5-Bromothiophene-2-carboxilic acid

5-Bromothiophene-2-carboxylic acid, this is an organic compound. In terms of physical properties, it is mostly in a solid state at room temperature, and its color may be white to light yellow. Due to the inclusion of bromine atoms and carboxyl groups, its relative molecular weight increases, the intermolecular force is enhanced, and the melting point and boiling point may be higher. And carboxyl groups can cause molecules to have a certain polarity and have a certain solubility in water, and the solubility in organic solvents such as ethanol and ether may be better.
In terms of chemical properties, carboxyl groups are acidic and can neutralize with bases to form corresponding carboxylic salts and water. If reacted with sodium hydroxide, 5-bromothiophene-2-carboxylate and water are formed. At the same time, the carboxyl group can participate in the esterification reaction, react with alcohols under acid catalysis to form esters and water.
Bromine atoms on the thiophene ring can undergo nucleophilic substitution reaction. Due to its large electronegativity, the electron cloud density on the thiophene ring is reduced, and the electron cloud density of the ortho and para-site is relatively high. Nucleophiles are easy to attack the ortho and para-site, causing bromine atoms to be replaced. In addition, the thiophene ring is an aromatic heterocycle with certain aromaticity, which can undergo electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. However, the presence of bromine atoms and carboxyl groups will affect the reaction activity and regioselectivity. < Br >
It has a wide range of uses in the field of organic synthesis and can be used as a key intermediate for the synthesis of many organic compounds with biological activity or special functions.

5-Bromothiophene-2-carboxylic acid, this substance has a wide range of uses. In the field of pharmaceutical synthesis, its position is crucial. Because of the compounds containing thiophene structure, many have unique biological activities, 5-bromothiophene-2-carboxylic acid can be a key intermediate for the synthesis of a variety of specific drugs. For example, in the development of antibacterial and anti-inflammatory drugs, this is the starting material, and through a series of chemical reactions, a molecular structure with specific pharmacological activities can be constructed, which can further benefit patients.
In the field of materials science, it also has its uses. Due to the properties of bromine atoms and thiophene rings in its structure, it can participate in the preparation of organic materials with unique functions. When preparing organic optoelectronic materials, the introduction of this compound can optimize the electronic transport properties and optical properties of the materials, so that the prepared materials can play a good role in Light Emitting Diode, solar cells and other devices, and improve the performance and efficiency of the devices.
Furthermore, in the field of pesticide chemistry, 5-bromothiophene-2-carboxylic acid is also indispensable. On this basis, pesticides with high insecticidal and bactericidal properties can be synthesized. After rational molecular design and modification, the prepared pesticides can accurately act on specific targets of pests, achieve the purpose of efficient prevention and control, and have little impact on the environment, which is in line with the current concept of green environmental protection. Overall, 5-bromothiophene-2-carboxylic acid has important uses in many fields and has made significant contributions to the development of various industries.

The synthesis method of 5-bromothiophene-2-carboxylic acid is an important research in the field of organic synthesis. The following are common synthetic routes.
First, thiophene is used as the starting material. The thiophene is first brominated, and liquid bromine and a suitable catalyst, such as iron powder, can be selected. Under suitable temperature and reaction conditions, the bromine atom replaces the hydrogen atom at a specific position on the thiophene ring to generate 5-bromothiophene. Subsequently, by carboxylation reaction, such as the Grignard reagent method. 5-Bromothiophene is made into Grignard reagent, magnesium chips and anhydrous ether are used as the reaction system. After Grignard reagent is made, carbon dioxide gas is introduced, and then hydrolyzed to obtain 5-bromothiophene-2-carboxylic acid. This process requires attention to the precise control of reaction conditions, such as the maintenance of anhydrous and anaerobic environment, the regulation of temperature and reaction time. Due to the active nature of Grignard reagent, it is easy to have side reactions in contact with water and oxygen, which affects the yield and purity of the product.
Second, thiophene derivatives containing carboxyl groups can also be used as raw materials. If there are suitable thiophene-2-carboxylic acid derivatives, selective bromination can be used. A suitable brominating reagent, such as N-bromosuccinimide (NBS), is selected to realize the bromination of the 5-position thiophene ring under the action of light or initiator. This method needs to consider the influence of the substrate structure on the reaction selectivity, and also requires the reaction solvent, reaction temperature and other conditions. Suitable reaction conditions can improve the selectivity and yield of the target product.
Furthermore, the coupling reaction strategy catalyzed by transition metals can also be used. For example, the coupling of carbon-carbon bonds is achieved by using halogenated thiophene and carboxyl-containing nucleophiles under the action of transition metal catalysts such as palladium catalysts, and then 5-bromothiophene-2-carboxylic acid is synthesized. This kind of method requires the selection of suitable ligands to enhance the activity and selectivity of the catalyst, and the pH, temperature and other factors of the reaction system have a significant impact on the reaction process and product formation. The reaction conditions need to be carefully optimized in order to obtain a better synthesis effect.

