5 Bromothiophene 2 Carboxylate
quinoline thiophene imidazole thiazole

5-bromothiophene-2-carboxylate

Taiy Chemical

    Specifications

    HS Code

    430833

    Chemical Formula C5H3BrO2S
    Molecular Weight 209.04
    Appearance Solid (usually white to off - white)
    Odor May have a characteristic odor
    Solubility In Water Poorly soluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Melting Point Varies depending on purity, typically in a certain range
    Boiling Point Relatively high, specific value depends on conditions
    Density Specific density value based on experimental data
    Flash Point Determined by appropriate testing methods

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    General Information
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    Frequently Asked Questions

    As a leading 5-bromothiophene-2-carboxylate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the physical properties of 5-bromothiophene-2-carboxylate?
    5-Bromothiophene-2-carboxylic acid esters are a class of compounds in organic chemistry. Their physical properties are well-researched.
    When it comes to appearance, they are often in a solid state, but they may vary depending on the specific structure and surrounding environment. The color of this compound is mostly white to light yellow powder or crystal, and the texture is delicate. When viewed under light, it may show a little luster, like a fine treasure.
    Its melting point is quite critical. Different 5-bromothiophene-2-carboxylic acid esters have different melting points. Generally speaking, the melting point of such compounds is often within a certain range, or fluctuates due to differences in intermolecular forces and spatial structures. The characteristics of this melting point are an important basis for separation, purification and identification.
    Solubility is also a significant physical property. In organic solvents, such as common ethanol, acetone, dichloromethane, etc., 5-bromothiophene-2-carboxylate often exhibits good solubility and can be fused with it to form a uniform solution. However, in water, due to the hydrophobic properties of its molecular structure, the solubility is poor, only slightly soluble or even insoluble.
    Furthermore, its density is also one of the physical properties. Although the specific value varies depending on the precise structure of the compound, in general, its density may be similar to that of common organic compounds, slightly greater than that of water. The physical properties of 5-bromothiophene-2-carboxylic acid esters are of great significance in many fields such as organic synthesis and medicinal chemistry, laying the foundation for related research and application.
    What are the chemical properties of 5-bromothiophene-2-carboxylate?
    5-Bromothiophene-2-carboxylic acid esters are a class of organic compounds with unique chemical properties.
    Its chemical activity is considerable, which is due to the synergistic effect of bromine atoms with thiophene rings and carboxylic acid ester groups. Bromine atoms are electron-absorbing groups, which can reduce the electron cloud density of thiophene rings, making thiophene rings more susceptible to electrophilic substitution reactions. For example, when encountering electrophilic reagents such as halogenating agents and nitrifying agents, the reaction check points often focus on the relatively high electron cloud density of thiophene rings, and the localization effect of bromine atoms also affects the regioselectivity of the reaction, and most tend to introduce substituents at specific positions in thiophene rings.
    Carboxylic acid ester groups give the compound another reactivity. Under basic or acidic conditions, hydrolysis can occur. In an alkaline environment, the corresponding carboxylic salts and alcohols can be formed by hydrolysis. This hydrolysis process follows the nucleophilic substitution mechanism. Hydroxide ions attack carbonyl carbons nucleophilically, which in turn promotes ester bond fracture. Under acidic conditions, the hydrolysis reaction starts with protonation, which enhances the electrophilicity of carbonyl carbons, and can also achieve the purpose of hydrolysis to form carboxylic acids and alcohols.
    In addition, the conjugated system of thiophene ring in 5-bromothiophene-2-carboxylic acid ester endows it with certain electron transport properties, which shows potential application value in the field of organic semiconductor materials. The conjugated structure allows electrons to move relatively freely within the molecule, laying the foundation for the construction of materials with specific electrical properties.
    At the same time, the compound can also participate in various organic reactions such as esterification and amidation. By interacting with alcohols, amines and other reagents, it can achieve ingenious modification and derivatization of molecular structures, providing the possibility for the synthesis of organic compounds with more complex structures and more diverse functions. In short, 5-bromothiophene-2-carboxylate has rich chemical properties and application potential in many fields such as organic synthesis and materials science due to its unique structure.
    What are the common synthetic methods of 5-bromothiophene-2-carboxylate?
    The common synthesis methods of 5-bromothiophene-2-carboxylic acid esters are quite important topics in the field of organic synthesis. There are many synthesis paths, and the following are common ones.
    First, thiophene is used as the starting material. First, thiophene is brominated, and suitable brominating reagents such as liquid bromine and N-bromosuccinimide (NBS) can be selected. Under suitable reaction conditions, such as specific solvents, temperatures and catalysts, bromine atoms are selectively substituted for hydrogen atoms at the 5-position of thiophene to obtain 5-bromothiophene. Then, 5-bromothiophene is carboxylated. With the help of Grignard reagent method, 5-bromothiophene can be first made into Grignard reagent, then a carboxyl group can be introduced by reaction with carbon dioxide, and finally 5-bromothiophene-2-carboxylate can be formed by esterification reaction with the corresponding alcohol under acid catalysis or other suitable conditions.
