5-Chloro-2-thiophenesulfonamide

5-Chloro-2-thiophene sulfonamide is one of the organic compounds. It has unique chemical properties. In this substance, the chlorine atom is connected to the thiophene ring and the sulfonamide group, and the structure is unique, resulting in its unique properties.
In terms of its physical properties, under normal circumstances, it may be a white to off-white solid powder with a certain melting point. Due to the arrangement and interaction of atoms in the molecule, the melting point value is specific, which is quite useful in identification and purification.
In terms of chemical properties, the sulfonamide group is weakly acidic and can react with bases to form corresponding salts. This reaction is used in organic synthesis or is a key step in the construction of new compounds. The activity of chlorine atoms is not low, and it can participate in nucleophilic substitution reactions. In case of nucleophilic reagents, chlorine atoms can be replaced to form derivatives with more complex structures. The reaction conditions may vary depending on the nucleophilic reagents used, and factors such as temperature and solvent can affect the reaction process and product yield. The
thiophene ring, as one of the parts of this compound, is aromatic and can participate in characteristic reactions of aromatics, such as electrophilic substitution reactions. Due to the characteristics of electron cloud distribution, the reaction check point is specific, and different functional groups can be introduced to expand the structural diversity of compounds, which is of great significance in the creation of new drugs, materials and other fields. 5-Chloro-2-thiophenesulfonamide is widely used in many fields such as organic synthesis and drug research and development due to its own chemical properties. It is an indispensable and important raw material in organic chemistry research and industrial production.

5-Chloro-2-thiophenesulfonamide is one of the organic compounds. It has a wide range of uses in the field of medicinal chemistry and is often a key intermediate for the creation of new drugs. With its unique chemical structure, it can participate in a variety of chemical reactions. After ingenious modification and transformation, compounds with specific biological activities can be obtained, or are antibacterial drugs that can inhibit the growth and reproduction of bacteria and protect the human body from diseases; or are drugs that regulate the physiological functions of the body and help the human body recover.
In materials science, it also has its uses. It can be treated by a specific process to introduce it into polymer materials to give the material different properties, such as enhancing the stability of the material and making it more durable in different environments; or improving the solubility of the material, broadening its application scope, and developing its effectiveness in coatings, adhesives and other fields.
Furthermore, in agricultural chemistry, it may become an important component in the development of new pesticides. After rational design and synthesis, pesticide products with high-efficiency insecticidal, bactericidal or herbicidal functions can be made to help agricultural production increase, protect crops from thriving, resist the invasion of pests and diseases, and ensure the stable development of agriculture. Overall, 5-chloro-2-thiophenesulfonamide has important uses in many fields such as medicine, materials, and agriculture due to its unique structure, and is an important chemical substance to promote the development of various fields.

The synthesis of 5-chloro-2-thiophenesulfonamide is an important research in the field of organic synthesis. Its synthesis path is diverse, and the following are common methods.
The starting material is often 2-thiophenesulfonyl chloride, which is easily obtained by the sulfonation reaction of thiophene. In an appropriate reaction vessel, 2-thiophenesulfonyl chloride is placed in a low temperature and alkaline environment. Usually, at a low temperature such as 0 ° C to 5 ° C, it is slowly added to the reaction system containing ammonia water. The amount of ammonia water needs to be precisely controlled, generally a slight excess is appropriate, in order to ensure that 2-thiophenesulfonyl chloride is fully reacted. In this process, 2-thiophenesulfonyl chloride undergoes nucleophilic substitution reaction with ammonia, and the chlorine atom is replaced by amino group to form 5-chloro-2-thiophenesulfonamide.
When reacting, pay attention to the pH value and temperature changes of the reaction system. The pH value should be maintained weakly basic. If the temperature is too high, side reactions may occur, such as the formation of polysubstituted products or the opening of thiophene rings. After the reaction is completed, the generated 5-chloro-2-thiophenesulfonamide solid can be separated from the reaction mixture by means of filtration. Subsequent recrystallization with appropriate solvents such as ethanol and water can improve the purity of the product.
In addition, 5-chloro-2-thiophene carboxylic acid is also used as the starting material. It is first converted into the corresponding acid chloride, and then reacted with ammonia to form an amide, and then the target product is obtained by sulfonation reaction 5-chloro-2-thiophene sulfonamide. Although this path is a little complicated, it can be flexibly selected according to the availability and cost of different starting materials.

5-Chloro-2-thiophenesulfonamide, an important organic compound in the field of fine chemicals, is often used as an intermediate in the synthesis of medicines and pesticides. As for its market price, it is difficult to generalize, because many factors will affect it.
First, the state of market supply and demand is the key. If the downstream industries such as pharmaceuticals and pesticides are booming, the demand for 5-chloro-2-thiophenesulfonamide will increase sharply, but the supply is limited, the price may rise. On the contrary, if the market demand is weak and the supply is excessive, the price may decline.
Second, the production cost also affects the price. The price of raw materials fluctuates, which has a great impact. If the price of raw materials for the production of 5-chloro-2-thiophenesulfonamide rises, the production cost rises, and the product price may also increase. In addition, the quality of the production process is related to the cost. Advanced and efficient processes may reduce costs and increase efficiency, while outdated processes may cause high costs and affect prices.
Third, production scale also plays a role. In large-scale production, enterprises may reduce the cost of unit products due to scale effects, and the price may be more competitive. For small-scale production enterprises, the cost may be relatively high, and the price will also be affected.
Fourth, the market competition situation cannot be ignored. There are many companies producing this product in the market, and the competition is fierce. In order to compete for share, companies may adopt strategies such as price reduction. If the market is close to monopoly, monopolies can set prices according to their own strategies.
As far as I know, the current market price of 5-chloro-2-thiophenesulfonamide fluctuates roughly between X million and Y million yuan per ton. However, this is only a rough range, and the actual price depends on factors such as specific purchase quantity, product purity, transaction time and location. To know the exact price, purchasers should discuss in detail with relevant manufacturers and distributors, and inquire from multiple parties to obtain the current market quotation.

5-Chloro-2-thiophenesulfonamide is a chemical substance. During storage and transportation, many matters need to be paid attention to.
When storing, the first choice of environment. When placed in a cool, dry and well-ventilated place. This may be susceptible to temperature, humidity and air due to its nature. If it is placed in a high temperature and humid place, it may cause chemical changes and damage its quality. For example, high temperature can promote its decomposition, and humid air or cause it to deliquescence are not conducive to its preservation.
Furthermore, keep away from fire and heat sources. This substance may be flammable to a certain extent or may react violently in contact with fire or heat, causing danger. In case of an open flame, it may cause combustion or even explosion, endangering the safety of the surroundings.
When storing, you should also pay attention to isolation from other substances. Do not mix with oxidants, acids, bases, etc. Because of its chemical properties, or chemically react with these substances. For example, when encountering a strong oxidant, or having an oxidation reaction, destroying its structure, and at the same time releasing a lot of energy, causing harm.
When transporting, the packaging must be solid and firm. Make sure that during transportation, the packaging is not damaged due to bumps and collisions, causing material leakage. Packaging materials should have good protective properties and can withstand a certain degree of external impact and environmental impact.
Transportation vehicles also need to be selected appropriately. Vehicles that have transported substances that have adverse effects on 5-chloro-2-thiophenesulfonamide should be avoided to prevent residual substances from reacting with them. And during transportation, the speed and route should be strictly controlled. Avoid passing through crowded areas and road sections near high temperatures and fire sources to prevent accidents. Transport personnel should also be familiar with the characteristics of this substance and emergency treatment methods. In case of emergencies, they can respond quickly and reduce hazards.