5-Bromo-thiophene-2-carboxylic acid methyl ester

Methyl 5-bromo-thiophene-2-carboxylate is one of the organic compounds. It has unique physical properties, let me tell you in detail.
Looking at its appearance, under room temperature and pressure, it is mostly in the state of white to light yellow crystalline powder. This shape is easy to observe and use. Among many chemical operations, this shape is conducive to precise measurement and reaction operations.
The melting point is about 39-43 ° C. The melting point is an important physical property of the substance, from which the purity geometry of the compound can be determined. If the purity is high, the melting point range is narrow and approaches the theoretical value; if it contains impurities, the melting point will be reduced and the range will be wider. This property is of great significance for the purification and quality control of compounds.
The boiling point is roughly 240-242 ° C. The boiling point is closely related to the intermolecular force of the substance. The boiling point value of methyl 5-bromo-thiophene-2-carboxylate reflects the strength of the intermolecular force. This is a key consideration when separating, purifying and setting the reaction conditions.
Solubility is also an important physical property. The substance is slightly soluble in water, but soluble in common organic solvents such as ethanol, ether, dichloromethane, etc. This solubility characteristic provides a basis for the selection of suitable reaction solvents in organic synthesis reactions. The solvent that can dissolve the reactants and is conducive to the reaction can be selected according to the reaction requirements, so that the reaction can be carried out efficiently and smoothly.
In addition, the density of methyl 5-bromo-thiophene-2-carboxylate is about 1.62g/cm ³. Density, as an inherent property of substances, plays an important role in material calculation and equipment design in chemical production and experimental operations. Knowing the density can accurately calculate the dosage and volume of substances to ensure the accuracy of production and experiments. These physical properties together constitute the characteristics of methyl 5-bromo-thiophene-2-carboxylate, which lays a solid foundation for its application in many fields such as organic synthesis and medicinal chemistry.

5-Bromo-thiophene-2-carboxylic acid methyl ester, this is an organic compound. Its chemical properties are unique and valuable for investigation.
From the perspective of the properties of halogenated hydrocarbons, this compound can participate in nucleophilic substitution reactions due to the presence of bromine atoms. Bromine atoms are highly active and can be replaced by nucleophilic reagents such as hydroxyl and amino groups under suitable conditions, thereby deriving new compounds with more complex structures. For example, when co-heated with sodium hydroxide aqueous solution, bromine atoms can be replaced by hydroxyl groups to generate corresponding alcohol derivatives; when reacted with ammonia or amine compounds, nitrogen-containing derivatives can be obtained. This is often used in organic synthesis to construct nitrogen-containing heterocyclic structures, laying the foundation for the creation of new drugs or functional materials.
In terms of the characteristics of ester groups, methyl 5-bromo-thiophene-2-carboxylic acid esters can undergo hydrolysis. Under acidic conditions, hydrolysis generates 5-bromo-thiophene-2-carboxylic acid and methanol; in alkaline environments, hydrolysis is more thorough, resulting in carboxylic salts and methanol. This reaction is often used in organic synthesis to prepare carboxylic acid compounds. In addition, ester groups can also participate in alcoholysis and aminolysis reactions. Reaction with different alcohols can give new ester compounds, and reaction with ammonia or amines produces amides, providing an effective way for structural modification and functional expansion of organic compounds.
Furthermore, the thiophene ring endows the compound with certain aromatic and electronic properties. The conjugated system of the thiophene ring gives the compound a unique electron cloud distribution, which affects its chemical activity and physical properties. For example, the distribution of electron cloud density on the thiophene ring causes it to have specific regioselectivity in the electrophilic substitution reaction. When reacting with electrophilic reagents such as bromine, substituents can be introduced at specific positions in the thiophene ring, providing the possibility for the synthesis of thiophene derivatives with specific functions.
In summary, methyl 5-bromo-thiophene-2-carboxylate has rich and diverse chemical properties, and has broad application prospects in many fields such as organic synthesis, medicinal chemistry, and materials science, providing a broad space for researchers to carry out innovative research.