I look at your question, but I am inquiring about the price range of 5-bromothiophene-2-carboxylic acid in the market. In the market of chemical materials, the price of this compound often varies due to quality, supply and demand, and purchase quantity.
In the past, if the purchase quantity is small, it only needs a little experimental investigation, etc., its price per gram may be in the tens of yuan. Because of its preparation or exquisite process, the raw materials also have specific requirements. If you buy it in small quantities, the unit price will be higher under the cost sharing.
If it is for industrial use, buy it in large quantities, such as kilograms. Due to economies of scale, the cost is slightly reduced, and the price per kilogram may be in the range of several thousand yuan. However, this is not a fixed number. If the raw materials are suddenly tight, or the cost increases or decreases due to the innovation of the preparation process, the price will also fluctuate.
And the quality also affects the price. High purity, less impurities, suitable for high-end scientific research, fine chemicals, and the price must be higher than ordinary purity. And different seasons, the market supply and demand situation is different, and the price also fluctuates. Therefore, to know the price, when consulting chemical raw material suppliers, get accurate prices with real-time information.

5-Bromothiophene-2-carboxylic acid is an organic compound, and its storage conditions are very critical. This compound should be stored in a cool, dry and well-ventilated place.
A cool environment can maintain the temperature at a low level, and it is generally recommended to store between 15 ° C and 25 ° C. Due to high temperature, the compound may undergo chemical reactions such as decomposition and deterioration, which will damage its chemical properties and purity. High temperature may cause chemical bonds within the molecule to break, causing structural changes, which in turn affect its performance in subsequent chemical synthesis or other applications.
Drying conditions are also indispensable. 5-Bromothiophene-2-carboxylic acid may have certain hygroscopicity. If the ambient humidity is high, it is easy to absorb water vapor in the air and make itself deliquescent. Deliquescence will not only change its physical form, from solid to liquid or semi-solid, but also may promote reactions such as hydrolysis, reducing its purity and quality. Therefore, the relative humidity of the storage place should be controlled at 40% to 60%. A dry environment can be maintained with the help of desiccants such as silica gel.
Good ventilation is also an important factor. Good ventilation can quickly disperse harmful gases that may be generated by the volatilization of the compound and avoid the accumulation of harmful gases. The gases evaporated by this compound may be harmful to the human body, and the accumulated gases may have safety hazards such as explosions under specific conditions.
Furthermore, 5-bromothiophene-2-carboxylic acid should be kept away from fire sources, heat sources and oxidants. It is flammable to a certain extent and is easy to burn in case of fire sources and heat sources, causing fire accidents. The oxidant can oxidize with the compound, causing it to deteriorate, so it needs to be separated from the oxidant during storage to ensure safety.
In terms of packaging, a well-sealed container, such as a glass bottle or a plastic bottle, should be selected, and the cap should be tightened to prevent air and water vapor from entering. The packaging material should not chemically react with the compound to maintain its stability and purity.