    Second, thiophene derivatives containing suitable substituents can also be started. If the starting material already has some of the required substituents, the structure of the target molecule can be gradually constructed through a series of reactions such as nucleophilic substitution, oxidation, and esterification. For example, if the starting material has a suitable substituent group on the thiophene ring, and its position and reactivity are suitable, a bromine atom can be introduced through a nucleophilic substitution reaction, and then a carboxyl group and esterification can be constructed through subsequent reactions to obtain 5-bromothiophene-2-carboxylic acid ester.
    Third, the coupling reaction catalyzed by transition metals is also a commonly used method. Using bromine-containing thiophene derivatives and carboxyl groups or reagents that can be converted into carboxylic groups as raw materials, under the action of transition metal catalysts such as palladium catalysts, carbon-carbon bonds or carbon-heteroatom bonds are formed through coupling reactions, and then the target carboxylic acid ester structure is constructed. The reaction conditions must be strictly controlled during the reaction, including the amount of catalyst, the selection of ligands, the type and amount of bases, the reaction temperature and time, etc., to ensure the high efficiency and selectivity of the reaction.
    All these synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider the specific needs, raw material availability and feasibility of reaction conditions, and carefully select the appropriate synthesis path to achieve the efficient synthesis of 5-bromothiophene-2-carboxylate.
    5-bromothiophene-2-carboxylate in what areas?
    5-Bromothiophene-2-carboxylate is used in various fields. Looking at it in the field of medicine, this compound may be a key raw material for the creation of new drugs. With its unique chemical structure, it can be chemically modified to derive a variety of biologically active substances, which may show significant effects in the treatment of diseases, such as anti-tumor and anti-virus genera.
    As for the field of materials science, 5-bromothiophene-2-carboxylate also has great potential. It can be used to participate in specific reactions to prepare polymer materials with specific properties. These materials may have excellent electrical and optical properties, and can be used in electronic devices, optical devices, etc., such as for the manufacture of high-efficiency organic Light Emitting Diodes to improve their luminous efficiency and stability.
    In the field of organic synthesis, 5-bromothiophene-2-carboxylate is often used as an important intermediate. With its bromine atom and carboxyl group activity, other functional groups can be easily introduced to build complex organic molecular structures, laying the foundation for the synthesis of a wide variety of organic compounds, and promoting the development of organic synthesis chemistry.
    In the agricultural field, this compound can be reasonably converted to produce biologically active pesticides. It may play an efficient role in controlling specific pests and diseases, and be more environmentally friendly than traditional pesticides, reducing the negative impact on the ecological environment.
    In summary, 5-bromothiophene-2-carboxylate has considerable application value and development potential in many fields such as medicine, materials, organic synthesis and agriculture.
    What is the market price of 5-bromothiophene-2-carboxylate?
    5-Bromothiophene-2-carboxylate, the price of this product in the market is really difficult to determine. The change in its price is related to various factors and is complicated.
    The first to bear the brunt is the scale of production. If the workshop is widely set up, the equipment is well-equipped, the manpower is complete, and the output is abundant, the price may be more affordable. In the past, there were factories in a certain city, and the production of such products was good. At first, the quantity was small, and the price was very high. Later, it was expanded. The quantity increased and the price gradually fell. There were many buyers in the four directions.
    Furthermore, the price of raw materials is also the key. The manufacture of 5-bromothiophene-2-carboxylate requires specific raw materials. If the raw materials are rare, or the supply is difficult due to the weather and origin, the price will rise. In the past, it was heard that a disaster in the origin of a raw material caused a shortage of supply, and the prices of 5-bromothiophene-2-carboxylate produced by various factories skyrocketed.
    And the demand of the market affects its price. If various industries need it, such as medicine and chemical industry, it is widely used and urgent, and the price will tend to rise; on the contrary, if there is no big demand, the price will be difficult to revive. At a certain time, the medical industry was prosperous, and the demand for 5-bromothiophene-2-carboxylate increased greatly, and the price rose several times at a time.
    The difference in quality also involves the price. High purity, excellent quality, the price is higher than that of crude products. In the past, there were Jia people who sold refined 5-bromothiophene-2-carboxylate. Although the price is high, there are many buyers, all because of its good quality and beneficial to users.
    In summary, the market price of 5-bromothiophene-2-carboxylate often changes due to various factors such as production scale, raw material prices, market demand, and quality differences. To know the real-time price, when you carefully observe the market situation and consult the industry, you can get a more accurate number.