5-Bromo-2-thiophenesulfonamide

5-Bromo-2-thiophene sulfonamide, this is an organic compound. It has many unique chemical properties.
Looking at its structure, the bromine atom is connected to the thiophene ring and the sulfonamide group, which endows it with various reactivity. In terms of physical properties, the compound is usually solid and may have some solubility in specific organic solvents.
When it comes to chemical activity, the bromine atom is extremely active and can participate in nucleophilic substitution reactions. In case of nucleophilic reagents, the bromine atom is easily replaced to form new organic compounds, which is an important reaction path for the construction of complex organic molecules. The thiophene ring also has unique electronic properties, and its π electron cloud distribution makes the ring have certain aromatic properties, which can participate in aromatic electrophilic substitution reactions, such as halogenation, nitration, sulfonation, etc. The
sulfonamide group is also a key functional group, which is weakly acidic and can react with bases to form corresponding salts. At the same time, the nitrogen atom in the sulfonamide group can act as a hydrogen bond donor or receptor, participating in intermolecular hydrogen bonding, which affects the physical properties of compounds, such as melting point, boiling point and solubility. In the field of organic synthesis, 5-bromo-2-thiophenesulfonamide is often used as a key intermediate. Through different chemical reactions, various compounds with biological activity or special functions can be prepared, which has important application prospects in the fields of medicinal chemistry and materials science.

5-Bromo-2-thiophene sulfonamide is a class of organic compounds. Its uses are quite extensive and are described as follows:
In the field of medicinal chemistry, this compound is often a key intermediate for the creation of new drugs. Taking antibacterial drugs as an example, their structural properties can help chemists modify molecules, and then develop agents with high inhibitory activity against specific pathogens. Due to the existence of thiophene rings and sulfonamide groups, it gives it unique biological activity and pharmacokinetic properties, or can enhance the ability of drugs to interfere with bacterial cell walls or protein synthesis processes, achieving antibacterial purposes.
In the field of materials science, 5-bromo-2-thiophenesulfonamide also has important uses. In the preparation of conductive polymer materials, it can be introduced into the polymer structure by specific chemical reactions. In this way, not only can the electron cloud distribution of the material be adjusted, but also its electrical properties can be changed, such as increasing electrical conductivity; and the introduction of bromine atoms can improve the thermal stability and flame retardancy of the material, so that the resulting material can be used in electronic devices, aerospace and other fields that require strict material properties.
Furthermore, in organic synthesis chemistry, it is an important cornerstone for the construction of more complex organic molecules. Due to the good reactivity of bromine atoms and sulfonamide groups, they can participate in various organic reactions such as nucleophilic substitution and coupling. Chemists can use this to construct carbon-carbon bonds or carbon-heteroatom bonds to synthesize organic compounds with special structures and functions. For example, in the total synthesis of natural products, reactants are a key step to help achieve the precise construction of target molecules.

The synthesis of 5-bromo-2-thiophene sulfonamide is an important topic in organic synthetic chemistry. The synthesis of this compound can follow the following methods.
One of the methods can be started from thiophene. First, thiophene is sulfonated, and a specific sulfonation reagent, such as a mixture of concentrated sulfuric acid and sulfur trioxide, is introduced into the 2-position of thiophene at a suitable temperature and reaction time to obtain 2-thiophene sulfonic acid. Subsequently, 2-thiophene sulfonic acid is converted into its acid chloride form, which is often reacted with reagents such as sulfoxide chloride or phosphorus pentachloride to obtain 2-thiophene sulfonyl chloride. Finally, 2-thiophene sulfonyl chloride and brominating reagents, such as the combination of sodium bromide and sulfuric acid, or directly with liquid bromine, under the action of catalyst, bromine atoms are introduced at the 5-position of the thiophene ring, and then reacted with ammonia or amine compounds to obtain 5-bromo-2-thiophene sulfonamide.
Second, 5-bromothiophene can also be used as a starting material. The sulfonation reaction of 5-bromothiophene is first carried out, and the appropriate sulfonation conditions are selected to introduce the sulfonyl group into the 2-position. The subsequent steps are similar to the above-mentioned reaction from 2-thiophene sulfonic acid, that is, the sulfonyl chloride is first prepared, and then reacted with ammonia or amine to form the target product. During the
synthesis process, the conditions of each step of the reaction need to be carefully regulated. Factors such as temperature, reaction time, and reagent dosage all have a significant impact on the reaction yield and selectivity. For example, the sulfonation reaction temperature is too high, or excessive sulfonation is caused; the improper dosage of brominating reagents during the halogenation reaction will also affect the selectivity of the introduction position of bromine atoms. In addition, the choice of the reaction solvent is also very critical. According to the characteristics of each step, a suitable polar or non-polar solvent should be selected to promote the reaction. In this way, the effective synthesis of 5-bromo-2-thiophenesulfonamide can be achieved through careful operation of various steps.

The price of all kinds of things in the market often varies with time, place and quality. As for 5-bromo-2-thiophenesulfonamide, its price is difficult to determine in the market.
In the past, the price of this chemical product fluctuated due to the difficulty of preparation and the amount of demand. If the preparation method is simple and the demand in the market is not strong, the price may be slightly cheaper. However, if the preparation requires exquisite techniques, the raw materials used are rare and rare, and there are many people who want it, the price will be high.
Furthermore, the region of the city is also an important factor. In the prosperous city of Dayi, the chemical industry is prosperous, raw materials are easy to obtain, transactions are frequent, or because of competition, the price may tend to be flat. And in remote places, transportation is difficult, and it is not easy to get things, so the price should be increased by its freight and other expenses, which must be higher than that of Tongyi.
Also, the quality is also related to the price. Those who are refined and flawless must have a higher price than those who contain impurities. It is difficult to determine the price of 5-bromo-2-thiophenesulfonamide in the market today. If you want to know the details, you must consult the chemical merchants and the places of the market, or you can approach the true price. And the market conditions change like the wind and clouds, and today's price may be different tomorrow, so you can know the general idea by checking the market often.

5-Bromo-2-thiophene sulfonamide is also an organic compound. Its preparation requires specific chemical processes and expertise. If you want to know the geometry of the manufacturer today, let me come to you.
In Huaxia, many chemical companies are involved in the production of such compounds. For example, [X] Chemical Co., Ltd., which focuses on the manufacture of fine chemicals, has considerable experience in the production of organosulfonamide compounds, and 5-bromo-2-thiophene sulfonamide is also one of its products. The company adheres to the concept of excellence, pays attention to the optimization of production processes, and strives for high product quality.
Another example is [Y] Chemical Technology Company, which is driven by scientific and technological innovation and is committed to the research and development and production of new organic compounds. In the production of 5-bromo-2-thiophenesulfonamide, it introduces advanced equipment and technology, strictly controls the quality checkpoint, and the products are widely sold in domestic and foreign markets.
In addition, [Z] Fine Chemical Enterprise has been deeply involved in the field of organic synthesis for many years, and 5-bromo-2-thiophenesulfonamide is also its key product. With its profound technical accumulation and rich practical experience, the quality of the products produced by the company is stable and has been praised by the industry.
In chemical production, safety is the first priority, and environmental protection is the most important. All factories need to follow relevant regulations and take proper environmental protection measures to ensure the safety of the production process and the friendliness of the environment. Although there are many such manufacturers, if they want the best products, they need to carefully check their qualifications, reputation and product quality.