations.
In addition, the stability of 5-chloro-3-methylbenzothiophene is also an important physical property. Under conventional environmental conditions, its chemical structure is relatively stable and it is not easy to spontaneously undergo chemical reactions. However, under specific conditions, such as high temperature, light, strong acid and alkali, the stability may be damaged, causing molecular structure changes and resulting in property changes.
In summary, the physical properties of 5-chloro-3-methylbenzothiophene, such as its properties, melting point, solubility, density, and stability, have a profound impact on its application and research in the field of chemistry. Researchers need to be familiar with these properties in order to effectively use this compound in various work.

5-Chloro-3-methylbenzothiophene, an organic compound, is widely used in chemical and scientific research fields.
First, it plays a key role in drug synthesis. Because of its special chemical structure, it can introduce unique properties to drug molecules. It can be used as a key intermediate to participate in the construction of drug skeletons with specific biological activities. For example, when developing some anti-tumor drugs, by ingeniously modifying the structure of 5-chloro-3-methylbenzothiophene, the targeting and inhibitory effect of the drug on tumor cells can be optimized, and the drug can act more accurately on diseased cells while reducing damage to normal cells.
Second, in the field of materials science, it also has outstanding performance. It can be used as an important raw material for the preparation of high-performance organic optoelectronic materials. Due to its structure endowing the material with unique optoelectronic properties, integrating it into the organic Light Emitting Diode (OLED) material system can improve the luminous efficiency and stability of the device, make the display screen more colorful and have a longer service life; it can be used in the research and development of solar cell materials, or it can enhance the material's ability to absorb light and charge transport, and improve the photoelectric conversion efficiency of the battery.
Third, in the synthesis of pesticides, 5-chloro-3-methylbenzothiophene can be derived from compounds with high insecticidal and bactericidal activities. After rational structural modification, the pesticide can effectively resist a variety of crop diseases and pests, ensure the healthy growth of crops, improve crop yield and quality, and have a relatively small impact on the environment, which meets the needs of green agriculture development.
Fourth, it is a commonly used chemical reagent in scientific research and exploration. Chemists expand the methodology of organic synthesis by studying its reaction characteristics and transformation laws. Through different reaction conditions and reagent combinations, it realizes its diversified functional grouping, providing new ideas and methods for the synthesis of complex and novel organic compounds, and promoting the continuous development of organic chemistry.

The synthesis of 5-chloro-3-methylbenzothiophene is an important topic in the field of organic synthesis. Its synthesis path is diverse, and it is often obtained from specific starting materials through several steps.
Common starting materials, such as sulfur-containing compounds and halogenated aromatics, etc. Nucleophilic substitution can be used to combine sulfur-containing reagents with halogenated aromatics to form the basic skeleton of benzothiophene. For example, 2-chloro-5-methylthiophenol is reacted with a suitable halogenated hydrocarbon under alkaline conditions. The basic reagent can be potassium carbonate, etc., in a suitable solvent such as N, N-dimethylformamide (DMF), heated and stirred to promote nucleophilic substitution to form a preliminary product.
After that, the product needs to be halogenated to introduce chlorine atoms. A suitable halogenating reagent, such as N-chlorosuccinimide (NCS), can be selected to react in an inert solvent such as dichloromethane under the action of light or initiator to achieve the introduction of 5-position chlorine atoms, thereby obtaining 5-chloro-3-methylbenzothiophene.
Or from another idea, take the parent benzothiophene as the starting material, first methylate it, select suitable methylating reagents, such as iodomethane and base, and introduce methyl at a specific position of benzothiophene under appropriate reaction conditions. Subsequently, a halogenation reaction is carried out, and chlorine atoms are introduced according to the above halogenation method, which can also achieve the synthesis of the target product. < Br >
During the synthesis process, it is necessary to precisely control the reaction conditions, such as temperature, reaction time, reagent dosage, etc., which have a significant impact on the reaction yield and selectivity. After the reaction, it needs to go through separation and purification steps, commonly used column chromatography, recrystallization method, etc., to obtain high-purity 5-chloro-3-methylbenzothiophene.

I look at your question, it is about 5-chloro-3-methylbenzothiophene in the market price range. However, this substance was not mentioned in "Tiangong Kaiwu", and the scientific and technological level at that time did not yet have this fine chemical substance. Today, this chemical is more common in the field of modern chemical industry.
If you want to know its price range, it is difficult to generalize. Its price is affected by many factors, the first one being purity. High purity 5-chloro-3-methylbenzothiophene, due to the complicated refining process, has strict process requirements, and the price is not cheap; while those with slightly lower purity may be relatively affordable.
Furthermore, the market supply and demand situation is also the key. If there are many people who want it, but the output is limited, the so-called "rare things are expensive", and the price will rise; on the contrary, if the supply is abundant and the demand is not strong, the price may be lowered.
In addition, the different manufacturers also lead to different prices. Well-known large factories, due to brand reputation, quality control and other factors, their product pricing may be higher than that of ordinary manufacturers.
Overall, in the chemical raw material trading market, the price of 5-chloro-3-methylbenzothiophene per gram may range from tens to hundreds of yuan, but this is only a rough estimate. The actual price depends on the specific market conditions and product characteristics.