5-Chloro-2-thiophenecarboxaldehyde

5-Chloro-2-thiophenylformaldehyde is a kind of organic compound. Its properties are light yellow to yellow liquid, stable at room temperature and pressure.
This compound has specific physical properties. Its boiling point is about 116-118 ° C. At this temperature, the substance converts from liquid to gaseous. The relative density is about 1.359, which characterizes its relative relationship with water density. The refractive index is about 1.588-1.592, which is related to the degree of refraction of light when passing through the substance.
The chemical properties of 5-chloro-2-thiophenylformaldehyde are also critical. The aldehyde group (-CHO) is an important functional group, which endows the compound with many typical chemical activities. The aldehyde group is prone to oxidation and can be oxidized to a carboxyl group (-COOH). In case of strong oxidizing agent, it can be converted into 5-chloro-2-thiophenecarboxylic acid. At the same time, the aldehyde group can participate in the reduction reaction and can be reduced to an alcohol hydroxyl group (-CH ² OH) to obtain 5-chloro-2- (hydroxymethyl) thiophene.
In addition, the halogen atom (chlorine atom) of the compound also has chemical activity. Under appropriate reaction conditions, the chlorine atom can undergo a substitution reaction and be replaced by other atoms or groups. For example, when reacted with nucleophiles, chlorine atoms can be replaced by alkoxy groups, amino groups, etc., thereby deriving a series of different compounds and expanding their applications in the field of organic synthesis.
5-Chloro-2-thiophenaldehyde is widely used in the field of organic synthesis due to the above chemical properties, and can be used as a key intermediate for the preparation of a variety of organic compounds such as drugs, pesticides and functional materials.

The synthesis method of 5-chloro-2-thiophene formaldehyde has been known since ancient times. There are many methods, and each has its own advantages.
One of them can be obtained by oxidation of 5-chloro-2-thiophene methanol. Take an appropriate amount of 5-chloro-2-thiophene methanol, place it in a suitable reaction vessel, and add a specific oxidant, such as chromium trioxide-pyridine complex. Control the temperature within a certain range, or at room temperature, or heat it to a moderate temperature, such as 50-60 degrees Celsius. In the meantime, stir evenly to make the reaction fully proceed. After a certain period of time, after the reaction is completed, 5-chloro-2-thiophene formaldehyde can be obtained by separation and purification methods, such as extraction, distillation, recrystallization, etc.
Second, 5-chlorothiophene is used as the starting material. First, 5-chlorothiophene is acylated with the corresponding reagent. Choose a suitable acylation reagent, such as acetyl chloride, etc., and use anhydrous aluminum trichloride as a catalyst to react in an anhydrous environment. The reaction temperature also needs to be carefully adjusted, about 0-10 degrees Celsius is appropriate. After the reaction is completed, a series of separation and purification steps are followed to obtain pure 5-chloro-2-thiophenylformaldehyde.
Third, 2-methyl-5-chlorothiophene can be used. First, 2-methyl-5-chlorothiophene is oxidized to 5-chloro-2-thiophenylcarboxylic acid with a suitable oxidant. The oxidant in this process can be selected from potassium permanganate, etc. After that, 5-chloro-2-thiophenecarboxylic acid is converted into 5-chloro-2-thiophenylformaldehyde by specific reduction methods, such as using reducing agents such as lithium aluminum hydride, under strict conditions such as low temperature and no water. After the reaction is completed, suitable separation and purification methods are required to prepare products with higher purity.

5-Chloro-2-thiophenylformaldehyde has a wide range of uses. In the field of pharmaceutical synthesis, it is often a key intermediate. The unique chemical activity of the thiophene ring and the chlorine atom can be combined with other functional groups through various organic reactions to prepare a variety of compounds with specific pharmacological activities. For example, when developing new antibacterial drugs or drugs for the treatment of cardiovascular diseases, 5-chloro-2-thiophenylformaldehyde may be used as a starting material to construct the core structure of the drug through multi-step reactions, contributing to the cause of human health.
It is also useful in the field of materials science. Using it as a raw material, materials with special photoelectric properties can be prepared. Due to its structural characteristics, the prepared materials may exhibit excellent properties in the fields of organic Light Emitting Diodes (OLEDs) and solar cells. For example, in OLED materials, 5-chloro-2-thiophene formaldehyde-derived compounds may optimize luminous efficiency and stability and improve display effect.
In addition, in the fine chemical industry, 5-chloro-2-thiophene formaldehyde can be used to synthesize various fine chemicals. Such as special fragrances, dye intermediates, etc. In the synthesis of fragrances, the products it participates in the reaction may have a unique aroma, adding a unique flavor to the fragrance formula; in the synthesis of dye intermediates, it can endow dyes with better color, fastness and other properties to meet different industrial and life needs.

5-Chloro-2-thiophene formaldehyde, the price of this product in the market is difficult to determine. Its price often changes due to many reasons, and in today's world, the market is complicated, and it is difficult to have a definite number.
Looking at the past, the price of materials depends mostly on the wide and narrow source of production and the difficulty of production. If the source is abundant and the production is convenient, the price may be flat; if the source is rare and the production is complicated, the price will be expensive.
The preparation of 5-chloro-2-thiophene formaldehyde may require exquisite methods and rare materials, which can make its price fluctuate. And the change in supply and demand in the commercial market is also the main reason. If there are many people seeking, and there are few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, the price will fall.
Also, different places for inter-city transactions have different prices. In the city of Dabu, where merchants gather, the competition is quite fierce, and the price may be relatively easy; in remote places, the circulation of goods is inconvenient, and the price may increase.
Furthermore, the times change, and the price of materials also changes with the world conditions. The passage of time, or new laws are made, causing the price of its products to increase and fall; or when the weather is not smooth, the price of materials may rise. < Br >
In order to know the current market price of 5-chloro-2-thiophene formaldehyde, it is necessary to widely observe various cities and consult various merchants to obtain a closer figure, but it is only a temporary price, and it is difficult to maintain the same price for a long time.

5-Chloro-2-thiophene formaldehyde is one of the organic compounds. During storage and transportation, many matters need to be paid attention to.
First talk about storage. This substance should be placed in a cool and dry place, away from fire and heat sources. Because of its flammability, it is easy to cause fire if it is close to the fire. Also avoid mixing with oxidants, because the oxidant meets with 5-chloro-2-thiophene formaldehyde, or it may cause a violent chemical reaction, which may pose a safety risk. Storage should be well ventilated to prevent the accumulation of harmful gases. And should be sealed and stored, otherwise it is vulnerable to moisture, oxygen, etc. in the air, causing it to deteriorate.
As for transportation, it should not be neglected. It is necessary to ensure that the packaging is intact. If the packaging is damaged, the material leaks, or the environment is polluted, it will also endanger the safety of the transportation personnel. During transportation, the vehicle should run smoothly to avoid violent vibration and collision to avoid damage to the packaging. The interior of the transportation vehicle should also be clean and dry, and there should be no other chemical residues to prevent mutual reaction. At the same time, the transportation personnel need professional training, familiar with the characteristics of 5-chloro-2-thiophene formaldehyde and emergency treatment methods. Once a situation occurs, it can be properly disposed of in time to ensure the safety of transportation.