5-Chloro-2-thiophenesulfonyl chloride

5-Chloro-2-thiophenesulfonyl chloride is an important organic synthesis reagent. It has a wide range of main uses and is often a key intermediate in the synthesis of many drugs in the field of medicinal chemistry. Due to the unique chemical properties of thiophene ring and sulfonyl chloride group, it can combine various chemical reactions, such as nucleophilic substitution reaction, with different nucleophilic reagents to construct compounds with complex structures and specific biological activities. It plays a pivotal role in the creation of antibacterial, antiviral and antitumor drugs.
In the field of materials science, 5-chloro-2-thiophenesulfonyl chloride also has important applications. It can participate in the synthesis of polymers. By introducing thiophene structure, the polymer is endowed with special electrical and optical properties, such as the preparation of conductive polymers and photoelectric functional materials. Due to its high reactivity of sulfonyl chloride, it can effectively initiate polymerization reactions or chemically modify polymers to meet different material performance requirements.
Furthermore, in the field of pesticide chemistry, this compound can be used as a raw material for the synthesis of new pesticides. Through rational design of reactions, it can be converted into compounds with high insecticidal, bactericidal or herbicidal activities, providing strong protection for agricultural production. Its unique molecular structure helps to improve the selectivity and affinity of pesticides to specific targets and reduce the impact on the environment. In summary, 5-chloro-2-thiophenesulfonyl chloride has shown important application value in many fields such as medicine, materials, and pesticides due to its active chemical properties and unique structure, and has made significant contributions to the development of related fields.

5-Chloro-2-thiophenesulfonyl chloride is an organic compound with unique physical properties. Its appearance is often white to pale yellow crystalline powder, which is crucial in many chemical reactions and industrial applications.
The melting point is between 37 and 41 ° C. As an important physical property of substances, the melting point is indispensable for the identification and purification of this compound. In this temperature range, 5-chloro-2-thiophenesulfonyl chloride melts from solid to liquid state, and this phase change process is of great significance for its processing and use under specific temperature environments.
The boiling point is about 148-150 ° C/1.2 kPa. The boiling point characterizes the temperature conditions under which a substance changes from liquid to gaseous state, and this value reflects the volatility of the compound under a specific pressure. In related chemical operations, such as distillation separation, boiling point data plays a key role in controlling reaction conditions and ensuring product purity.
Solubility is also one of the important physical properties. 5-Chloro-2-thiophenesulfonyl chloride is soluble in some organic solvents, such as dichloromethane, chloroform, etc. This solubility facilitates its application in organic synthesis reactions, enabling it to fully contact and mix with other reactants, thereby promoting the smooth progress of the reaction.
In addition, 5-chloro-2-thiophenesulfonyl chloride has certain irritating properties. This property requires that during operation and use, appropriate protective measures must be taken, such as wearing protective gloves, goggles and working in a well-ventilated environment, to avoid harm to the human body. In conclusion, in-depth understanding of its physical properties is essential for the safe and efficient use of this compound.

The chemical synthesis of 5-chloro-2-thiophenesulfonyl chloride is an important research topic in the field of organic synthesis. The synthesis method can be started by thiophene.
First take thiophene, use appropriate chlorination reagents, such as chlorine gas or N-chlorosuccinimide, under suitable reaction conditions, such as in organic solvents, control temperature, light and other factors to chlorinate thiophene, and introduce chlorine atoms at the 5-position of the thiophene ring to obtain 5-chlorothiophene. Next, 5-chlorothiophene and a sulfonating agent, such as fuming sulfuric acid or chlorosulfonic acid, are carefully added dropwise under a specific reaction environment, such as at a low temperature, and then gradually heated to a suitable temperature to allow It undergoes a sulfonation reaction, introducing a sulfonic acid group at the 2-position of the thiophene ring to obtain 5-chloro-2-thiophenesulfonic acid.
Finally, 5-chloro-2-thiophene sulfonic acid is reacted with chlorinated reagents such as thionyl chloride or phosphorus pentachloride in an organic solvent under the condition of heating and reflux, and the sulfonic acid group is converted into a sulfonyl chloride group, then the target product 5-chloro-2-thiophene sulfonyl chloride is obtained.
Each step of the reaction requires precise control of the reaction conditions, including the ratio of reactants, reaction temperature, reaction time, etc., and each step requires separation and purification operations, such as extraction, distillation, recrystallization, etc., to ensure the smooth progress of the reaction and the purity of the product. In this way, high purity 5-chloro-2-thiophenesulfonyl chloride can be obtained.

5-Chloro-2-thiophenesulfonyl chloride is a chemical substance. During storage and transportation, many matters need to be paid attention to.
First words storage. This material is very active and should be stored in a cool, dry and well-ventilated place. Avoid hot topics and open flames to prevent accidents. The cover is easy to decompose due to heat, or it may cause danger. It needs to be stored in isolation from oxidizing agents, alkalis, etc. Due to its active chemical properties, contact with them may cause severe reactions. At the same time, the storage place should have corresponding leakage emergency treatment equipment and suitable containment materials, just in case.
Times and transportation. When transporting, it is necessary to ensure that the packaging is intact and the loading is safe. The transportation process needs to be protected from exposure to the sun, rain, and high temperature. The transportation vehicle should be equipped with the corresponding variety and quantity of fire-fighting equipment and leakage emergency treatment equipment. If a leak occurs during transportation, effective measures should be taken immediately. For example, quickly evacuate the personnel from the leaked contaminated area to a safe area, isolate them, and strictly restrict access. Emergency personnel need to wear self-contained positive pressure breathing apparatus and anti-acid and alkali work clothes. Do not let leaks come into contact with combustible substances. Small leaks can be mixed with sand, dry lime or soda ash, or washed with a large amount of water. After the washing water is diluted, it can be placed in the wastewater system. Large leaks need to be constructed or excavated for containment, and transferred to a tank car or a special collector for recycling or transportation to a waste treatment site for disposal.
In short, in the storage and transportation of 5-chloro-2-thiophenesulfonyl chloride, care must be taken and various safety guidelines must be strictly adhered to to to ensure the safety of personnel and the environment.

5-Chloro-2-thiophenesulfonyl chloride, the price of this product in the market is difficult to determine. The price often changes due to many reasons, such as the abundance of material sources, the difficulty of preparation, the amount of market demand, and the different seasons.
In the past, when materials were abundant, the preparation was slightly easier, and the market demand was normal, the price was relatively easy. If materials are scarce, the preparation process is suddenly increased and difficult, and the market demand is strong, the price will rise.
According to Guanfu's "Tiangong Kaiwu", the price of everything depends on the supply and demand and the difficulty of production. The same is true of 5-chloro-2-thiophenesulfonyl chloride. Based on common sense, its price may fluctuate between hundreds and thousands of yuan per kilogram. However, this is only a rough guess, not an exact number. To know the exact market situation, you must carefully observe the current market conditions, consult the merchants, brokers in the industry, or observe the platform of chemical product trading, in order to obtain its near-real price. In short, the market conditions are ever-changing, and the price is also impermanent, and the real-time situation must prevail.