5-Chloro-2-thiophenecarboxylic acid hydrazide

5-Chloro-2-thiophene carboxylic acid hydrazide, this is an organic compound. It has many unique chemical properties.
From the structural point of view, the thiophene ring is its core, and the thiophene ring is aromatic and has good stability. The 5-position chlorine atom is connected to the 2-position formylhydrazide group, which gives the compound unique characteristics.
The chlorine atom has electron absorption, which affects the distribution of molecular electron clouds, causing the electron cloud density of the thiophene ring to decrease, making it more prone to electrophilic substitution. The reaction check point is also affected by the localization effect of chlorine atoms.
In the formylhydrazide group, the nitrogen atom contains a lone pair of electrons, which can be used as both a hydrogen bond donor and a hydrogen bond receptor, which makes the compound easy to interact with the check point molecules containing hydrogen bonds, or affect its physical properties, such as melting point, boiling point and solubility. And the formylhydrazide group has certain reactivity and can participate in many organic reactions, such as reacting with alaldehyde and ketone to form hydrazone compounds. This reaction is often used in organic synthesis to construct new carbon-nitrogen bonds and synthesize heterocyclic compounds.
In terms of solubility, the compound has a certain solubility in polar solvents such as ethanol and dimethyl sulfoxide due to its polar formyl group, but the existence of thiophene ring and chlorine atom limits its solubility in water, and the overall solubility is restricted by both molecular polarity and non-polar parts.
The unique chemical structure of 5-chloro-2-thiophene carboxylic acid hydrazide endows it with diverse chemical properties, which may have potential application value in organic synthesis, pharmaceutical chemistry and other fields.

5-Chloro-2-thiophenylhydrazide is an organic compound. It is commonly used in the field of medicinal chemistry and is often a key intermediate in the synthesis of many biologically active drugs. Due to its specific chemical structure, different functional groups can be connected through chemical reactions, and then new compounds with specific pharmacological effects can be created.
In the field of pesticide chemistry, it also has important uses. Or it can be used as a raw material for the synthesis of new pesticides. It can be designed and modified to give pesticides unique insecticidal, bactericidal or herbicidal properties, contributing to agricultural pest control.
Furthermore, in the field of materials science, it may be able to participate in the preparation of functional materials. By reacting or compounding with other substances, materials are endowed with special properties such as optics and electricity to meet the needs of special materials in different fields.
In addition, in organic synthesis research, 5-chloro-2-thiophenecarboxylic acid hydrazide is an important starting material. Chemists can carry out various organic reaction studies according to their structural characteristics, explore new synthesis methods and paths, expand the boundaries of organic synthesis chemistry, and lay the foundation for the synthesis of more complex and special functional organic compounds.

The synthesis of 5-chloro-2-thiophenecarboxylic acid hydrazide is an important matter in chemical synthesis. The first method can be started from 5-chloro-2-thiophenecarboxylic acid. First, 5-chloro-2-thiophenecarboxylic acid is co-heated with thionyl chloride. The combination of the two phases, thionyl chloride has strong chlorination, and can convert the carboxyl group into an acid chloride to obtain 5-chloro-2-thiophenecarboxylic chloride. After the reaction, in addition to the excess thionyl chloride, it can be distilled by distillation. Because of its low boiling point, it is easy to separate from the product.
Next, 5-chloro-2-thiophenoformyl chloride is reacted with hydrazine hydrate in a suitable solvent, such as ethanol. The amino group of hydrazine hydrate is nucleophilic, and it can attack the carbonyl carbon of the acid chloride. The chlorine leaves, and then forms 5-chloro-2-thiophenoformic acid hydrazine. During the reaction, the temperature needs to be controlled, because the hydrazine hydrate is active, the temperature is too high, or side reactions occur. Usually, an ice bath or low temperature heating is used to maintain a moderate temperature, and stirring is required to make the reactants fully contact and promote the reaction to proceed quickly.
Another method can be started with ethyl 5-chloro-2-thiophenecarboxylate. 5-chloro-2-thiophenecarboxylic acid and ethanol are esterified under the catalysis of concentrated sulfuric acid to obtain ethyl 5-chloro-2-thiophenecarboxylate. Concentrated sulfuric acid can promote the right shift of equilibrium and increase the yield of ester. After the reaction, the product is purified by neutralization, separation, distillation, etc.
Then, 5-chloro-2-thiophenecarboxylate is reacted with hydrazine hydrate. This reaction is also carried out in a suitable solvent. The amino group of hydrazine hydrate attacks the carbonyl carbon of the ester group, and the ethoxy group leaves to form 5-chloro-2-thiophene carboxylic acid hydrazide. This process also requires attention to temperature and stirring to ensure a smooth reaction, and the final product needs to be further purified by recrystallization to obtain a pure 5-chloro-2-thiophene carboxylic acid hydrazide.

5-Chloro-2-thiophenylhydrazide, this is an organic compound. During storage and transportation, many matters need to be paid attention to.
Bear the brunt, the storage environment is crucial. Be sure to store in a cool, dry and well-ventilated place. Because the compound may be sensitive to humidity and temperature, high temperature, humid environment, or cause it to deteriorate. If the humidity is too high, it may cause moisture decomposition, changing its physical and chemical properties; if the temperature is too high, it may accelerate chemical reactions and reduce its purity and stability.
Furthermore, it should be stored separately from oxidizing substances, acidic substances and alkaline substances. The chemical structure of 5-chloro-2-thiophenylhydrazide makes it possible to react with the above substances. Oxidative substances or cause oxidation, acidic and alkaline substances or acid-base reactions with them will destroy their structure and affect quality.
When transporting, the packaging must be stable and tight. Use suitable packaging materials to prevent damage due to collision and vibration during transportation. If the packaging is damaged, the compound is exposed to the external environment, which may not only change its own properties, but also cause pollution to the transportation environment, and even endanger the safety of transporters.
In addition, the transportation process should avoid exposure to the sun and rain. Exposure to the sun will increase the temperature, and rain will introduce moisture, which is not conducive to its stability. The means of transport must also be kept clean, dry, and free of residues that may react with them. This will ensure that 5-chloro-2-thiophenylhydrazide maintains its inherent properties and qualities during storage and transportation.

5-Chloro-2-thiophenylhydrazide, the market price range varies due to many factors.
Looking at the theory of "Tiangong Kaiwu" in the past, the price of all things in the world varies, depending on the place of origin, supply and demand, and production methods. This 5-chloro-2-thiophenylhydrazide is no exception.
If it is near the place of origin, the raw materials are abundant and the production is convenient, and the price may be slightly lower. Because there is no long-distance transshipment fee, the material is safe to use and the cost will drop. However, if it is located in a remote location, the raw materials need to come from a long way, and the road loss and freight are superimposed, the price will rise.
The trend of supply and demand is also the main reason. If there are many people in the market, but the output is limited, such as pharmaceutical companies developing new drugs, the demand for them increases greatly, and the merchants will be reluctant to sell and raise the price. The higher price can reach hundreds of yuan per kilogram. On the contrary, if there is a surplus of output, there are few applicants, and the merchants sell or reduce the price to sell, or only a few tens of yuan per kilogram.
Furthermore, the quality of the production method is related to the cost. Sophisticated production method, high yield and few impurities, although the initial investment may be large, the cost is controllable in the long run, and the price may be moderate. The crude method, with low yield and many impurities, requires multiple purification, and the cost rises and the price is also high. Therefore, the market price range of 5-chloro-2-thiophenylhydrazide is roughly between tens of yuan and hundreds of yuan per kilogram.