The common synthesis method of methyl 5-bromo-thiophene-2-carboxylate is achieved through a multi-step reaction. The first step is often to use thiophene as the starting material. Thiophene is aromatic and has a specific electron cloud distribution, which can be used to carry out the reaction.
React thiophene with bromine under appropriate conditions, such as at low temperature and in the presence of a suitable catalyst, such as iron powder or iron tribromide. Bromine electrophilic attacks the thiophene ring. After electrophilic substitution, bromine atoms are introduced at the 5-position of thiophene to obtain 5-bromothiophene. This step requires careful control of the reaction temperature and bromine dosage to prevent the formation of polybrominated by-products.
Next step, 5-bromothiophene reacts with carbon dioxide under specific conditions, such as making Grignard reagent with metal magnesium first. 5-bromothiophene reacts with magnesium in anhydrous ether and other solvents to form 5-bromothiophene magnesium halide. This Grignard reagent has high activity and can react with carbon dioxide. Carbon dioxide is used as an electrophilic reagent. After nucleophilic addition, a carboxyl group is introduced at the 2-position of the thiophene ring to generate 5-bromo-thiophene-2-carboxylic acid.
Last step, the esterification reaction of 5-bromo-thiophene-2-carboxylic acid with methanol under acid catalysis occurs. Sulfuric acid or p-toluenesulfonic acid is often used as a catalyst. Under heating conditions, the carboxylic group of the carboxylic acid dehydrates and condensates with the hydroxyl group of methanol to form methyl 5-bromo-thiophene-2-carboxylate. During the reaction process, the generated water can be removed by a water separator, which prompts the reaction equilibrium to move in the direction of forming esters to increase the yield. In this way, through this series of reactions, the target product 5-bromo-thiophene-2-carboxylic acid methyl ester can be obtained.

Methyl 5-bromo-thiophene-2-carboxylate is widely used and has important applications in many fields.
In the field of medicinal chemistry, it is a key intermediate in organic synthesis. It can go through a series of chemical reactions to construct complex drug molecular structures. For example, synthesizing heterocyclic compounds with specific biological activities, modified and modified, may become new drugs for the treatment of specific diseases. Due to the unique chemical properties of thiophene rings with bromine atoms and ester groups, it can participate in a variety of nucleophilic substitution and coupling reactions, providing a variety of structural modification possibilities for drug research and development, and helping to create high-efficiency and low-toxicity new drugs.
In the field of materials science, methyl 5-bromo-thiophene-2-carboxylate is also used. It can be used as a raw material for the preparation of functional materials and participates in polymer synthesis. The thiophene structure endows the polymer with special electrical and optical properties, such as the preparation of conductive polymers, optoelectronic materials, etc. It may have potential applications in organic Light Emitting Diode (OLED), solar cells and other fields, which can optimize material properties, improve device efficiency and stability.
In pesticide chemistry, it can be used to synthesize new pesticides. Bromine atoms and thiophene ring structures help to enhance the biological activity and selectivity of compounds against specific pests or bacteria. After rational design and synthesis, high-efficiency, low-residue and environmentally friendly pesticide products may be developed, providing new options for agricultural pest control.

5-Bromo-thiophene-2-carboxylic acid methyl ester, the price of this product varies with various conditions in the market. Looking at the market conditions of the past, the abundance of materials, the amount of demand, and the difficulty of making methods are all variables in price.
If the materials are abundant, easy to harvest, and the buyer is not in abundance, the price may be flat. If the time is abundant, the raw materials are widely available, the workshop is smooth, the market is abundant, and the buyer is not in a hurry, the price will often be low.
On the contrary, if the raw materials are rare, the production is complicated, or there are many people who need them, the price will rise. I still remember that at a certain time, the origin of raw materials suffered a disaster, the source was scarce, and the improvement of the manufacturing method was unfinished, resulting in a thin output. And the use of various industries was so urgent that the demand exceeded the supply, and the price rose sharply.
And the distance of the city, the presence or absence of competing products, are also related to the price. The nearby city, the freight province, the price or affordable; the distant city, plus the cost of transshipment, the price will increase. If competing products come out one after another, and there are many contenders, in order to seize the market, the price may also drop.
And today's changes in politics and technology can also move its price. The support of politics and the creation of new technologies can make the market conditions different, and the price will also vary accordingly. Therefore, if you want to know the market price of methyl 5-bromo-thiophene-2-carboxylate, you can't look at one end alone.