5-Bromo-N-tert-butyl-2-thiophenesulfonamide

5-Bromo-N-tert-butyl-2-thiophenesulfonamide, this is an organic compound. Its chemical properties are unique and worth exploring.
Looking at its structure, the bromine atom at position 5 has high reactivity and can initiate many nucleophilic substitution reactions. Due to its electronegativity and volume, the bromine atom can affect the electron cloud distribution and spatial structure of the molecule, making it vulnerable to attack by nucleophiles or the typical reaction of halogenated hydrocarbons. For example, it reacts with nucleophiles such as alcohols and amines under suitable conditions to generate new derivatives, providing diverse paths for organic synthesis.
N-tert-butyl moiety, due to the large steric resistance of tert-butyl, has a profound impact on the stability and reaction selectivity of molecules. Its large structure can prevent the reaction reagent from approaching the nitrogen atom. In some reactions, it can change the reaction process and product distribution, or enhance the resistance of the molecule to specific chemical reactions, making the molecule more stable under specific conditions.
2-thiophene sulfonamide thiophene ring, as an aromatic heterocycle, has aromatic properties, endowing the molecule with a unique electron conjugation system. This conjugated system affects the electronic fluidity and reactivity of molecules, and can undergo electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. The reaction check point is restricted by the localization effect of the substituents on the ring. Sulfonamide groups are also reactive and can participate in a variety of organic reactions, such as hydrolysis with acids and bases, or the formation of complexes with metal ions.
5-Bromo-N-tert-butyl-2-thiophenesulfonamides are rich in chemical properties. In the fields of organic synthesis, pharmaceutical chemistry, etc., due to the synergistic effect of each part of the structure, it shows broad application prospects, laying the foundation for the synthesis of new functional materials and drugs.

There are several methods for preparing 5-bromo-N-tert-butyl-2-thiophenesulfonamide.
First, 2-thiophenesulfonyl chloride is used as the starting material. First, 2-thiophenesulfonyl chloride is reacted with tert-butylamine in a suitable solvent, such as dichloromethane, toluene, etc., at a mild temperature, usually between 0 ° C and room temperature. This reaction requires the presence of acid binding agents, such as triethylamine, pyridine, etc., to absorb the hydrogen chloride generated by the reaction. After the reaction is completed, the precursor of 5-bromo-N-tert-butyl-2-thiophenesulfonamide can be obtained by regular post-treatment, such as washing with water, drying with organic phase, and concentrating. Then a bromination reaction is carried out with a brominating agent, such as N-bromosuccinimide (NBS), in the presence of an initiator such as benzoyl peroxide, in an inert solvent such as carbon tetrachloride, heated to a reflux temperature, and the target product is separated and purified.
Second, 5-bromo-2-thiophenesulfonyl chloride is used as the starting material. It is directly reacted with tert-butylamine under the above-mentioned similar reaction conditions, in a suitable solvent, in the presence of acid binding agent. In this process, the sulfonyl chloride group of 5-bromo-2-thiophene sulfonyl chloride undergoes nucleophilic substitution reaction with the amino group of tert-butylamine to generate 5-bromo-N-tert-butyl-2-thiophene sulfonamide. After the reaction is completed, it is isolated and purified by extraction, washing, drying, column chromatography, etc., to obtain high-purity products.
Third, 2-thiophene sulfonic acid is used as the starting material. It is first converted into the corresponding sulfonate, such as methyl or ethyl esters, which can be prepared by reacting with methanol or ethanol under the catalysis of concentrated sulfuric acid. The 5-position of the thiophene ring is then brominated with a brominating agent, after which the sulfonate is hydrolyzed to sulfonic acid and then converted to sulfonyl chloride. Finally, it is reacted with tert-butylamine under the conditions described above, and through a series of post-treatment steps, 5-bromo-N-tert-butyl-2-thiophenesulfonamide is obtained.

5-Bromo-N-tert-butyl-2-thiophenesulfonamide, an organic compound, is useful in various fields.
In the field of medicinal chemistry, it is often a key intermediate for the synthesis of drugs. Because thiophene and sulfonamide structures are widely found in many biologically active molecules. With this compound, chemists can modify its structure and introduce different functional groups to synthesize new compounds with specific pharmacological activities, such as developing drugs with antibacterial, anti-inflammatory or anti-tumor activities. For example, in some innovative drug development processes targeting specific disease targets, 5-bromo-N-tert-butyl-2-thiophene sulfonamide may be used as a starting material to construct molecular structures with high affinity to disease-related protein targets through multi-step reactions, and then it is expected to become new drugs for treating corresponding diseases.
In the field of materials science, this compound may contribute to the preparation of special functional materials. The thiophene structure gives it certain electronic properties, and the sulfonamide group can participate in a variety of chemical reactions. Based on this, polymer materials with special electrical and optical properties may be synthesized. For example, in the synthesis of organic semiconductor materials, it can be introduced into the polymer chain as a structural unit, or the charge transport performance of the material can be regulated, which contributes to the development of organic electronic devices, such as organic field effect transistors and organic Light Emitting Diodes.
In the field of agricultural chemistry, it also has potential application value. Due to its special chemical structure, it may be able to derive compounds with insecticidal, bactericidal or herbicidal activities. After rational structural modification and activity screening, new pesticides may be developed to help agricultural pest control and weed control. Compared with traditional pesticides, they may have higher activity, lower environmental toxicity and better biodegradability, which is in line with the current needs of green agriculture development.

I look at what you are asking about "5 - Bromo - N - tert - butyl - 2 - thiophenesulfonamide", which is a chemical substance. Its market price often varies due to many factors, making it difficult to generalize.
First, the complexity of the production process is related to the price. If the preparation process of this substance is cumbersome, requires multiple fine processes, consumes a lot of raw materials and energy, the cost will rise, and the price will also rise. For example, if the synthesis process requires a special catalyst, and the catalyst is not easy to prepare and expensive, the cost of the product will increase significantly, and the market price will also be high.
Second, the market supply and demand situation determines the price. If the market demand for this substance is strong, but the supply is limited, if only a few manufacturers can produce it, and the output is not high, the price will often rise. On the contrary, if the demand is low, the manufacturer may reduce the price for promotion.
Third, the purity has a great impact on the price. High purity "5 - Bromo - N - tert - butyl - 2 - thiophenesulfonamide" is often used in high-end scientific research or special industrial fields, and the preparation is difficult, so the price is much higher than that of ordinary purity products.
Fourth, manufacturers and sales channels also affect the price. Different manufacturers have different pricing due to different production costs and brand positioning. Furthermore, direct sales and sales through multi-level distributors, the price will be different, multi-level distribution or make the price layer up the ante.
In short, to know the exact market price of "5 - Bromo - N - tert - butyl - 2 - thiophenesulfonamide", you need to consider the above factors comprehensively, and it is advisable to consult chemical product suppliers, distributors, or refer to professional chemical product price information platforms to obtain more accurate price information.

5-Bromo-N-tert-butyl-2-thiophenesulfonamide is also a chemical substance. In terms of its safety, many aspects need to be paid attention to.
This substance has a latent risk in toxicology. Its effect on the human body is different in contact routes and effects. If it is exposed to the skin or causes skin irritation, it can be seen that it is red, swollen and itchy. When using it, avoid direct contact with the skin. It is advisable to wear protective clothing and gloves. If it is inadvertently touched, rinse with plenty of water quickly.
If inhaled through the respiratory tract, or irritates the respiratory tract, causing coughing and asthma, it is very important to operate with good ventilation. If necessary, respiratory protective equipment should be prepared. If inhaled inadvertently, leave the scene immediately and go to a place with fresh air.
Furthermore, ingesting this substance by mistake may damage the digestive system, causing nausea, vomiting, abdominal pain and other diseases. Therefore, it is strictly forbidden to eat or smoke in the operating room. If ingested by mistake, seek medical treatment as soon as possible.
In terms of the environment, it may have an impact on the ecology. If it flows into the water body, or endangers aquatic organisms. When using, waste must be disposed of in accordance with relevant environmental regulations, and do not dump it at will to avoid polluting the environment.
In short, when handling 5-bromo-N-tert-butyl-2-thiophenesulfonamide, it is necessary to clarify its safety, abide by the operating procedures, and pay attention to personal protection and environmental protection, so that the security is safe.